Biomedical Projects by Theme

Cancer in Biomedicine

Groups / Projects	Research Lead	Dept / Centre
A novel link between metabolism and host defence: O-GlcNAc glycosylation	Professor Jose Villadangos	Biochemistry and Molecular Biology
Analysing genetic roles of RNA-binding proteins and alternative splicing in Drosophila stem cells	Project Leader Professor Gary Hime	Anatomy and Neuroscience
Analysing protein structures	Dr David Ascher	Biochemistry and Molecular Biology
Applications of Nanopore sequencing	Project Leader Dr Mike Clark	Anatomy and Neuroscience
Ascher laboratory: Structural biology and bioinformatics	Head of Laboratory Dr David Ascher	Biochemistry and Molecular Biology
Bo&MeRanG Research Projects	Melbourne Coordinator Dr Marie Greyer
Bogoyevitch laboratory: Regulatory biology	Head of Laboratory Associate Professor Marie Bogoyevitch	Biochemistry and Molecular Biology
Cancer in Biomedicine
Characterising the pathways responsible for ICU-acquired weakness	Research Project Leader Dr René Koopman	Physiology
Cheng laboratory: Molecular enzymology of protein kinases and phosphatases involved in human diseases	Head of Laboratory Associate Professor Heung-Chin Cheng	Biochemistry and Molecular Biology
Cheng laboratory: Stem cell and organ size control regulation	Head of Laboratory Dr Louise Cheng	Anatomy and Neuroscience
Clinical Proteomics	Project Leader Dr Jonathon Mangum	Pharmacology and Therapeutics
Decoding the trafficking of immune receptors	Dr Justine Mintern	Biochemistry and Molecular Biology
Defining new roles for the Hippo signalling pathway in skeletal muscle	Research Project Leader Associate Professor Paul Gregorevic	Physiology
Designing better drugs	Dr David Ascher	Biochemistry and Molecular Biology
Designing new optogenetic tools for biomedical research	A/Prof Danny Hatters	Biochemistry and Molecular Biology
Developing innovative animal and cell culture models to study and treat muscular dystrophies	Research Project Leader Associate Professor Paul Gregorevic	Physiology
Towards understanding new therapies for obesity and diabetes: discovering new regulators of lipid metabolism	Research Project Leader Professor Matthew Watt	Physiology
EMT regulators in intestinal and germline stem cells	Project Leader Professor Gary Hime	Anatomy and Neuroscience
Establishing the effect of glycine/serine metabolism on skeletal muscle cell growth	Research Project Leader Dr René Koopman	Physiology
Exploiting nanoparticles as vaccines	Dr Justine Mintern	Biochemistry and Molecular Biology
Exploring new roles for the TGFβ signalling network as a key regulator of skeletal muscle in health and disease	Research Project Leader Associate Professor Paul Gregorevic	Physiology
Finding clarity within a blizzard- guiding the solution of cryo-EM structures	Dr David Ascher	Biochemistry and Molecular Biology
Gregorevic laboratory: Muscle Research and Therapeutics	Head of Laboratory Associate Professor Paul Gregorevic	Physiology
Hime laboratory: Stem cell genetics and Drosophila models of human disease	Head of Laboratory Professor Gary Hime	Anatomy and Neuroscience
Hinde laboratory: Biophysics of Nuclear Organisation	Head of Research Group Dr Elizabeth Hinde	Biochemistry and Molecular Biology
How do dietary nutrients affect the ability of stem cells and stem cell-derived tumours to grow and divide?	Dr Louise Cheng	Anatomy and Neuroscience
How do neurons maintain their specialised status?	Dr Louise Cheng	Anatomy and Neuroscience
How do tumours compete with other tissues for resources?	Dr Louise Cheng	Anatomy and Neuroscience
How infection and trauma cause dendritic cell paralysis and lethal immunosuppression	Professor Jose Villadangos	Microbiology and Immunology
How to harness the immune system to cure cancer: adoptive cell immunotherapy	Professor Jose Villadangos	Microbiology and Immunology
Immunoregulatory functions of the MARCH family of ubiquitin ligases	Professor Jose Villadangos	Biochemistry and Molecular Biology
Investigating the Dystrophin-Glycoprotein Complex to Protect Muscles from Wasting Conditions	Research Project Leader Professor Gordon Lynch	Physiology
Investigating the role of cachexia in the response to surgical tumour resection in mice	Research Project Leader Professor Gordon Lynch	Physiology
Koopman laboratory: Clinical nutrition and muscle metabolism	Head of Laboratory Dr René Koopman	Physiology
Learning from skeletal muscles to develop new treatments for cancer	Research Project Leader Associate Professor Paul Gregorevic	Physiology
Lynch laboratory: Basic and clinical myology	Head of Laboratory Professor Gordon Lynch	Physiology
Mangum Lab: Translational Proteomics	Head of Laboratory Dr Jonathan Mangum	Pharmacology and Therapeutics
Manipulating immunity to fight infection and tumours	Dr Justine Mintern	Biochemistry and Molecular Biology
Mantamadiotis laboratory: Brain Cancer Molecular Biology	Dr Theo Mantamadiotis	Microbiology and Immunology
