Biomedical Projects by Theme

Biomedical Projects by Theme

Cancer in Biomedicine

Groups / Projects Research Lead Dept / Centre
Adaptive remodelling of metabolism during liver regeneration Project Leader Dr Andrew Cox
Analysing genetic roles of RNA-binding proteins and alternative splicing in Drosophila stem cells Project Leader Professor Gary Hime
Barrow laboratory: Tissue immunosurveillance strategies Head of Laboratory Dr Alexander David Barrow
Brown laboratory: Cancer metabolism Head of Laboratory Dr Kristin Brown
Cancer in Biomedicine
Cheng laboratory: Stem cell and organ size control regulation Head of Laboratory Associate Professor Louise Cheng
Clinical Proteomics Project Leader Dr Jonathon Mangum
Coding the future: next-gen bioinformatic tools for nanopore data Project Leader Dr Mike Clark
Cox laboratory: Metabolic Regulation of Growth Head of Laboratory Dr Andrew Cox
Defining new roles for the Hippo signalling pathway in skeletal muscle Research Project Leader Associate Professor Paul Gregorevic
Developing innovative animal and cell culture models to study and treat muscular dystrophies Research Project Leader Associate Professor Paul Gregorevic
Development of effector regulatory T cells Project Leader Professor Axel Kallies
Towards understanding new therapies for obesity and diabetes: discovering new regulators of lipid metabolism Research Project Leader Professor Matthew Watt
Dolcetti Laboratory: Clinical and Translational Immunotherapy Head of Laboratory Professor Riccardo Dolcetti
Eckersley-Maslin laboratory: Stem cell and cancer epigenetics Head of Laboratory Dr Melanie Eckersley-Maslin
EMT regulators in intestinal and germline stem cells Project Leader Professor Gary Hime
Exploring new roles for the TGFβ signalling network as a key regulator of skeletal muscle in health and disease Research Project Leader Associate Professor Paul Gregorevic
Genetics of blood brain barrier formation Project Leader Professor Ben Hogan
Gregorevic laboratory: Muscle Research and Therapeutics Head of Laboratory Professor Paul Gregorevic
Hime laboratory: Stem cell genetics and Drosophila models of human disease Head of Laboratory Professor Gary Hime
Hogan laboratory: Vascular Cell and Developmental Biology Head of Laboratory Professor Ben Hogan
How do dietary nutrients affect the ability of stem cells and stem cell-derived tumours to grow and divide? Project Leader A/Professor Louise Cheng
How do neural stem cells maintain quiescence? Project Leader A/Professor Louise Cheng
How do neurons maintain their specialised status? Project Leader A/Professor Louise Cheng
How do tumours compete for resources to grow? Project Leader A/Professor Louise Cheng
Immunosurveillance pathways in brain cancer Project Leader Dr Alexander David Barrow
Investigating the Dystrophin-Glycoprotein Complex to Protect Muscles from Wasting Conditions Research Project Leader Professor Gordon Lynch
Investigating the role of cachexia in the response to surgical tumour resection in mice Research Project Leader Professor Gordon Lynch
Kallies laboratory: Molecular immunology Head of Laboratory Professor Axel Kallies
Koay Laboratory: Unconventional T cells in Immunity and Disease Head of Laboratory Dr Hui-Fern Koay
Learning from skeletal muscles to develop new treatments for cancer Research Project Leader Associate Professor Paul Gregorevic
Live imaging of cellular signalling in vascular development and disease models Project Leader Professor Ben Hogan
Lynch laboratory: Basic and clinical myology Head of Laboratory Professor Gordon Lynch
Mackay laboratory: Tissue-resident memory T cells; lymphocyte differentiation; peripheral immunity Lab Head, NHMRC Leadership Fellow, Dame Kate Campbell Fellow Professor Laura Mackay FAHMS
Mantamadiotis laboratory: Brain Cancer Molecular Biology Dr Theo Mantamadiotis
Menden laboratory: Computational biomedicine Head of Laboratory Michael P. Menden
Metabolic reprogramming of skeletal muscle stem cells Research Project Leader Professor Gordon Lynch
Molecular basis for growth factor surveillance in natural killer cells Project Leader Dr Alexander David Barrow
Molecular basis for growth factor surveillance in plasmacytoid dendritic cells Project Leader Dr Alexander David Barrow
Molecular mechanisms controlling lymphangiogenesis Project Leader Professor Ben Hogan
Molecular mechanisms of drug resistance in cancer Project Leader Dr Jonathon Mangum
Mueller laboratory: Visualising the immune system in action Head of Laboratory Professor Scott Mueller
Novel regulators of germline stem cells Project Leader Professor Gary HIme
Parker laboratory: Structural biology and computational Design Head of Laboratory and Director, Bio21 Institute Professor Michael Parker
Precursor exhausted T cells in chronic infection and tumors Project Leader Professor Axel Kallies
Project 1. Development of improved cancer vaccines to enhance the efficacy of immunotherapy combination strategies Project Leader Professor Riccardo Dolcetti
Project 2. Identification and characterisation of novel classes of therapeutically relevant tumour neo-antigens Project Leader Professor Riccardo Dolcetti
Resident memory T cells (Trm) Project Leader Professor Axel Kallies
Rouiller laboratory: Molecular nanomachines and mechanisms of disease Associate Professor Isabelle Rouiller
Sex-specific regulation of adipose tissue immune cells Project Leader Professor Axel Kallies
Shakeel laboratory: Structural genome regulation Lab Head & Principal Research Fellow A/Prof Shabih Shakeel
The Bonn and Melbourne Research and Graduate School Melbourne Coordinator Dr Marie Greyer
Therapeutic potential of skeletal muscle plasticity and slow muscle programming for muscular dystrophy Research Project Leader Professor Gordon Lynch
Transcriptional regulation of intestinal organoid differentiation Project Leader Professor Gary Hime
Transcriptional reprogramming of metabolism in liver cancer Project Leader Dr Andrew Cox
Unravelling the mysteries of E3 ubiquitin ligase in regulating skeletal muscle size and function Research Project Leader Associate Professor Paul Gregorevic
Villadangos laboratory: Immunology and cell biology Head of Laboratory Professor Jose Villadangos
Watt laboratory: Metabolism and Diabetes Head of Laboratory Professor Matthew Watt

58

Cardio-Respiratory

Groups / Projects Research Lead Dept / Centre
Allen laboratory: Central cardiovascular regulation Head of Laboratory Professor Andrew Allen
Brain networks processing respiratory sensations Project Leader Professor Stuart Mazzone
Delbridge & Weeks laboratory: Cardiac Phenomics & Signalling Head of Laboratory Professor Lea Delbridge
Co-Lead of Laboratory Dr Kate Weeks
Diabetic cardiomyopathy – an epidemic disease Research Project Leader Professor Lea Delbridge
Dr Kate Weeks
Effects of hypertension on renal and hindquarter vascular reactivity in vivo and in vitro Project Leader Associate Professor Christine Wright
Endothelin pharmacology in the setting of pulmonary hypertension Project Leader Professor James Angus
Functional neuroanatomy of genitourinary vasculature Project Leaders Professor Janet Keast / Dr Peregrine Osborne
Human brain networks processing respiratory sensations Project Leader Professor Stuart Mazzone
Keast-Osborne Laboratory: Neural and Bioelectronic Control of Pelvic Organs Joint Head of Lab Prof Janet Keast
Joint Head of Lab A/Prof Peregrine Osborne
Lung Disease Research Laboratory Head of Laboratory Professor Gary P Anderson
Mazzone laboratory: Respiratory Sensory Neuroscience Head of Research Group Professor Stuart Mazzone
Mechanisms of diastolic heart failure Research Project Leader Professor Lea Delbridge
Dr Kate Weeks
Montgomery laboratory: Metabolic Tissue Cross-Talk Head of Laboratory Dr Magdalene Montgomery
Novel technique to determine the pKA of clonidine at prejunctional α2-adrenoceptors in sympathetic transmission Project Leader Professor James Angus
Pathogenesis of chronic lung disease Head of Laboratory Dr Michelle Hansen
Preclinical pharmacology – cardiovascular efficacy and safety R&D Project Leader Associate Professor Christine Wright
Reassessment of α1-adrenoceptor mechanism in artery contraction: role of ATP and pannexin channels Project Leader Professor James Angus
Schneider-Futschik laboratory: Rare and complex lung disease Head of Laboratory A/Prof Elena Schneider-Futschik
Lung Health Research Centre
Sex, adiposity and cardiac vulnerability Research Project Leader Professor Lea Delbridge
Dr Kate Weeks
Smith laboratory: Cardiac Genetics Head of Laboratory Associate Professor Kelly Smith
The cardiovascular pharmacology of snake venoms from Papua New Guinea and Australia Project Leader Associate Professor Christine Wright
The link between cardiovascular disease and neurodegeneration – focus on Alzheimer’s disease Project Leader Associate Professor Christine Wright
Transcriptional profiling of sensory neurons Project Leader Professor Stuart Mazzone
Trovafloxacin – an antibiotic with additional properties Project Leader Professor James Angus
Yao laboratory: Cardiovascular Neuroscience Head of Laboratory Dr Song Yao