Metabolic reprogramming of skeletal muscle stem cells	Research Project Leader Professor Gordon Lynch	Physiology
Molecular basis for growth factor surveillance in natural killer cells	Dr Alexander David Barrow	Microbiology and Immunology
Molecular basis for growth factor surveillance in plasmacytoid dendritic cells	Dr Alexander David Barrow	Microbiology and Immunology
Molecular mechanisms of drug resistance in cancer	Project Leader Dr Jonathon Mangum	Pharmacology and Therapeutics
MR1 – a molecular alarm system that detects pathogen metabolites	Professor Jose Villadangos	Microbiology and Immunology
Mueller laboratory: Visualising the immune system in action	Head of Laboratory Associate Professor Scott Mueller	Microbiology and Immunology
Novel regulators of germline stem cells	Project Leader Professor Gary HIme	Anatomy and Neuroscience
Parker Laboratory: Structural biology and computational drug design	Head of Laboratory and Director, Bio21 Institute Professor Michael Parker	Biochemistry and Molecular Biology
Personalising treatments for genetic diseases	Dr David Ascher	Biochemistry and Molecular Biology
Pébay laboratory: Stem Cell Disease Modelling	Head of Laboratory Professor Alice Pebay	Anatomy and Neuroscience
Rational Protein Engineering	Dr David Ascher	Biochemistry and Molecular Biology
Reid laboratory: Proteomics and lipidomics in health and disease	Head of Laboratory Professor Gavin E. Reid	Biochemistry and Molecular Biology
Restoring immunocompetency in Chronic Lymphocytic Leukemia	Senior Research Officer & Lab Manager Catherine Kennedy, PhD	Microbiology and Immunology
Rouiller laboratory: Understanding how molecular machines function through cryo-electron microscopy	Associate Professor Isabelle Rouiller	Biochemistry and Molecular Biology
Small molecules for BIG targets- Targeting protein-protein interactions with fragments	Dr David Ascher	Biochemistry and Molecular Biology
Structural Biology of Cancer	Professor Michael Parker	Biochemistry and Molecular Biology
Tackling drug resistance	Dr David Ascher	Biochemistry and Molecular Biology
Taylor: Jack Brockhoff Reconstructive Plastic Surgery Research Unit	Head of Research Unit Professor Ian Taylor	Anatomy and Neuroscience
Therapeutic potential of skeletal muscle plasticity and slow muscle programming for muscular dystrophy	Research Project Leader Professor Gordon Lynch	Physiology
Transcriptional regulation of intestinal organoid differentiation	Project Leader Professor Gary Hime	Anatomy and Neuroscience
Understanding how the ATPase p97 functions at molecular level	Associate Professor Isabelle Rouiller	Biochemistry and Molecular Biology
Understanding immune dysfunction in acute myeloid leukemia	Dr Justine Mintern	Biochemistry and Molecular Biology
Understanding the immune microenvironment in brain tumours	Dr Theo Mantamadiotis	Microbiology and Immunology
Understanding the Molecular Consequences of Mutations	Dr David Ascher David Ascher	Biochemistry and Molecular Biology
Unravelling the mysteries of E3 ubiquitin ligase in regulating skeletal muscle size and function	Research Project Leader Associate Professor Paul Gregorevic	Physiology
Using the immune system to kill tumours	Dr Justine Mintern	Biochemistry and Molecular Biology
Using transcriptional analyses to understand recognition of tumours by natural killer cells	Professor Andrew Brooks	Microbiology and Immunology
Watt laboratory: Metabolism and Diabetes	Head of Laboratory Professor Matthew Watt	Physiology

Cardio-Respiratory

Groups / Projects	Research Lead	Dept / Centre
Allen laboratory: Central cardiovascular regulation	Head of Laboratory Professor Andrew Allen	Physiology
Brain networks processing respiratory sensations	Project Leader Associate Professor Stuart Mazzone	Anatomy and Neuroscience
Effects of hypertension on renal and hindquarter vascular reactivity in vivo and in vitro	Project Leader Associate Professor Christine Wright	Pharmacology and Therapeutics
Endothelin pharmacology in the setting of pulmonary hypertension	Project Leader Professor James Angus	Pharmacology and Therapeutics
Functional genomic screens for cardiovascular drug discovery	Research Project Leader Dr Enzo Porrello	Physiology
Human brain networks processing respiratory sensations	Project Leader Associate Professor Stuart Mazzone	Anatomy and Neuroscience
Improving the diagnostic outcomes of patients with mitochondrial disease	Dr David Stroud	Biochemistry and Molecular Biology
Lung Disease Research Laboratory	Head of Laboratory Professor Gary P Anderson	Pharmacology and Therapeutics
Manipulating the endocannabinoid system to alter cardiovascular function in hypertension	Dr Makhala Khammy	Pharmacology and Therapeutics
Mazzone laboratory: Respiratory Sensory Neuroscience	Head of Research Group Associate Professor Stuart Mazzone	Anatomy and Neuroscience
Modeling human heart development using human cardiac organoids	Research Project Leader Dr Enzo Porrello	Physiology
Modelling sensory neuron-epithelial interactions	Project Leader Associate Professor Stuart Mazzone	Anatomy and Neuroscience