25

Cell Signalling

Groups / Projects Research Lead Dept / Centre
Analysing genetic roles of RNA-binding proteins and alternative splicing in Drosophila stem cells Project Leader Professor Gary Hime
Bedoui laboratory: Innate and adaptive interactions in immunity to infection Head of Laboratory Professor Sammy Bedoui
Brown laboratory: Cancer metabolism Head of Laboratory Dr Kristin Brown
Building a urogenital nervous system connectome Project Leaders Professor Janet Keast / Dr Peregrine Osborne
Cell Signalling
Cellular trafficking and male fertility Project Leader Professor Gary Hime
Crack laboratory: Neuropharmacology Head of Laboratory Professor Peter Crack
Defining new roles for the Hippo signalling pathway in skeletal muscle Research Project Leader Associate Professor Paul Gregorevic
Delbridge & Weeks laboratory: Cardiac Phenomics & Signalling Head of Laboratory Professor Lea Delbridge
Co-Lead of Laboratory Dr Kate Weeks
Developing a novel class of therapeutics for muscle wasting and frailty Research Project Leader Dr Benjamin Parker
Developing innovative animal and cell culture models to study and treat muscular dystrophies Research Project Leader Associate Professor Paul Gregorevic
Diabetic cardiomyopathy – an epidemic disease Research Project Leader Professor Lea Delbridge
Dr Kate Weeks
Discovering and characterizing new genes involved in innate immunity, tissue injury and fibrosis Project Leader Professor Christine Wells
Towards understanding new therapies for obesity and diabetes: discovering new regulators of lipid metabolism Research Project Leader Professor Matthew Watt
Exercise-induced liver-muscle cross-talk and mitochondrial adaptations Research Project Leader Dr Magdalene Montgomery
Exploring new roles for the TGFβ signalling network as a key regulator of skeletal muscle in health and disease Research Project Leader Associate Professor Paul Gregorevic
Functional neuroanatomy of genitourinary vasculature Project Leaders Professor Janet Keast / Dr Peregrine Osborne
Genetics of blood brain barrier formation Project Leader Professor Ben Hogan
Gleeson laboratory: Membrane trafficking in the secretory and endocytic pathways in health and disease. Head of Laboratory Professor Paul Gleeson
Gregorevic laboratory: Muscle Research and Therapeutics Head of Laboratory Professor Paul Gregorevic
Gunnersen laboratory: Neuron development and plasticity Head of Laboratory Associate Professor Jenny Gunnersen
Hogan laboratory: Vascular Cell and Developmental Biology Head of Laboratory Professor Ben Hogan
Learning from skeletal muscles to develop new treatments for cancer Research Project Leader Associate Professor Paul Gregorevic
Live imaging of cellular signalling in vascular development and disease models Project Leader Professor Ben Hogan
Mantamadiotis laboratory: Brain Cancer Molecular Biology Dr Theo Mantamadiotis
Mechanisms of diastolic heart failure Research Project Leader Professor Lea Delbridge
Dr Kate Weeks
Molecular mechanisms controlling lymphangiogenesis Project Leader Professor Ben Hogan
Montgomery laboratory: Metabolic Tissue Cross-Talk Head of Laboratory Dr Magdalene Montgomery
Murray laboratory: Myelin biology Head of Laboratory Associate Professor Simon Murray
Novel regulators of germline stem cells Project Leader Professor Gary HIme
Parker laboratory: Metabolic Proteomics & Signal Transduction Head of Laboratory A/Prof Benjamin Parker
Parker laboratory: Structural biology and computational Design Head of Laboratory and Director, Bio21 Institute Professor Michael Parker
Sex, adiposity and cardiac vulnerability Research Project Leader Professor Lea Delbridge
Dr Kate Weeks
Skeletal muscle signal transduction related to exercise, metabolic disease and human health Research Project Leader Dr Benjamin Parker
Smith laboratory: Cardiac Genetics Head of Laboratory Associate Professor Kelly Smith
Systems genetics of muscle metabolism Research Project Leader Dr Benjamin Parker
The Bonn and Melbourne Research and Graduate School Melbourne Coordinator Dr Marie Greyer
The heart as a central player in tissue cross-talk Research Project Leader Dr Magdalene Montgomery
The role of protein modifications on muscle development Research Project Leader Dr Benjamin Parker
Tissue communication in non-alcoholic fatty liver disease (NALFD) and liver fibrosis Research Project Leader Dr Magdalene Montgomery
Transcriptional regulation of intestinal organoid differentiation Project Leader Professor Gary Hime
Uncovering the interplay between innate immunity and the blood brain barrier in disorders of the CNS Project Leader Professor Christine Wells
Understanding metabolic cross-talk in health and disease - Focus on type 2 diabetes and fatty liver Research Project Leader Dr Magdalene Montgomery
Understanding the interaction between microbiota and T cell immunity Project Leader Professor Sammy Bedoui
Unravelling the mysteries of E3 ubiquitin ligase in regulating skeletal muscle size and function Research Project Leader Associate Professor Paul Gregorevic
Watt laboratory: Metabolism and Diabetes Head of Laboratory Professor Matthew Watt

46

Cellular Imaging & Structural Biology

Groups / Projects Research Lead Dept / Centre
Adverse maternal environment in females born small and transgenerational consequences Research Project Leader Professor Mary Wlodek
Bacterial secretion systems Project Leader Dr Debnath Ghosal
Being born small programs growth restriction, deficits and disease in the next generation Research Project Leader Professor Mary Wlodek
Cellular Imaging & Structural Biology
Dendritic cell maturation following different microbial stimulation Project Leader Professor William (Bill) Heath
Early life exercise reprograms pancreatic and heart deficits in offspring born small Research Project Leader Professor Mary Wlodek
Factors that accelerate photoreceptor death: The role of purines Head of Laboratory Professor Erica Fletcher
Fletcher laboratory: Visual neuroscience Head of Laboratory Professor Erica Fletcher
Ghosal laboratory: In situ structural biology Head of Laboratory Dr Debnath Ghosal
Gleeson laboratory: Membrane trafficking in the secretory and endocytic pathways in health and disease. Head of Laboratory Professor Paul Gleeson
Glial cells as a source of progenitor cells in degenerative disease Head of Laboratory Professor Erica Fletcher
Gooley laboratory: Receptor structural biology Head of Laboratory Professor Paul Gooley
Grinter laboratory: Protein structure, function, and AI design Head of Laboratory Dr Rhys Grinter
Gunnersen laboratory: Neuron development and plasticity Head of Laboratory Associate Professor Jenny Gunnersen
Harnessing local immunity to block the development of secondary bacterial pneumonia Project Leader Dr Linda Wakim
Hatters laboratory: Molecular mechanisms of neurodegeneration Head of Laboratory Professor Danny Hatters
Heath laboratory: CD8 T lymphocytes, dendritic cells, self tolerance and immunity Head of Laboratory Professor William (Bill) Heath
Imaging effector and memory T cell responses in the skin following Herpes Simplex Virus-1 infection Project Leader Professor William (Bill) Heath
Imaging the priming of CD8 Killer T cell responses to Herpes Simplex Virus-1 skin infection Project Leader Professor William (Bill) Heath
Improved vaccines by targeting to dendritic cells Project Leader Professor William (Bill) Heath
Intraepithelial T cells in anti-viral immunity Project Leader Professor Francis (Frank) Carbone
Intravital imaging of T cell responses in the brain during cerebral malaria infection Project Leader Professor William (Bill) Heath
Investigating the mechanism of action of the antiviral molecule, IFITM3 Project Leader Dr Linda Wakim
Keast-Osborne Laboratory: Neural and Bioelectronic Control of Pelvic Organs Joint Head of Lab Prof Janet Keast
Joint Head of Lab A/Prof Peregrine Osborne
Lymphoid stromal cells and control of immunity to infection and cancer Project Leader Professor Scott Mueller
Malaria and Tissue Resident Memory T cells (TRM) in the liver Project Leader Professor William (Bill) Heath
Mueller laboratory: Visualising the immune system in action Head of Laboratory Professor Scott Mueller
Murray laboratory: Myelin biology Head of Laboratory Associate Professor Simon Murray
Neural regulation of immunity Project Leader Professor Scott Mueller
Neuroanatomy of human visceral systems Professor Janet Keast
Priming of T cell responses to viral infection Project Leader Professor Scott Mueller
Rouiller laboratory: Molecular nanomachines and mechanisms of disease Associate Professor Isabelle Rouiller
Self-tolerance: Interactions between thymic stroma and dendritic cells Project Leader Professor William (Bill) Heath
Shakeel laboratory: Structural genome regulation Lab Head & Principal Research Fellow A/Prof Shabih Shakeel
Stojanovski laboratory: Mitochondrial biology and disease Head of Laboratory Professor Diana Stojanovski
Structure and function of bacterial "cytomotive" filaments Project Leader Dr Debnath Ghosal
T cell responses in the brain during experimental cerebral malaria infection Project Leader Professor Scott Mueller
The Bonn and Melbourne Research and Graduate School Melbourne Coordinator Dr Marie Greyer
The role of glia in inner retinal changes during retinal degeneration Head of Laboratory Professor Erica Fletcher
The role of glial cells in retinal vascular disease Head of Laboratory Professor Erica Fletcher
The role of microglia in age-related macular degeneration Head of Laboratory Professor Erica Fletcher
Tilley laboratory: Malaria parasite drug discovery Head of Laboratory, Redmond Barry Distinguished Professor of Biochemistry & Pharmacology, ARC Australian Laureate Fellow (2015-2020) Emeritus Professor Leann Tilley
Tissue-resident memory T cells Project Leader Professor Scott Mueller
Vaccination against liver-stage Plasmodium for malaria prevention Project Leader Professor William (Bill) Heath

44

Infection & Immunity

Groups / Projects Research Lead Dept / Centre
Coin Laboratory: Genomics and bioinformatics in infectious disease and cancer Head of Laboratory Professor Lachlan Coin
Corbett Laboratory: Mucosal-Associated Invariant T cell detection of microbial metabolites, activation and immune function Head of Laboratory A/Prof Alexandra Corbett
Day Laboratory: Malaria genomics, epidemiology and control Head of Laboratory Professor Karen Day
Genomic epidemiology and malaria surveillance Project Leader Professor Karen Day
Grinter laboratory: Protein structure, function, and AI design Head of Laboratory Dr Rhys Grinter
Haque Laboratory Head of Laboratory Associate Professor Ashraful Haque
How does ageing affect antibody responses? Project Leader Dr Amy Chung
Infection & Immunity
Investigating antimalarial drug resistance in response to community interventions in Ghana, West Africa Project Leader Professor Karen Day
Investigating the diversity of the variant antigen genes of Plasmodium falciparum Project Leader Professor Karen Day
Koay Laboratory: Unconventional T cells in Immunity and Disease Head of Laboratory Dr Hui-Fern Koay
Mackenzie laboratory: Intracellular virus replication and innate immunity Head of Laboratory Professor Jason Mackenzie
McConville laboratory: Microbial Metabolism Head of Laboratory Professor Malcolm McConville
Mintern laboratory: Vaccine and immunotherapy Head of Laboratory Prof Justine Mintern
Pidot Laboratory: Antibiotic Discovery and Biosynthesis Head of Laboratory Dr Sacha Pidot
Project 1. How do CD4+ T cells preserve memories during malaria? Head of Laboratory Associate Professor Ashraful Haque
Project 2. CD4+ T cells in acute Graft-versus-Host Disease Head of Laboratory Associate Professor Ashraful Haque
Project 3. Do malaria parasites sense and respond to the host during infection? Head of Laboratory Associate Professor Ashraful Haque
Scott Laboratory: Microbial glycoproteomics and host pathogen interactions Head of Laboratory Dr Nichollas Scott
Tilley laboratory: Malaria parasite drug discovery Head of Laboratory, Redmond Barry Distinguished Professor of Biochemistry & Pharmacology, ARC Australian Laureate Fellow (2015-2020) Emeritus Professor Leann Tilley
Villadangos laboratory: Immunology and cell biology Head of Laboratory Professor Jose Villadangos
Wheatley Laboratory Head of Laboratory Dr Adam Wheatley