Montgomery laboratory: Metabolic Tissue Cross-Talk	Head of Laboratory Dr Magdalene Montgomery	Physiology
Novel technique to determine the pKA of clonidine at prejunctional α2-adrenoceptors in sympathetic transmission	Project Leader Professor James Angus	Pharmacology and Therapeutics
Pathogenesis of chronic lung disease	Head of Laboratory Dr Michelle Hansen	Pharmacology and Therapeutics
Porrello laboratory: Cardiac Regeneration	Head of Laboratory Enzo Porrello	Physiology
Post-natal control of cardiac gene regulatory networks	Research Project Leader Dr Enzo Porrello	Physiology
Preclinical pharmacology – cardiovascular efficacy and safety R&D	Project Leader Associate Professor Christine Wright	Pharmacology and Therapeutics
Reassessment of α1-adrenoceptor mechanism in artery contraction: role of ATP and pannexin channels	Project Leader Professor James Angus	Pharmacology and Therapeutics
Smith laboratory: Cardiac Form and Function	Head of Laboratory Associate Professor Kelly Smith	Physiology
Stroud laboratory: Mitochondrial Systems Biology	Head of Research Group Dr David Stroud	Biochemistry and Molecular Biology
The amyloidogenic protease inhibitor Cystatin C in health and disease	Prof. Jose Villadangos	Biochemistry and Molecular Biology
The cardiovascular pharmacology of snake venoms from Papua New Guinea and Australia	Project Leader Associate Professor Christine Wright	Pharmacology and Therapeutics
The innate immune system in the respiratory tract	Project Leader Professor David Jackson	Microbiology and Immunology
The link between cardiovascular disease and neurodegeneration – focus on Alzheimer’s disease	Project Leader Associate Professor Christine Wright	Pharmacology and Therapeutics
Transcriptional profiling of sensory neurons	Project Leader Associate Professor Stuart Mazzone	Anatomy and Neuroscience
Trovafloxacin – an antibiotic with additional properties	Project Leader Professor James Angus	Pharmacology and Therapeutics
Understanding the assembly of mitochondrial machines	Dr David Stroud	Biochemistry and Molecular Biology
Wlodek laboratory: Fetal, postnatal & adult physiology & disease laboratory	Head of Laboratory Professor Mary Wlodek	Physiology
Wright laboratory: Cardiovascular Therapeutics Unit	Head of Laboratory Associate Professor Christine E Wright	Pharmacology and Therapeutics

Cell Signalling

Groups / Projects	Research Lead	Dept / Centre
A new function of the cytokine BAFF in dendritic cell maturation: Implications for immunity and cancers	Senior Research Officer & Lab Manager Catherine Kennedy, PhD	Microbiology and Immunology
Analysing genetic roles of RNA-binding proteins and alternative splicing in Drosophila stem cells	Project Leader Professor Gary Hime	Anatomy and Neuroscience
Bo&MeRanG Research Projects	Melbourne Coordinator Dr Marie Greyer
Bogoyevitch laboratory: Regulatory biology	Head of Laboratory Associate Professor Marie Bogoyevitch	Biochemistry and Molecular Biology
Cell Signalling
Cellular trafficking and male fertility	Project Leader Professor Gary Hime	Anatomy and Neuroscience
Characterising the pathways responsible for ICU-acquired weakness	Research Project Leader Dr René Koopman	Physiology
Cheng laboratory: Molecular enzymology of protein kinases and phosphatases involved in human diseases	Head of Laboratory Associate Professor Heung-Chin Cheng	Biochemistry and Molecular Biology
Crack laboratory: Neuropharmacology	Head of Laboratory Associate Professor Peter Crack	Pharmacology and Therapeutics
Decoding the trafficking of immune receptors	Dr Justine Mintern	Biochemistry and Molecular Biology
Defining new roles for the Hippo signalling pathway in skeletal muscle	Research Project Leader Associate Professor Paul Gregorevic	Physiology
Designing new optogenetic tools for biomedical research	A/Prof Danny Hatters	Biochemistry and Molecular Biology
Developing a novel class of therapeutics for muscle wasting and frailty	Research Project Leader Dr Benjamin Parker	Physiology
Developing innovative animal and cell culture models to study and treat muscular dystrophies	Research Project Leader Associate Professor Paul Gregorevic	Physiology
Discovering and characterizing new genes involved in innate immunity, tissue injury and fibrosis	Project Leader Professor Christine Wells	Anatomy and Neuroscience
Towards understanding new therapies for obesity and diabetes: discovering new regulators of lipid metabolism	Research Project Leader Professor Matthew Watt	Physiology
Establishing the effect of glycine/serine metabolism on skeletal muscle cell growth	Research Project Leader Dr René Koopman	Physiology
Exercise-induced liver-muscle cross-talk and mitochondrial adaptations	Research Project Leader Dr Magdalene Montgomery	Physiology
Exploiting nanoparticles as vaccines	Dr Justine Mintern	Biochemistry and Molecular Biology
Exploring new roles for the TGFβ signalling network as a key regulator of skeletal muscle in health and disease	Research Project Leader Associate Professor Paul Gregorevic	Physiology