22

Molecular Mechanisms of Disease

Groups / Projects Research Lead Dept / Centre
Understanding the plasticity of skeletal muscle in health and disease Research Project Leader Professor Gordon Lynch
"Clock-off time" for inflammation and remodelling in chronic inflammatory diseases: casein kinase inhibitors Primary Supervisor Professor Alastair Stewart
Adaptive remodelling of metabolism during liver regeneration Project Leader Dr Andrew Cox
Angiotensin and chemoreceptor function Research Project Leader Professor Andrew Allen
Antibody dependent cellular cytotoxicity - a neglected anti-HIV iImmune response! Project Leaders Professor Stephen Kent & Dr Amy Chung
Antimicrobial resistant bacterial pathogens Project Leader Professor Ben Howden
Application of genomics to public health and clinical microbiology Project Leader Professor Ben Howden
Autophagy and Norovirus replication Professor Jason Mackenzie
Bacterial secretion systems Project Leader Dr Debnath Ghosal
Bedoui laboratory: Innate and adaptive interactions in immunity to infection Head of Laboratory Professor Sammy Bedoui
Bornstein laboratory: Enteric neuroscience Head of Laboratory Professor Joel C Bornstein
Brain networks processing respiratory sensations Project Leader Professor Stuart Mazzone
Brooks laboratory: Innate immunity; anti-viral immunity Head of Laboratory Professor Andrew Brooks
Brown laboratory: Behavioural neuropharmacology Head of Laboratory Dr Robyn M Brown
Brown laboratory: Cancer metabolism Head of Laboratory Dr Kristin Brown
Building a urogenital nervous system connectome Project Leaders Professor Janet Keast / Dr Peregrine Osborne
Cell surface receptors for attachment and entry of influenza virus into cells of the innate immune system Project Leader Associate Professor Patrick Reading
Characterising the cellular roles of metals Research Project Leader Associate Professor Christopher McDevitt
Chronic immune activation during treated HIV disease Project Leader Professor Damian Purcell
Chung laboratory: Investigating the role of functional antibodies against Mycobacterium tuberculosis Head of Laboratory Dr Amy Chung
Clark laboratory: Transcriptomics and Neurogenetics Head of Laboratory Dr Mike Clark
Coding the future: next-gen bioinformatic tools for nanopore data Project Leader Dr Mike Clark
Coin Laboratory: Genomics and bioinformatics in infectious disease and cancer Head of Laboratory Professor Lachlan Coin
Correlates of severe and fatal influenza disease in high-risk groups Head of Laboratory Associate Professor Katherine Kedzierska
Cox laboratory: Metabolic Regulation of Growth Head of Laboratory Dr Andrew Cox
Crack laboratory: Neuropharmacology Head of Laboratory Professor Peter Crack
Peter Crouch laboratory Head of Laboratory Associate Professor Peter Crouch
Deciphering the mysteries of human brain development Project Leader Dr Mike Clark
Deciphering the relative contributions of different dendritic cells to killer T cell responses Project Leader Professor Sammy Bedoui
Defining new roles for the Hippo signalling pathway in skeletal muscle Research Project Leader Associate Professor Paul Gregorevic
Delbridge & Weeks laboratory: Cardiac Phenomics & Signalling Head of Laboratory Professor Lea Delbridge
Co-Lead of Laboratory Dr Kate Weeks
Delineating how CD4 T cells ‘help’ establishing effective killer T cell responses Project Leader Professor Sammy Bedoui
Dendritic cell maturation following different microbial stimulation Project Leader Professor William (Bill) Heath
Design, development and testing of HIV vaccines Project Leader Professor Damian Purcell
Developing a novel class of therapeutics for muscle wasting and frailty Research Project Leader Dr Benjamin Parker
Developing innovative animal and cell culture models to study and treat muscular dystrophies Research Project Leader Associate Professor Paul Gregorevic
Development of autonomic and nociceptive circuits Project Leaders Professor Janet Keast / Dr Peregrine Osborne
Development of effector regulatory T cells Project Leader Professor Axel Kallies
Development of new types of antimicrobial agents Project Leader Professor Roy Robins-Browne
Diabetic cardiomyopathy – an epidemic disease Research Project Leader Professor Lea Delbridge
Dr Kate Weeks
Discovering and characterizing new genes involved in innate immunity, tissue injury and fibrosis Project Leader Professor Christine Wells
Towards understanding new therapies for obesity and diabetes: discovering new regulators of lipid metabolism Research Project Leader Professor Matthew Watt
Dodd laboratory: Metabolic Neuroscience Head of Laboratory A/Prof Garron Dodd
Edgington-Mitchell laboratory: Protease pathophysiology Head of Research Group A/Prof Laura Edgington-Mitchell
EMT regulators in intestinal and germline stem cells Project Leader Professor Gary Hime
Enterococcus faecium Project Leader Professor Ben Howden
Exercise-induced liver-muscle cross-talk and mitochondrial adaptations Research Project Leader Dr Magdalene Montgomery
Exploring new roles for the TGFβ signalling network as a key regulator of skeletal muscle in health and disease Research Project Leader Associate Professor Paul Gregorevic
Factors that accelerate photoreceptor death: The role of purines Head of Laboratory Professor Erica Fletcher
Fletcher laboratory: Visual neuroscience Head of Laboratory Professor Erica Fletcher
Functional neuroanatomy of genitourinary vasculature Project Leaders Professor Janet Keast / Dr Peregrine Osborne
Furness laboratory: Digestive physiology and nutrition Head of Laboratory Professor John Furness
Gebhardt laboratory: Adaptive immune responses to virus infections Head of Laboratory Professor Thomas Gebhardt
Genetics of blood brain barrier formation Project Leader Professor Ben Hogan
Ghosal laboratory: In situ structural biology Head of Laboratory Dr Debnath Ghosal
Gleeson laboratory: Membrane trafficking in the secretory and endocytic pathways in health and disease. Head of Laboratory Professor Paul Gleeson
Glial cells as a source of progenitor cells in degenerative disease Head of Laboratory Professor Erica Fletcher
Godfrey laboratory: The development and function of unconventional T cells Head of Laboratory Professor Dale Godfrey
Gooley laboratory: Receptor structural biology Head of Laboratory Professor Paul Gooley
Gregorevic laboratory: Muscle Research and Therapeutics Head of Laboratory Professor Paul Gregorevic
Griffin laboratory: Protein biophysics and structural biology Head of Laboratory Dr Michael Griffin
Gunnersen laboratory: Neuron development and plasticity Head of Laboratory Associate Professor Jenny Gunnersen
Haque Laboratory Head of Laboratory Associate Professor Ashraful Haque
Harnessing local immunity to block the development of secondary bacterial pneumonia Project Leader Dr Linda Wakim
Hatters laboratory: Molecular mechanisms of neurodegeneration Head of Laboratory Professor Danny Hatters
Heath laboratory: CD8 T lymphocytes, dendritic cells, self tolerance and immunity Head of Laboratory Professor William (Bill) Heath
Hime laboratory: Stem cell genetics and Drosophila models of human disease Head of Laboratory Professor Gary Hime
Hogan laboratory: Vascular Cell and Developmental Biology Head of Laboratory Professor Ben Hogan
How do dietary nutrients affect the ability of stem cells and stem cell-derived tumours to grow and divide? Project Leader A/Professor Louise Cheng
How do neural stem cells maintain quiescence? Project Leader A/Professor Louise Cheng
How do neurons maintain their specialised status? Project Leader A/Professor Louise Cheng
How do our genes cause neuropsychiatric disorders? Project Leader Dr Mike Clark
How do tumours compete for resources to grow? Project Leader A/Professor Louise Cheng
How does GM-CSF prevent brain damage after traumatic injury? Head of Laboratory Dr Jenny Gunnersen
Project Leader Dr Sandy Shultz
How is the immunological T cell memory generated? Project Leader Associate Professor Katherine Kedzierska
Howden laboratory: Molecular epidemiology, genomics and pathogenesis of antimicrobial resistant bacteria Head of Laboratory | Director of MDU Professor Ben Howden
Hoyer laboratory: Translational neuropharmacology Head of Laboratory Professor Daniel Hoyer
Human brain networks processing respiratory sensations Project Leader Professor Stuart Mazzone
Hypothalamic modulation of basal sympathetic activity Research Project Leader Professor Andrew Allen
Identifying factors that improve gastrointestinal function in Duchenne's muscular dystrophy Research Project Leader Professor Gordon Lynch
Identifying the mechanisms of immune cell development in peripheral tissues Project Leader Professor Laura Mackay
Imaging effector and memory T cell responses in the skin following Herpes Simplex Virus-1 infection Project Leader Professor William (Bill) Heath
Imaging the priming of CD8 Killer T cell responses to Herpes Simplex Virus-1 skin infection Project Leader Professor William (Bill) Heath
Improved vaccines by targeting to dendritic cells Project Leader Professor William (Bill) Heath
Influenza A virus PB1-F2 Protein: a putative virulence factor and initiator of inflammation Project Leader Dr Julie McAuley
Influenza and HIV vaccines and the importance of mucosal immunity Project Leader Professor Stephen Kent
Influenza–specific ADCC: Role in a universal flu vaccine? Project Leader Professor Stephen Kent
Innate immunity and neural injury Head of Laboratory Associate Professor Peter Crack
Innate T cell recognition and development Project Leader Dr Daniel Pellicci
Insulin on the Brain Research Project Leader Dr Garron Dodd
Intraepithelial T cells in anti-viral immunity Project Leader Professor Francis (Frank) Carbone
Intravital imaging of T cell responses in the brain during cerebral malaria infection Project Leader Professor William (Bill) Heath
Investigating the Dystrophin-Glycoprotein Complex to Protect Muscles from Wasting Conditions Research Project Leader Professor Gordon Lynch
Investigating the mechanism of action of the antiviral molecule, IFITM3 Project Leader Dr Linda Wakim
Investigating the role of cachexia in the response to surgical tumour resection in mice Research Project Leader Professor Gordon Lynch
Investigation of HSV latency and reactivation Project Leader Professor Francis (Frank) Carbone
Is the “shed” form of Sez-6 proteins responsible for their synapse-promoting effects? Head of Laboratory Dr Jenny Gunnersen
Project Leader Dr Kathryn Munro
Ivanusic laboratory: Pain and sensory mechanisms Head of Laboratory Professor Jason Ivanusic
Kallies laboratory: Molecular immunology Head of Laboratory Professor Axel Kallies
Keast-Osborne Laboratory: Neural and Bioelectronic Control of Pelvic Organs Joint Head of Lab Prof Janet Keast
Joint Head of Lab A/Prof Peregrine Osborne
Kedzierska laboratory: Immunity to pandemic and newly emerged influenza viruses Head of Laboratory Associate Professor Katherine Kedzierska
Keenan laboratory: Epigenetic regulation of immunity and disease Head of Laboratory Dr Christine Keenan
Kent laboratory: HIV vaccines; immune responses to HIV-1; immunotherapy Head of Laboratory Professor Stephen Kent
Klebsiella pneumoniae Project Leader Professor Dick Strugnell
Lawson laboratory: Transmissible neurodegeneration Head of Laboratory Associate Professor Vicki Lawson
Learning from skeletal muscles to develop new treatments for cancer Research Project Leader Associate Professor Paul Gregorevic
Live imaging of cellular signalling in vascular development and disease models Project Leader Professor Ben Hogan
Lung Disease Research Laboratory Head of Laboratory Professor Gary P Anderson
Lynch laboratory: Basic and clinical myology Head of Laboratory Professor Gordon Lynch