Gleeson laboratory: Membrane trafficking and protein sorting in health and disease and development of new therapeutics	Head of Laboratory Professor Paul Gleeson	Biochemistry and Molecular Biology
Gregorevic laboratory: Muscle Research and Therapeutics	Head of Laboratory Associate Professor Paul Gregorevic	Physiology
Gunnersen laboratory: Neuron development and plasticity	Head of Laboratory Dr Jenny Gunnersen	Anatomy and Neuroscience
Hinde laboratory: Biophysics of Nuclear Organisation	Head of Research Group Dr Elizabeth Hinde	Biochemistry and Molecular Biology
Keast & Osborne laboratory: Neural development, injury and pain	Joint Heads of Laboratory Professor Janet Keast & Dr Peregrine Osborne	Anatomy and Neuroscience
Learning from skeletal muscles to develop new treatments for cancer	Research Project Leader Associate Professor Paul Gregorevic	Physiology
Mantamadiotis laboratory: Brain Cancer Molecular Biology	Dr Theo Mantamadiotis	Microbiology and Immunology
Montgomery laboratory: Metabolic Tissue Cross-Talk	Head of Laboratory Dr Magdalene Montgomery	Physiology
Murray & Xiao laboratory: Neurotrophin and myelin	Joint Heads of Laboratory Dr Simon Murray & Dr Junhua Xiao	Anatomy and Neuroscience
Novel regulators of germline stem cells	Project Leader Professor Gary HIme	Anatomy and Neuroscience
Parker laboratory: Metabolic Proteomics & Signal Transduction	Head of Laboratory Dr Benjamin Parker	Physiology
Skeletal muscle signal transduction related to exercise, metabolic disease and human health	Research Project Leader Dr Benjamin Parker	Physiology
Smith laboratory: Cardiac Form and Function	Head of Laboratory Associate Professor Kelly Smith	Physiology
Structural Biology of Cancer	Professor Michael Parker	Biochemistry and Molecular Biology
Structural Neurobiology	Professor Michael Parker	Biochemistry and Molecular Biology
Systems genetics of muscle metabolism	Research Project Leader Dr Benjamin Parker	Physiology
The GDNF family, peripheral nerve regeneration and pain	Project Leader Professor Janet Keast	Anatomy and Neuroscience
The heart as a central player in tissue cross-talk	Research Project Leader Dr Magdalene Montgomery	Physiology
The Role of CXCR7 in Tissue Fibrosis	Senior Research Officer & Lab Manager Catherine Kennedy, PhD	Microbiology and Immunology
The role of protein modifications on muscle development	Research Project Leader Dr Benjamin Parker	Physiology
The unique features of visceral pain	Project Leader Professor Janet Keast	Anatomy and Neuroscience
Tissue communication in non-alcoholic fatty liver disease (NALFD) and liver fibrosis	Research Project Leader Dr Magdalene Montgomery	Physiology
Transcriptional regulation of intestinal organoid differentiation	Project Leader Professor Gary Hime	Anatomy and Neuroscience
Uncovering the interplay between innate immunity and the blood brain barrier in disorders of the CNS	Project Leader Professor Christine Wells	Anatomy and Neuroscience
Understanding immune dysfunction in acute myeloid leukemia	Dr Justine Mintern	Biochemistry and Molecular Biology
Understanding metabolic cross-talk in health and disease - Focus on type 2 diabetes and fatty liver	Research Project Leader Dr Magdalene Montgomery	Physiology
Understanding the interaction between microbiota and T cell immunity	Project Leader Associate Professor Sammy Bedoui	Microbiology and Immunology
Unravelling the mysteries of E3 ubiquitin ligase in regulating skeletal muscle size and function	Research Project Leader Associate Professor Paul Gregorevic	Physiology
Using the immune system to kill tumours	Dr Justine Mintern	Biochemistry and Molecular Biology
Watt laboratory: Metabolism and Diabetes	Head of Laboratory Professor Matthew Watt	Physiology

Cellular Imaging & Structural Biology

Groups / Projects	Research Lead	Dept / Centre
Adverse maternal environment in females born small and transgenerational consequences	Research Project Leader Professor Mary Wlodek	Physiology
Being born small programs growth restriction, deficits and disease in the next generation	Research Project Leader Professor Mary Wlodek	Physiology
Bo&MeRanG Research Projects	Melbourne Coordinator Dr Marie Greyer
Cellular Imaging & Structural Biology
Dendritic cell maturation following different microbial stimulation	Project Leader Professor William (Bill) Heath	Microbiology and Immunology
Dental morphology	Dr Varsha Pilbrow	Anatomy and Neuroscience
Early life exercise reprograms pancreatic and heart deficits in offspring born small	Research Project Leader Professor Mary Wlodek	Physiology
Factors that accelerate photoreceptor death: The role of purines	Head of Laboratory Professor Erica Fletcher	Anatomy and Neuroscience
Fletcher laboratory: Visual neuroscience	Head of Laboratory Professor Erica Fletcher	Anatomy and Neuroscience
Gleeson laboratory: Membrane trafficking and protein sorting in health and disease and development of new therapeutics	Head of Laboratory Professor Paul Gleeson	Biochemistry and Molecular Biology
Glial cells as a source of progenitor cells in degenerative disease	Head of Laboratory Professor Erica Fletcher	Anatomy and Neuroscience
Gooley laboratory: Structural biology of disease	Head of Laboratory Associate Professor Paul Gooley	Biochemistry and Molecular Biology
Gunnersen laboratory: Neuron development and plasticity	Head of Laboratory Dr Jenny Gunnersen	Anatomy and Neuroscience
Hatters laboratory: Protein misfolding and proteostasis in neurodegenerative diseases	Head of Laboratory Associate Professor Danny Hatters	Biochemistry and Molecular Biology
Heath laboratory: CD8 T lymphocytes, dendritic cells, self tolerance and immunity	Head of Laboratory Professor William (Bill) Heath	Microbiology and Immunology
Hinde laboratory: Biophysics of Nuclear Organisation	Head of Research Group Dr Elizabeth Hinde	Biochemistry and Molecular Biology
Imaging effector and memory T cell responses in the skin following Herpes Simplex Virus-1 infection	Project Leader Professor William (Bill) Heath	Microbiology and Immunology
Imaging the priming of CD8 Killer T cell responses to Herpes Simplex Virus-1 skin infection	Project Leader Professor William (Bill) Heath	Microbiology and Immunology
Improved vaccines by targeting to dendritic cells	Project Leader Professor William (Bill) Heath	Microbiology and Immunology
Intraepithelial T cells in anti-viral immunity	Project Leader Professor Francis (Frank) Carbone	Microbiology and Immunology
Intravital imaging of T cell responses in the brain during cerebral malaria infection	Project Leader Professor William (Bill) Heath	Microbiology and Immunology
Keast & Osborne laboratory: Neural development, injury and pain	Joint Heads of Laboratory Professor Janet Keast & Dr Peregrine Osborne	Anatomy and Neuroscience
Lymphoid stromal cells and control of immunity to infection and cancer	Project Leader Associate Professor Scott Mueller	Microbiology and Immunology
Malaria and Tissue Resident Memory T cells (TRM) in the liver	Project Leader Professor William (Bill) Heath	Microbiology and Immunology
Malaria parasite-infected red blood cells: a renovator’s dream	Professor Leann Tilley	Biochemistry and Molecular Biology
Mueller laboratory: Visualising the immune system in action	Head of Laboratory Associate Professor Scott Mueller	Microbiology and Immunology
Mummy Studies	Dr Varsha Pilbrow	Anatomy and Neuroscience
Murray & Xiao laboratory: Neurotrophin and myelin	Joint Heads of Laboratory Dr Simon Murray & Dr Junhua Xiao	Anatomy and Neuroscience
Neural regulation of immunity	Project Leader Associate Professor Scott Mueller	Microbiology and Immunology
Parker Laboratory: Structural biology and computational drug design	Head of Laboratory and Director, Bio21 Institute Professor Michael Parker	Biochemistry and Molecular Biology
Pilbrow laboratory: Physical (biological) anthropology	Head of Laboratory Dr Varsha Pilbrow	Anatomy and Neuroscience
Priming of T cell responses to viral infection	Project Leader Associate Professor Scott Mueller	Microbiology and Immunology
Protein trafficking and cellular architecture	Professor Leann Tilley	Biochemistry and Molecular Biology
Rouiller laboratory: Understanding how molecular machines function through cryo-electron microscopy	Associate Professor Isabelle Rouiller	Biochemistry and Molecular Biology
Self-tolerance: Interactions between thymic stroma and dendritic cells	Project Leader Professor William (Bill) Heath	Microbiology and Immunology
Skeletal morphology	Dr Varsha Pilbrow	Anatomy and Neuroscience
Solving the native structure of the malaria parasite using cryo-electron microscopy	Professor Leann Tilley	Biochemistry and Molecular Biology
Stojanovski laboratory: Mitochondrial biogenesis in health and disease	Head of Laboratory Dr Diana Stojanovski	Biochemistry and Molecular Biology
T cell responses in the brain during experimental cerebral malaria infection	Project Leader Associate Professor Scott Mueller	Microbiology and Immunology
Taylor: Jack Brockhoff Reconstructive Plastic Surgery Research Unit	Head of Research Unit Professor Ian Taylor	Anatomy and Neuroscience
The role of glia in inner retinal changes during retinal degeneration	Head of Laboratory Professor Erica Fletcher	Anatomy and Neuroscience
The role of glial cells in retinal vascular disease	Head of Laboratory Professor Erica Fletcher	Anatomy and Neuroscience
The role of microglia in age-related macular degeneration	Head of Laboratory Professor Erica Fletcher	Anatomy and Neuroscience
Tilley laboratory: Measuring and modelling malaria parasites to develop new antimalarials	Head of Laboratory, ARC Australian Laureate Fellow Professor Leann Tilley	Biochemistry and Molecular Biology
Tissue-resident memory T cells	Project Leader Associate Professor Scott Mueller	Microbiology and Immunology
Understanding neuro-urothelial communication	Project Leader Professor Janet Keast	Anatomy and Neuroscience