Mackay laboratory: Tissue-resident memory T cells; lymphocyte differentiation; peripheral immunity Lab Head, NHMRC Leadership Fellow, Dame Kate Campbell Fellow Professor Laura Mackay FAHMS
Mackenzie laboratory: Intracellular virus replication and innate immunity Head of Laboratory Professor Jason Mackenzie
MAIT cells in homeostasis and microbial infections Researchers Dr Zhenjun Chen, Dr Alexandra Corbett and Dr Sidonia Eckle
Malaria and Tissue Resident Memory T cells (TRM) in the liver Project Leader Professor William (Bill) Heath
Mapping the distribution of angiotensin receptors in the brain Research Project Leader Professor Andrew Allen
Mature and developing synaptic transmission between defined classes of enteric neurons Research Project Leader Dr Jaime Foong
Mazzone laboratory: Respiratory Sensory Neuroscience Head of Research Group Professor Stuart Mazzone
McCluskey laboratory: Role of MAIT cells in health and disease Head of Laboratory Redmond Barry Distinguished Professor James McCluskey
McDevitt laboratory Head of Laboratory Associate Professor Christopher McDevitt
McQuade laboratory: Gut-Barrier & Disease Head of Laboratory Dr Rachel McQuade
Mechanisms of diastolic heart failure Research Project Leader Professor Lea Delbridge
Dr Kate Weeks
Mechanisms underlying early generation of human T cell memory Project Leader Associate Professor Katherine Kedzierska
Memory T cell responses in the lung during virus infection Project Leader Dr Linda Wakim
Metabolic reprogramming of skeletal muscle stem cells Research Project Leader Professor Gordon Lynch
Mintern laboratory: Vaccine and immunotherapy Head of Laboratory Prof Justine Mintern
Molecular and cellular analysis of mammalian ovary development and disease Project Leader Associate Professor Dagmar Wilhelm
Molecular mechanisms controlling lymphangiogenesis Project Leader Professor Ben Hogan
Molecular Mechanisms of Disease
Molecular mechanisms that contribute to skeletal pain Head of Laboratory Professor Jason Ivanusic
Montgomery laboratory: Metabolic Tissue Cross-Talk Head of Laboratory Dr Magdalene Montgomery
Murray laboratory: Myelin biology Head of Laboratory Associate Professor Simon Murray
Muscle wasting in multiple system atrophy Research Project Leader Professor Gordon Lynch
Mycobacterium ulcerans Project Leader Professor TIm Stinear
Nanoparticle HIV vaccines Project Leader Professor Stephen Kent
Nanoparticle Modulation of Mast Cell Function Project Leader Dr Graham Mackay
Neuroanatomy of human visceral systems Professor Janet Keast
Neuropsychiatric disorder gene characterisation with Nanopore sequencing Project Leader Dr Mike Clark
NK cell receptor biology Project Leader Professor Andrew Brooks
Non-classical MHC and Class 1-like molecules Project Leader Professor Andrew Brooks
Non-conventional T cells and HIV: role of NKT cells, MAIT cells, CD-1 restricted and gamma-delta T cells Project Leader Professor Stephen Kent
Norovirus replication and innate immunity Project Leader Professor Jason Mackenzie
Novel Mast Cell-Derived Mediators Project Leader Dr Graham Mackay
Oxidative stress and neural injury Head of Laboratory Associate Professor Peter Crack
Pain management using ultrasound-guided local anaesthetic techniques Head of Laboratory Professor Jason Ivanusic
Parker laboratory: Metabolic Proteomics & Signal Transduction Head of Laboratory A/Prof Benjamin Parker
Parker laboratory: Structural biology and computational Design Head of Laboratory and Director, Bio21 Institute Professor Michael Parker
Passive antibody immunity for use in combination microbicides Project Leader Professor Damian Purcell
Post-translational control of cell fate decisions Project Leader Associate Professor Dagmar Wilhelm
Precursor exhausted T cells in chronic infection and tumors Project Leader Professor Axel Kallies
Prognostic biomarker and therapeutic target discovery in stroke Project Leader Dr Jonathon Mangum
Project 1. How do CD4+ T cells preserve memories during malaria? Head of Laboratory Associate Professor Ashraful Haque
Project 1. Should we worry about prion associated heart disease? Head of Laboratory Associate Professor Vicki Lawson
Project 2. CD4+ T cells in acute Graft-versus-Host Disease Head of Laboratory Associate Professor Ashraful Haque
Project 2. COVID-19 associated brain injury and inflammation Head of Laboratory Associate Professor Vicki Lawson
Project 3. Do malaria parasites sense and respond to the host during infection? Head of Laboratory Associate Professor Ashraful Haque
Purcell laboratory: Viral RNA elements, regulation of HIV replication, HIV antibody vaccine Head of Laboratory Professor Damian Purcell
Ralph laboratory: Antimalarial targets and resistance Head of Laboratory Dr Stuart Ralph
Reading laboratory: Innate immune detection and response to respiratory virus infections Head of Laboratory Associate Professor Patrick Reading
Regulation of Mast Cell Activation Project Leader Dr Graham Mackay
Resident memory T cells (Trm) Project Leader Professor Axel Kallies
RNA mediated control of HIV-1 gene expression Project Leader Professor Damian Purcell
Robins-Browne laboratory: Medical bacteriology, pathogenesis, bacterial genetics, therapeutics Head of Laboratory Professor Roy Robins-Browne
Role of cellular lipids during Flavivirus replication Project Leader Professor Jason Mackenzie
Role of innate signals in inducing protective T cell immunity Project Leader Professor Sammy Bedoui
Ruparelia Laboratory: Muscle Growth, Regeneration and Ageing Head of Laboratory Dr Avnika Ruparelia
Salmonella Typhimurium Project Leader Professor Dick Strugnell
Self-tolerance: Interactions between thymic stroma and dendritic cells Project Leader Professor William (Bill) Heath
Sex, adiposity and cardiac vulnerability Research Project Leader Professor Lea Delbridge
Dr Kate Weeks
Sex-specific regulation of adipose tissue immune cells Project Leader Professor Axel Kallies
Shakeel laboratory: Structural genome regulation Lab Head & Principal Research Fellow A/Prof Shabih Shakeel
Skeletal muscle signal transduction related to exercise, metabolic disease and human health Research Project Leader Dr Benjamin Parker
Smith laboratory: Cardiac Genetics Head of Laboratory Associate Professor Kelly Smith
Soluble barriers to influenza virus infection Project Leader Associate Professor Patrick Reading
Solving a Major Complication of Parkinson’s Disease: Targeting Debilitating Constipation Through Novel Pharmacology Joint Heads of Laboratory Professor John Furness & Dr Myat Noe (Cherish) Han
Staphylococcus aureus & Enterococcus faecium Project Leader Professor Tim Stinear
Staphylococcus aureus and Staphylococcus epidermidis Project Leader Professor Ben Howden
Stojanovski laboratory: Mitochondrial biology and disease Head of Laboratory Professor Diana Stojanovski
Stroke Head of Laboratory Associate Professor Peter Crack
Stroud laboratory: Rare disease functional genomics Head of Research Group A/Prof David Stroud
Structure and function of bacterial "cytomotive" filaments Project Leader Dr Debnath Ghosal
Strugnell laboratory: Bacterial pathogenesis and host responses Head of Laboratory Professor Dick Strugnell
Systems genetics of muscle metabolism Research Project Leader Dr Benjamin Parker
T cells in peripheral immunity Project Leader Professor Francis (Frank) Carbone
The Bonn and Melbourne Research and Graduate School Melbourne Coordinator Dr Marie Greyer
The Enteric Neural Circuitry Activated During Bacterial-toxin Induced Diarrhoea Research Project Leader Dr Jaime Foong
The heart as a central player in tissue cross-talk Research Project Leader Dr Magdalene Montgomery
The mechanisms of viral escape in murine and human influenza infection Project Leader Associate Professor Katherine Kedzierska
The role of CD4+ T cells in viral infections Project Leader Professor Andrew Brooks
The Role of enteric neurons in gastrointestinal symptoms associated with Autism Spectrum disorders Research Project Leader Dr Elisa Hill-Yardin
The role of glia in inner retinal changes during retinal degeneration Head of Laboratory Professor Erica Fletcher
The role of glial cells in retinal vascular disease Head of Laboratory Professor Erica Fletcher
The role of innate immune cells in protection and pathology during influenza virus infection Project Leader Associate Professor Patrick Reading
The role of microglia in age-related macular degeneration Head of Laboratory Professor Erica Fletcher
The role of protein modifications on muscle development Research Project Leader Dr Benjamin Parker
The role of the prorenin receptor in male and female fertility Project Leader Associate Professor Dagmar Wilhelm
The role of tissue-resident memory T cells in barrier immunity, cancer and autoimmune diseases Project Leader Professor Laura Mackay
The roles of metal ions in host-pathogen interaction Research Project Leader Associate Professor Christopher McDevitt
Therapeutic potential of skeletal muscle plasticity and slow muscle programming for muscular dystrophy Research Project Leader Professor Gordon Lynch
Tissue communication in non-alcoholic fatty liver disease (NALFD) and liver fibrosis Research Project Leader Dr Magdalene Montgomery
Tracking phenotypically and functionally distinct T cell subsets via T cell repertoire diversity Project Leader Associate Professor Katherine Kedzierska
Transcriptional profiling of sensory neurons Project Leader Professor Stuart Mazzone
Transcriptional reprogramming of metabolism in liver cancer Project Leader Dr Andrew Cox
Traumatic brain injury Head of Laboratory Associate Professor Peter Crack
Uncovering the interplay between innate immunity and the blood brain barrier in disorders of the CNS Project Leader Professor Christine Wells
Understanding how metal ions traverse bacterial cell membranes Research Project Leader Associate Professor Christopher McDevitt
Understanding metabolic cross-talk in health and disease - Focus on type 2 diabetes and fatty liver Research Project Leader Dr Magdalene Montgomery
Understanding the aetiology of hypertension Research Project Leader Professor Andrew Allen
Understanding the fate decisions that govern memory T cell development Project Leader Professor Laura Mackay
Understanding the interaction between microbiota and T cell immunity Project Leader Professor Sammy Bedoui
Understanding the role of angiotensin in the rostral ventrolateral medulla Research Project Leader Professor Andrew Allen
Understanding ‘universal’ influenza-specific CD8+ T cell responses Project Leader Associate Professor Katherine Kedzierska
Unravelling the mysteries of E3 ubiquitin ligase in regulating skeletal muscle size and function Research Project Leader Associate Professor Paul Gregorevic
Vaccination against liver-stage Plasmodium for malaria prevention Project Leader Professor William (Bill) Heath
Villadangos laboratory: Immunology and cell biology Head of Laboratory Professor Jose Villadangos
Viral interactions with the innate immune system Project Leader Associate Professor Patrick Reading
Visualization and formation West Nile Virus replication complexes Project Leader Professor Jason Mackenzie
Wakim laboratory: Antiviral molecules, mucosal immunology, influenza virus, tissue resident memory T cells Head of Laboratory Dr Linda Wakim
Watt laboratory: Metabolism and Diabetes Head of Laboratory Professor Matthew Watt
West Nile Virus replication and cellular stress responses Project Leader Professor Jason Mackenzie
What is the function of Sez6L2 in the forebrain? Head of Laboratory Dr Jenny Gunnersen
Project Leader Dr Kathryn Munro
Whole body analysis of human T cell development and function Project Leader Professor Laura Mackay
Wilhelm laboratory: Gonad Development and Fertility Head of Laboratory Associate Professor Dagmar Wilhelm