Using biochemical approaches to investigating the trafficking and mechanism of action of the antiviral molecule, IFITM3	Project Leader Dr Linda Wakim	Microbiology and Immunology
Vaccination against liver-stage Plasmodium for malaria prevention	Project Leader Professor William (Bill) Heath	Microbiology and Immunology

Infection & Immunity

Groups / Projects	Research Lead	Dept / Centre
"Clock-off time" for inflammation and remodelling in chronic inflammatory diseases: casein kinase inhibitors	Primary Supervisor Professor Alastair Stewart	Pharmacology and Therapeutics
A cell-based model of sporadic prion disease	Associate Professor Vicki Lawson	Microbiology and Immunology
A new function of the cytokine BAFF in dendritic cell maturation: Implications for immunity and cancers	Senior Research Officer & Lab Manager Catherine Kennedy, PhD	Microbiology and Immunology
A novel link between metabolism and host defence: O-GlcNAc glycosylation	Professor Jose Villadangos	Biochemistry and Molecular Biology
A universal vaccine against influenza A	Project Leader Professor David Jackson	Microbiology and Immunology
Age-dependent susceptibility of neurons to RNA virus infection	Dr Lukasz Kedzierski	Microbiology and Immunology
Analysing protein structures	Dr David Ascher	Biochemistry and Molecular Biology
Antibody dependent cellular cytotoxicity - a neglected anti-HIV iImmune response!	Project Leaders Professor Stephen Kent & Dr Amy Chung	Microbiology and Immunology
Antimicrobial resistant bacterial pathogens	Project Leader Professor Ben Howden	Microbiology and Immunology
Application of genomics to public health and clinical microbiology	Project Leader Professor Ben Howden	Microbiology and Immunology
Application of systems genomics to analysing the dynamics of Streptococcus pyogenes infection	Dr Mark Davies	Microbiology and Immunology
Are there additional MAIT cell antigens?	Dr Sidonia Eckle	Microbiology and Immunology
Ascher laboratory: Structural biology and bioinformatics	Head of Laboratory Dr David Ascher	Biochemistry and Molecular Biology
Australian bite and sting trends: Australian Venomous Injury Project (AVIP)	Project Leader Dr Ronelle Welton	Pharmacology and Therapeutics
Australian Venom Research Unit	Head of Unit Dr David Williams	Pharmacology and Therapeutics
Autophagy and Norovirus replication	Professor Jason Mackenzie	Microbiology and Immunology
Biolpolymer-based vaccine delivery systems	Project Leader Professor David Jackson	Microbiology and Immunology
Blocking the development of secondary bacterial pneumonia	Dr Linda Wakim	Microbiology and Immunology
Bo&MeRanG Research Projects	Melbourne Coordinator Dr Marie Greyer
Bogoyevitch laboratory: Regulatory biology	Head of Laboratory Associate Professor Marie Bogoyevitch	Biochemistry and Molecular Biology
Brooks laboratory: Innate immunity; anti-viral immunity	Head of Laboratory Professor Andrew Brooks	Microbiology and Immunology
Brown laboratory: Immunology; virology; vaccinology	Head of Laboratory Professor Lorena (Lori) Brown	Microbiology and Immunology
Can resident memory B cells in the lung protect against respiratory syncytial virus?	Professor Stephen Kent	Microbiology and Immunology
Carbone laboratory: Immune response to herpes simplex virus	Head of Laboratory Professor Francis (Frank) Carbone	Microbiology and Immunology
CCVs: Clathrin-coated vesicles and Coxiella containing vacuoles	Dr Hayley Newton	Microbiology and Immunology
Cell surface receptors for attachment and entry of influenza virus into cells of the innate immune system	Project Leader Associate Professor Patrick Reading	Microbiology and Immunology
Characterisation of antimicrobial resistance and virulence of novel staphylococcal lineages	Associate Professor Steven Tong	Microbiology and Immunology
Characterisation of the changes of the endocytic and secretory pathway of dendritic cells upon activation	Associate Professor Isabelle Rouiller	Biochemistry and Molecular Biology
Characterising the cellular roles of metals	Research Project Leader Associate Professor Christopher McDevitt	Microbiology and Immunology
Chronic immune activation during treated HIV disease	Project Leader Professor Damian Purcell	Microbiology and Immunology
Correlates of severe and fatal influenza disease in high-risk groups	Head of Laboratory Associate Professor Katherine Kedzierska	Microbiology and Immunology
Crack laboratory: Neuropharmacology	Head of Laboratory Associate Professor Peter Crack	Pharmacology and Therapeutics
Deciphering the relative contributions of different dendritic cells to killer T cell responses	Project Leader Associate Professor Sammy Bedoui	Microbiology and Immunology
Decoding the trafficking of immune receptors	Dr Justine Mintern	Biochemistry and Molecular Biology
Defining the association between virulence and fitness of seasonal influenza viruses	Professor Kanta Subbarao	Microbiology and Immunology
Delineating how CD4 T cells ‘help’ establishing effective killer T cell responses	Project Leader Associate Professor Sammy Bedoui	Microbiology and Immunology
Dendritic cell maturation following different microbial stimulation	Project Leader Professor William (Bill) Heath	Microbiology and Immunology
Design and development of antibiotics against multidrug resistant bacteria	Project Leader Associate Professor Tony Velkov	Pharmacology and Therapeutics
Design of inhibitory drugs for molecular components of the siderophore biosynthetic pathway that are crucial for iron sequestration during mycobacterium tuberculosis (TB) pathogenesis	Project Leader Associate Professor Tony Velkov	Pharmacology and Therapeutics
Design, development and testing of HIV vaccines	Project Leader Professor Damian Purcell	Microbiology and Immunology
Designing better drugs	Dr David Ascher	Biochemistry and Molecular Biology
Designing new optogenetic tools for biomedical research	A/Prof Danny Hatters	Biochemistry and Molecular Biology
Determining the role of diet and microbiota in the progression of lupus	Professor Fabienne Mackay	Microbiology and Immunology
Developing a novel class of therapeutics for muscle wasting and frailty	Research Project Leader Dr Benjamin Parker	Physiology
Developing new therapies for Systemic Lupus Erythematosus	Senior Research Officer & Lab Manager Catherine Kennedy, PhD	Microbiology and Immunology
Development and application of soft culturing microenvironment for novel drug discovery	Professor Alastair Stewart	Pharmacology and Therapeutics
Development and application of soft culturing microenvironment for novel drug discovery	Primary Supervisor Professor Alastair Stewart	Pharmacology and Therapeutics
Development of a self-adjuvanting vaccine for enterotoxigenic Escherichia coli (ETEC)	Project Leader Professor David Jackson	Microbiology and Immunology
Development of new types of antimicrobial agents	Project Leader Professor Roy Robins-Browne	Microbiology and Immunology
Development of Novel antimalarial drugs	Professor Leann Tilley	Biochemistry and Molecular Biology
Development of novel proteomic tools to explore Burkholderia pathogenesis	Dr Nichollas Scott	Microbiology and Immunology
Diagnosis, treatment and prevention of medically relevant prion diseases	Associate Professor Vicki Lawson	Microbiology and Immunology
Discovering and characterizing new genes involved in innate immunity, tissue injury and fibrosis	Project Leader Professor Christine Wells	Anatomy and Neuroscience
Discovery of malaria vaccine peptide targets	Dr Daniel Fernandez-Ruiz	Microbiology and Immunology
Edgington-Mitchell laboratory: Protease Pathophysiology	Head of Research Group Dr Laura Edgington-Mitchell	Biochemistry and Molecular Biology
Enterococcus faecium	Project Leader Professor Ben Howden	Microbiology and Immunology
Evolution of streptococcal pathovars	Dr Mark Davies	Microbiology and Immunology
Evolutionary Genetics of avian influenza A viruses in Australia	Dr Michelle Wille	Microbiology and Immunology
Exploiting nanoparticles as vaccines	Dr Justine Mintern	Biochemistry and Molecular Biology
Finding clarity within a blizzard- guiding the solution of cryo-EM structures	Dr David Ascher	Biochemistry and Molecular Biology
Furness laboratory: Digestive physiology and nutrition	Head of Laboratory Professor John Furness	Anatomy and Neuroscience
Gamma delta T cells are important for malaria sporozoite vaccination	Dr Lynette Beattie	Microbiology and Immunology
Gleeson laboratory: Membrane trafficking and protein sorting in health and disease and development of new therapeutics	Head of Laboratory Professor Paul Gleeson	Biochemistry and Molecular Biology
Glucocorticoid responsiveness in the lung: impact of inflammation and infection	Professor Alastair Stewart	Pharmacology and Therapeutics
Glucocorticoid responsiveness in the lung: impact of inflammation and infection	Primary Supervisor Professor Alastair Stewart	Pharmacology and Therapeutics
Godfrey laboratory: The development and function of unconventional T cells	Head of Laboratory Professor Dale Godfrey	Microbiology and Immunology
Gooley laboratory: Structural biology of disease	Head of Laboratory Associate Professor Paul Gooley	Biochemistry and Molecular Biology
Gut health: an intersection of food, environment, animal production and global health	Project Supervisor Professor John B Furness	Anatomy and Neuroscience
Harnessing the molecular clock to activate diverse strains of latent HIV	Professor Sharon Lewin	Microbiology and Immunology
Harrap laboratory: Genetic physiology	Head of Laboratory Professor Stephen Harrap	Physiology
Heath laboratory: CD8 T lymphocytes, dendritic cells, self tolerance and immunity	Head of Laboratory Professor William (Bill) Heath	Microbiology and Immunology
High fat diets, gut health and diabetes	Project Leaders/Supervisors Dr Rachel McQuade & Professor John Furness	Anatomy and Neuroscience
How do tumours impact normal tissue functions?	Associate Professor Scott Mueller	Microbiology and Immunology
How does ageing effect antibody responses?	Dr Amy Chung	Microbiology and Immunology