221

Biomedical Neuroscience

Groups / Projects Research Lead Dept / Centre
Understanding the plasticity of skeletal muscle in health and disease Research Project Leader Professor Gordon Lynch
A gut feeling about new therapies for glioma Joint Project Leaders Dr Lincon Stamp & Dr Marlene Hao
Allen laboratory: Central cardiovascular regulation Head of Laboratory Professor Andrew Allen
Angiotensin and chemoreceptor function Research Project Leader Professor Andrew Allen
Autologous stem cell therapies in Australia Project Leader Professor Megan Munsie
Biomedical Neuroscience
Blood Atlas: Understanding cell state and differentiation using genomics data from blood cells Project Leader Professor Christine Wells
Bornstein laboratory: Enteric neuroscience Head of Laboratory Professor Joel C Bornstein
Brain networks processing respiratory sensations Project Leader Professor Stuart Mazzone
Building a urogenital nervous system connectome Project Leaders Professor Janet Keast / Dr Peregrine Osborne
Cell state and cell fate: Systems biology approaches to understanding cell identity Project Leader Professor Christine Wells
Cheng laboratory: Stem cell and organ size control regulation Head of Laboratory Associate Professor Louise Cheng
Clark laboratory: Transcriptomics and Neurogenetics Head of Laboratory Dr Mike Clark
Coding the future: next-gen bioinformatic tools for nanopore data Project Leader Dr Mike Clark
Contemplating stem cells in society Project Leader Dr Claire Tanner
Control of colon function in health and disease Project Leader/Supervisor Professor John Furness, Dr Madeleine Di Natale
Crack laboratory: Neuropharmacology Head of Laboratory Professor Peter Crack
Peter Crouch laboratory Head of Laboratory Associate Professor Peter Crouch
Deciphering the mysteries of human brain development Project Leader Dr Mike Clark
Defining new roles for the Hippo signalling pathway in skeletal muscle Research Project Leader Associate Professor Paul Gregorevic
Developing innovative animal and cell culture models to study and treat muscular dystrophies Research Project Leader Associate Professor Paul Gregorevic
Towards understanding new therapies for obesity and diabetes: discovering new regulators of lipid metabolism Research Project Leader Professor Matthew Watt
Disorders of the stomach, gastroparesis and other challenges Project Leader/Supervisor Dr Madeleine Di Natale, Professor John Furness
Exercise-induced liver-muscle cross-talk and mitochondrial adaptations Research Project Leader Dr Magdalene Montgomery
Exploring new roles for the TGFβ signalling network as a key regulator of skeletal muscle in health and disease Research Project Leader Associate Professor Paul Gregorevic
Factors that accelerate photoreceptor death: The role of purines Head of Laboratory Professor Erica Fletcher
Fletcher laboratory: Visual neuroscience Head of Laboratory Professor Erica Fletcher
Functional neuroanatomy of genitourinary vasculature Project Leaders Professor Janet Keast / Dr Peregrine Osborne
Furness laboratory: Digestive physiology and nutrition Head of Laboratory Professor John Furness
Genetics of blood brain barrier formation Project Leader Professor Ben Hogan
Glial cells as a source of progenitor cells in degenerative disease Head of Laboratory Professor Erica Fletcher
Gooley laboratory: Receptor structural biology Head of Laboratory Professor Paul Gooley
Gregorevic laboratory: Muscle Research and Therapeutics Head of Laboratory Professor Paul Gregorevic
Griffin laboratory: Protein biophysics and structural biology Head of Laboratory Dr Michael Griffin
Growth factors and peptide mimetics Project Leader Dr Susan Northfield
Gunnersen laboratory: Neuron development and plasticity Head of Laboratory Associate Professor Jenny Gunnersen
Gut-brain communication: How the stomach and brain communicate Project Leader/Supervisor Dr Madeleine Di Natale, Professor John Furness
Hatters laboratory: Molecular mechanisms of neurodegeneration Head of Laboratory Professor Danny Hatters
Hogan laboratory: Vascular Cell and Developmental Biology Head of Laboratory Professor Ben Hogan
How do dietary nutrients affect the ability of stem cells and stem cell-derived tumours to grow and divide? Project Leader A/Professor Louise Cheng
How do neural stem cells maintain quiescence? Project Leader A/Professor Louise Cheng
How do neurons maintain their specialised status? Project Leader A/Professor Louise Cheng
How do our genes cause neuropsychiatric disorders? Project Leader Dr Mike Clark
How do tumours compete for resources to grow? Project Leader A/Professor Louise Cheng
How does GM-CSF prevent brain damage after traumatic injury? Head of Laboratory Dr Jenny Gunnersen
Project Leader Dr Sandy Shultz
Hoyer laboratory: Translational neuropharmacology Head of Laboratory Professor Daniel Hoyer
Human brain networks processing respiratory sensations Project Leader Professor Stuart Mazzone
Hypothalamic modulation of basal sympathetic activity Research Project Leader Professor Andrew Allen
Identifying factors that improve gastrointestinal function in Duchenne's muscular dystrophy Research Project Leader Professor Gordon Lynch
Innate immunity and neural injury Head of Laboratory Associate Professor Peter Crack
Insulin on the Brain Research Project Leader Dr Garron Dodd
Is the “shed” form of Sez-6 proteins responsible for their synapse-promoting effects? Head of Laboratory Dr Jenny Gunnersen
Project Leader Dr Kathryn Munro
Ivanusic laboratory: Pain and sensory mechanisms Head of Laboratory Professor Jason Ivanusic
Keast-Osborne Laboratory: Neural and Bioelectronic Control of Pelvic Organs Joint Head of Lab Prof Janet Keast
Joint Head of Lab A/Prof Peregrine Osborne
Lawson laboratory: Transmissible neurodegeneration Head of Laboratory Associate Professor Vicki Lawson
Learning from skeletal muscles to develop new treatments for cancer Research Project Leader Associate Professor Paul Gregorevic
Live imaging of cellular signalling in vascular development and disease models Project Leader Professor Ben Hogan
Mapping the distribution of angiotensin receptors in the brain Research Project Leader Professor Andrew Allen
Mature and developing synaptic transmission between defined classes of enteric neurons Research Project Leader Dr Jaime Foong
Mazzone laboratory: Respiratory Sensory Neuroscience Head of Research Group Professor Stuart Mazzone
McQuade laboratory: Gut-Barrier & Disease Head of Laboratory Dr Rachel McQuade
Menden laboratory: Computational biomedicine Head of Laboratory Michael P. Menden
Molecular mechanisms controlling lymphangiogenesis Project Leader Professor Ben Hogan
Molecular mechanisms that contribute to skeletal pain Head of Laboratory Professor Jason Ivanusic
Montgomery laboratory: Metabolic Tissue Cross-Talk Head of Laboratory Dr Magdalene Montgomery
Mueller laboratory: Visualising the immune system in action Head of Laboratory Professor Scott Mueller
Murray laboratory: Myelin biology Head of Laboratory Associate Professor Simon Murray
Muscle wasting in multiple system atrophy Research Project Leader Professor Gordon Lynch
Neural control of intestinal inflammation – therapies for inflammatory bowel disease Project Leader/Supervisor Professor John Furness, Dr Madeleine Di Natale
Neuroanatomy of human visceral systems Professor Janet Keast
Neuropsychiatric disorder gene characterisation with Nanopore sequencing Project Leader Dr Mike Clark
Novel heteromeric receptors: ghrelin receptors and dopamine receptors working together Project Leader/Supervisor Professor John Furness
Novel technique to determine the pKA of clonidine at prejunctional α2-adrenoceptors in sympathetic transmission Project Leader Professor James Angus
Oxidative stress and neural injury Head of Laboratory Associate Professor Peter Crack
Pain management using ultrasound-guided local anaesthetic techniques Head of Laboratory Professor Jason Ivanusic
Parker laboratory: Structural biology and computational Design Head of Laboratory and Director, Bio21 Institute Professor Michael Parker
Patient voices: An analysis of patients’ information-based priorities and needs Project Leader Professor Megan Munsie
Prognostic biomarker and therapeutic target discovery in stroke Project Leader Dr Jonathon Mangum
Project 1. Should we worry about prion associated heart disease? Head of Laboratory Associate Professor Vicki Lawson
Project 2. COVID-19 associated brain injury and inflammation Head of Laboratory Associate Professor Vicki Lawson
Relaxin family peptide hormones Project Leader Associate Professor Tony Hughes
Rouiller laboratory: Molecular nanomachines and mechanisms of disease Associate Professor Isabelle Rouiller
Ruparelia Laboratory: Muscle Growth, Regeneration and Ageing Head of Laboratory Dr Avnika Ruparelia
Scott Laboratory: Neural Circuits and Behaviour Head of Laboratory Professor Ethan Scott
Solving a Major Complication of Parkinson’s Disease: Targeting Debilitating Constipation Through Novel Pharmacology Joint Heads of Laboratory Professor John Furness & Dr Myat Noe (Cherish) Han
Stamp & Hao laboratory: Plasticity of the enteric nervous system Joint Heads of Laboratory Dr Lincon Stamp & Dr Marlene Hao
Stroke Head of Laboratory Associate Professor Peter Crack
The Enteric Neural Circuitry Activated During Bacterial-toxin Induced Diarrhoea Research Project Leader Dr Jaime Foong
The heart as a central player in tissue cross-talk Research Project Leader Dr Magdalene Montgomery
The INSL5/ relaxin (RXFP4) receptor axis: How the large intestine is controlled Project Leader/Supervisor Professor John Furness
The link between cardiovascular disease and neurodegeneration – focus on Alzheimer’s disease Project Leader Associate Professor Christine Wright
The Role of enteric neurons in gastrointestinal symptoms associated with Autism Spectrum disorders Research Project Leader Dr Elisa Hill-Yardin
The role of glia in inner retinal changes during retinal degeneration Head of Laboratory Professor Erica Fletcher
The role of glial cells in retinal vascular disease Head of Laboratory Professor Erica Fletcher
The role of microglia in age-related macular degeneration Head of Laboratory Professor Erica Fletcher
The Stemformatics Stem Cell Atlas Project Leader Professor Christine Wells
Tissue communication in non-alcoholic fatty liver disease (NALFD) and liver fibrosis Research Project Leader Dr Magdalene Montgomery
Transcriptional profiling of sensory neurons Project Leader Professor Stuart Mazzone
Traumatic brain injury Head of Laboratory Associate Professor Peter Crack
Understanding metabolic cross-talk in health and disease - Focus on type 2 diabetes and fatty liver Research Project Leader Dr Magdalene Montgomery
Understanding the aetiology of hypertension Research Project Leader Professor Andrew Allen
Understanding the role of angiotensin in the rostral ventrolateral medulla Research Project Leader Professor Andrew Allen
Unravelling the complexities of the stomach’s control systems Project Leader/Supervisor Dr Madeleine Di Natale, Professor John Furness
Unravelling the mysteries of E3 ubiquitin ligase in regulating skeletal muscle size and function Research Project Leader Associate Professor Paul Gregorevic
What is the function of Sez6L2 in the forebrain? Head of Laboratory Dr Jenny Gunnersen
Project Leader Dr Kathryn Munro
Wilkinson-Berka laboratory: Retinal vascular biology and inflammation Head of Laboratory Professor Jennifer Wilkinson-Berka
Yao laboratory: Cardiovascular Neuroscience Head of Laboratory Dr Song Yao

107

Stem Cells

Groups / Projects Research Lead Dept / Centre
A gut feeling about new therapies for glioma Joint Project Leaders Dr Lincon Stamp & Dr Marlene Hao
Analysing genetic roles of RNA-binding proteins and alternative splicing in Drosophila stem cells Project Leader Professor Gary Hime
Autologous stem cell therapies in Australia Project Leader Professor Megan Munsie
Blood Atlas: Understanding cell state and differentiation using genomics data from blood cells Project Leader Professor Christine Wells
Cell state and cell fate: Systems biology approaches to understanding cell identity Project Leader Professor Christine Wells
Cellular trafficking and male fertility Project Leader Professor Gary Hime
Cheng laboratory: Stem cell and organ size control regulation Head of Laboratory Associate Professor Louise Cheng
Clark laboratory: Transcriptomics and Neurogenetics Head of Laboratory Dr Mike Clark
Coding the future: next-gen bioinformatic tools for nanopore data Project Leader Dr Mike Clark
Contemplating stem cells in society Project Leader Dr Claire Tanner
Deciphering the mysteries of human brain development Project Leader Dr Mike Clark
Eckersley-Maslin laboratory: Stem cell and cancer epigenetics Head of Laboratory Dr Melanie Eckersley-Maslin
EMT regulators in intestinal and germline stem cells Project Leader Professor Gary Hime
Hime laboratory: Stem cell genetics and Drosophila models of human disease Head of Laboratory Professor Gary Hime
How do our genes cause neuropsychiatric disorders? Project Leader Dr Mike Clark
Investigating the Dystrophin-Glycoprotein Complex to Protect Muscles from Wasting Conditions Research Project Leader Professor Gordon Lynch
Investigating the role of cachexia in the response to surgical tumour resection in mice Research Project Leader Professor Gordon Lynch
Lynch laboratory: Basic and clinical myology Head of Laboratory Professor Gordon Lynch
Metabolic reprogramming of skeletal muscle stem cells Research Project Leader Professor Gordon Lynch
Molecular and cellular analysis of mammalian ovary development and disease Project Leader Associate Professor Dagmar Wilhelm
Munsie laboratory: Ethical, legal and social implications of stem cell research Head of Laboratory Professor Megan Munsie
Neuropsychiatric disorder gene characterisation with Nanopore sequencing Project Leader Dr Mike Clark
Novel regulators of germline stem cells Project Leader Professor Gary HIme
Patient voices: An analysis of patients’ information-based priorities and needs Project Leader Professor Megan Munsie
Ruparelia Laboratory: Muscle Growth, Regeneration and Ageing Head of Laboratory Dr Avnika Ruparelia
Stamp & Hao laboratory: Plasticity of the enteric nervous system Joint Heads of Laboratory Dr Lincon Stamp & Dr Marlene Hao
Stem Cells
The Stemformatics Stem Cell Atlas Project Leader Professor Christine Wells
Transcriptional regulation of intestinal organoid differentiation Project Leader Professor Gary Hime
Wells laboratory: Stem cell systems Head of Laboratory Professor Christine Wells

30

Systems Biology

Groups / Projects Research Lead Dept / Centre
Application of genomics to public health and clinical microbiology Project Leader Professor Ben Howden
Blood Atlas: Understanding cell state and differentiation using genomics data from blood cells Project Leader Professor Christine Wells
Brown laboratory: Behavioural neuropharmacology Head of Laboratory Dr Robyn M Brown
Cell state and cell fate: Systems biology approaches to understanding cell identity Project Leader Professor Christine Wells
Clark laboratory: Transcriptomics and Neurogenetics Head of Laboratory Dr Mike Clark
Clinical Proteomics Project Leader Dr Jonathon Mangum
Coding the future: next-gen bioinformatic tools for nanopore data Project Leader Dr Mike Clark
Deciphering the mysteries of human brain development Project Leader Dr Mike Clark
Delbridge & Weeks laboratory: Cardiac Phenomics & Signalling Head of Laboratory Professor Lea Delbridge
Co-Lead of Laboratory Dr Kate Weeks
Developing a novel class of therapeutics for muscle wasting and frailty Research Project Leader Dr Benjamin Parker
Diabetic cardiomyopathy – an epidemic disease Research Project Leader Professor Lea Delbridge
Dr Kate Weeks
Towards understanding new therapies for obesity and diabetes: discovering new regulators of lipid metabolism Research Project Leader Professor Matthew Watt
Enterococcus faecium Project Leader Professor Ben Howden
Exercise-induced liver-muscle cross-talk and mitochondrial adaptations Research Project Leader Dr Magdalene Montgomery
Functional neuroanatomy of genitourinary vasculature Project Leaders Professor Janet Keast / Dr Peregrine Osborne
Harrap laboratory: Genetic physiology Head of Laboratory Professor Stephen Harrap
Hatters laboratory: Molecular mechanisms of neurodegeneration Head of Laboratory Professor Danny Hatters
How do dietary nutrients affect the ability of stem cells and stem cell-derived tumours to grow and divide? Project Leader A/Professor Louise Cheng
How do neural stem cells maintain quiescence? Project Leader A/Professor Louise Cheng
How do neurons maintain their specialised status? Project Leader A/Professor Louise Cheng
How do our genes cause neuropsychiatric disorders? Project Leader Dr Mike Clark
How do tumours compete for resources to grow? Project Leader A/Professor Louise Cheng
Howden laboratory: Molecular epidemiology, genomics and pathogenesis of antimicrobial resistant bacteria Head of Laboratory | Director of MDU Professor Ben Howden
Ivanusic laboratory: Pain and sensory mechanisms Head of Laboratory Professor Jason Ivanusic
Keast-Osborne Laboratory: Neural and Bioelectronic Control of Pelvic Organs Joint Head of Lab Prof Janet Keast
Joint Head of Lab A/Prof Peregrine Osborne
McConville laboratory: Microbial Metabolism Head of Laboratory Professor Malcolm McConville
McQuade laboratory: Gut-Barrier & Disease Head of Laboratory Dr Rachel McQuade
Mechanisms of diastolic heart failure Research Project Leader Professor Lea Delbridge
Dr Kate Weeks
Menden laboratory: Computational biomedicine Head of Laboratory Michael P. Menden
Molecular mechanisms that contribute to skeletal pain Head of Laboratory Professor Jason Ivanusic
Montgomery laboratory: Metabolic Tissue Cross-Talk Head of Laboratory Dr Magdalene Montgomery
Mycobacterium ulcerans Project Leader Professor TIm Stinear
Neuropsychiatric disorder gene characterisation with Nanopore sequencing Project Leader Dr Mike Clark
Pain management using ultrasound-guided local anaesthetic techniques Head of Laboratory Professor Jason Ivanusic
Parker laboratory: Metabolic Proteomics & Signal Transduction Head of Laboratory A/Prof Benjamin Parker
Scott Laboratory: Microbial glycoproteomics and host pathogen interactions Head of Laboratory Dr Nichollas Scott
Scott Laboratory: Neural Circuits and Behaviour Head of Laboratory Professor Ethan Scott
Sex, adiposity and cardiac vulnerability Research Project Leader Professor Lea Delbridge
Dr Kate Weeks
Skeletal muscle signal transduction related to exercise, metabolic disease and human health Research Project Leader Dr Benjamin Parker
Staphylococcus aureus & Enterococcus faecium Project Leader Professor Tim Stinear
Staphylococcus aureus and Staphylococcus epidermidis Project Leader Professor Ben Howden
Stinear laboratory: Bacterial pathogenomics Head of Laboratory Professor Tim Stinear
Stroud laboratory: Rare disease functional genomics Head of Research Group A/Prof David Stroud
Systems Biology
Systems genetics of muscle metabolism Research Project Leader Dr Benjamin Parker
The Bonn and Melbourne Research and Graduate School Melbourne Coordinator Dr Marie Greyer
The heart as a central player in tissue cross-talk Research Project Leader Dr Magdalene Montgomery
The role of protein modifications on muscle development Research Project Leader Dr Benjamin Parker
The Stemformatics Stem Cell Atlas Project Leader Professor Christine Wells
Tissue communication in non-alcoholic fatty liver disease (NALFD) and liver fibrosis Research Project Leader Dr Magdalene Montgomery
Understanding metabolic cross-talk in health and disease - Focus on type 2 diabetes and fatty liver Research Project Leader Dr Magdalene Montgomery
Watt laboratory: Metabolism and Diabetes Head of Laboratory Professor Matthew Watt
Wells laboratory: Stem cell systems Head of Laboratory Professor Christine Wells

53

Therapeutics & Translation

Groups / Projects Research Lead Dept / Centre
Autologous stem cell therapies in Australia Project Leader Professor Megan Munsie
Brown laboratory: Behavioural neuropharmacology Head of Laboratory Dr Robyn M Brown
Contemplating stem cells in society Project Leader Dr Claire Tanner
Crack laboratory: Neuropharmacology Head of Laboratory Professor Peter Crack
Defining new roles for the Hippo signalling pathway in skeletal muscle Research Project Leader Associate Professor Paul Gregorevic
Developing innovative animal and cell culture models to study and treat muscular dystrophies Research Project Leader Associate Professor Paul Gregorevic
Towards understanding new therapies for obesity and diabetes: discovering new regulators of lipid metabolism Research Project Leader Professor Matthew Watt
Dolcetti Laboratory: Clinical and Translational Immunotherapy Head of Laboratory Professor Riccardo Dolcetti
Edgington-Mitchell laboratory: Protease pathophysiology Head of Research Group A/Prof Laura Edgington-Mitchell
Endothelin pharmacology in the setting of pulmonary hypertension Project Leader Professor James Angus
Exercise-induced liver-muscle cross-talk and mitochondrial adaptations Research Project Leader Dr Magdalene Montgomery
Exploring new roles for the TGFβ signalling network as a key regulator of skeletal muscle in health and disease Research Project Leader Associate Professor Paul Gregorevic
Furness laboratory: Digestive physiology and nutrition Head of Laboratory Professor John Furness
Gleeson laboratory: Membrane trafficking in the secretory and endocytic pathways in health and disease. Head of Laboratory Professor Paul Gleeson
Gooley laboratory: Receptor structural biology Head of Laboratory Professor Paul Gooley
Gregorevic laboratory: Muscle Research and Therapeutics Head of Laboratory Professor Paul Gregorevic
Growth factors and peptide mimetics Project Leader Dr Susan Northfield
Hoyer laboratory: Translational neuropharmacology Head of Laboratory Professor Daniel Hoyer
Ivanusic laboratory: Pain and sensory mechanisms Head of Laboratory Professor Jason Ivanusic
Keenan laboratory: Epigenetic regulation of immunity and disease Head of Laboratory Dr Christine Keenan
Learning from skeletal muscles to develop new treatments for cancer Research Project Leader Associate Professor Paul Gregorevic
McQuade laboratory: Gut-Barrier & Disease Head of Laboratory Dr Rachel McQuade
Molecular mechanisms of drug resistance in cancer Project Leader Dr Jonathon Mangum
Molecular mechanisms that contribute to skeletal pain Head of Laboratory Professor Jason Ivanusic
Montgomery laboratory: Metabolic Tissue Cross-Talk Head of Laboratory Dr Magdalene Montgomery
Munsie laboratory: Ethical, legal and social implications of stem cell research Head of Laboratory Professor Megan Munsie
Murray laboratory: Myelin biology Head of Laboratory Associate Professor Simon Murray
Pain management using ultrasound-guided local anaesthetic techniques Head of Laboratory Professor Jason Ivanusic
Parker laboratory: Structural biology and computational Design Head of Laboratory and Director, Bio21 Institute Professor Michael Parker
Patient voices: An analysis of patients’ information-based priorities and needs Project Leader Professor Megan Munsie
Preclinical pharmacology – cardiovascular efficacy and safety R&D Project Leader Associate Professor Christine Wright
Prognostic biomarker and therapeutic target discovery in stroke Project Leader Dr Jonathon Mangum
Project 1. Development of improved cancer vaccines to enhance the efficacy of immunotherapy combination strategies Project Leader Professor Riccardo Dolcetti
Project 2. Identification and characterisation of novel classes of therapeutically relevant tumour neo-antigens Project Leader Professor Riccardo Dolcetti
Ralph laboratory: Antimalarial targets and resistance Head of Laboratory Dr Stuart Ralph
Relaxin family peptide hormones Project Leader Associate Professor Tony Hughes
Ruparelia Laboratory: Muscle Growth, Regeneration and Ageing Head of Laboratory Dr Avnika Ruparelia
Schneider-Futschik laboratory: Rare and complex lung disease Head of Laboratory A/Prof Elena Schneider-Futschik
Lung Health Research Centre
Solving a Major Complication of Parkinson’s Disease: Targeting Debilitating Constipation Through Novel Pharmacology Joint Heads of Laboratory Professor John Furness & Dr Myat Noe (Cherish) Han
Stewart laboratory: Mechanopharmacology, fibrosis and drug development Head of Laboratory Professor Alastair Stewart
The Bonn and Melbourne Research and Graduate School Melbourne Coordinator Dr Marie Greyer
The heart as a central player in tissue cross-talk Research Project Leader Dr Magdalene Montgomery
The link between cardiovascular disease and neurodegeneration – focus on Alzheimer’s disease Project Leader Associate Professor Christine Wright
Therapeutics & Translation
Tilley laboratory: Malaria parasite drug discovery Head of Laboratory, Redmond Barry Distinguished Professor of Biochemistry & Pharmacology, ARC Australian Laureate Fellow (2015-2020) Emeritus Professor Leann Tilley
Tissue communication in non-alcoholic fatty liver disease (NALFD) and liver fibrosis Research Project Leader Dr Magdalene Montgomery
Trovafloxacin – an antibiotic with additional properties Project Leader Professor James Angus
Understanding metabolic cross-talk in health and disease - Focus on type 2 diabetes and fatty liver Research Project Leader Dr Magdalene Montgomery
Unravelling the mysteries of E3 ubiquitin ligase in regulating skeletal muscle size and function Research Project Leader Associate Professor Paul Gregorevic
Watt laboratory: Metabolism and Diabetes Head of Laboratory Professor Matthew Watt
Wheatley Laboratory Head of Laboratory Dr Adam Wheatley
Wilkinson-Berka laboratory: Retinal vascular biology and inflammation Head of Laboratory Professor Jennifer Wilkinson-Berka

52

Scholarship of Teaching and Learning

Groups / Projects Research Lead Dept / Centre
Clark: Anatomy, Neuroscience and Cell Biology Education Scholarship Dr Charlotte Clark
Heather Verkade: Molecular Biology Education Scholarship Associate Professor Heather Verkade
Lim: Education Scholarship Dr Saw Hoon Lim
Rathner & Khammy: Physical Activity and Academic Success - Hiatus
Rathner & Khammy: Physical activity, wellbeing, and belonging – Hiatus
Post: Online Teaching Delivery Neuroscience & Anatomy MSc Ger Post
Rank: Anatomy Education Scholarship Dr Michelle Rank
Anatomy and Neuroscience
Scholarship of Teaching and Learning
Rathner, Khammy, McCarty: Understanding the value of lecture transcripts from a students' perspective – Concluded
Rathner, Khammy, McCarty: Unveiling the effect of transcripts on student learning outcomes - Concluded
Wijburg: Infection and Immunity Education Scholarship Associate Professor Odilia Wijburg
Microbiology and Immunology

11