How infection and trauma cause dendritic cell paralysis and lethal immunosuppression	Professor Jose Villadangos	Microbiology and Immunology
How is selective metal ion transport achieved at the host-pathogen interface?	Associate Professor Christopher McDevitt	Microbiology and Immunology
How is the immunological T cell memory generated?	Project Leader Associate Professor Katherine Kedzierska	Microbiology and Immunology
How to harness the immune system to cure cancer: adoptive cell immunotherapy	Professor Jose Villadangos	Microbiology and Immunology
Howden laboratory: Molecular epidemiology, genomics and pathogenesis of antimicrobial resistant bacteria	Head of Laboratory \| Director of MDU Professor Ben Howden	Microbiology and Immunology
Identification and characterisation of novel malarial transmission-blocking antigens	Associate Professor Siddhartha Mahanty	Microbiology and Immunology
Identifying novel subsets of immune cells that control cytomegalovirus following transplantation	Dr Lucy Sullivan	Microbiology and Immunology
Identifying the mechanisms of immune cell development in peripheral tissues	Project Leader Dr Laura Mackay	Microbiology and Immunology
Imaging effector and memory T cell responses in the skin following Herpes Simplex Virus-1 infection	Project Leader Professor William (Bill) Heath	Microbiology and Immunology
Imaging the priming of CD8 Killer T cell responses to Herpes Simplex Virus-1 skin infection	Project Leader Professor William (Bill) Heath	Microbiology and Immunology
Immuno-paralysis following severe infections or trauma	Professor Jose Villadangos	Microbiology and Immunology
Immunoregulatory functions of the MARCH family of ubiquitin ligases	Professor Jose Villadangos	Biochemistry and Molecular Biology
Immunoregulatory functions of the MARCH family of ubiquitin ligases	Professor Jose Villadangos	Microbiology and Immunology
Improved vaccines by targeting to dendritic cells	Project Leader Professor William (Bill) Heath	Microbiology and Immunology
Infection & Immunity
Infection induced changes to splenic macrophages	Dr Lynette Beattie	Microbiology and Immunology
Influenza A virus PB1-F2 Protein: a putative virulence factor and initiator of inflammation	Project Leader Dr Julie McAuley	Microbiology and Immunology
Influenza and HIV vaccines and the importance of mucosal immunity	Project Leader Professor Stephen Kent	Microbiology and Immunology
Influenza–specific ADCC: Role in a universal flu vaccine?	Project Leader Professor Stephen Kent	Microbiology and Immunology
Innate T cell recognition and development	Project Leader Dr Daniel Pellicci	Microbiology and Immunology
Innovative approaches to prepare synthetic, partially synthetic and natural product-based vaccines	Project Leader Professor David Jackson	Microbiology and Immunology
Integrative infectious disease phylodynamics	Dr Sebastian Duchene	Microbiology and Immunology
Intraepithelial T cells in anti-viral immunity	Project Leader Professor Francis (Frank) Carbone	Microbiology and Immunology
Intravital imaging of T cell responses in the brain during cerebral malaria infection	Project Leader Professor William (Bill) Heath	Microbiology and Immunology
Investigating the effect of hepatitis B virus splice variants in liver cells and disease progression	Professor Peter Revill	Microbiology and Immunology
Investigating the role of functional antibodies against Mycobacterium tuberculosis	Dr Amy Chung	Microbiology and Immunology
Investigation of HSV latency and reactivation	Project Leader Professor Francis (Frank) Carbone	Microbiology and Immunology
Jackson laboratory: Synthetic vaccine design	Head of Laboratory Professor David Jackson	Microbiology and Immunology
Kedzierska laboratory: Immunity to pandemic and newly emerged influenza viruses	Head of Laboratory Associate Professor Katherine Kedzierska	Microbiology and Immunology
Kent laboratory: HIV vaccines; immune responses to HIV-1; immunotherapy	Head of Laboratory Professor Stephen Kent	Microbiology and Immunology
Klebsiella pneumoniae	Project Leader Professor Dick Strugnell	Microbiology and Immunology
Koopman laboratory: Clinical nutrition and muscle metabolism	Head of Laboratory Dr René Koopman	Physiology
Lawson laboratory: Neurodegenerative disease caused by prions	Head of Laboratory Associate Professor Vicki Lawson	Microbiology and Immunology
Lew laboratory: Theoretical and empirical pharmacology	Head of Laboratory Dr Michael Lew	Pharmacology and Therapeutics
Lipopeptide-based adjuvanting systems	Project Leader Professor David Jackson	Microbiology and Immunology
Location, location, location – lodging virus specific T cells in the lung as an approach to protecting against influenza virus infection	Dr Linda Wakim	Microbiology and Immunology
Lung Disease Research Laboratory	Head of Laboratory Professor Gary P Anderson	Pharmacology and Therapeutics
Lung Health Research Centre		Pharmacology and Therapeutics
Lymphoid stromal cells and control of immunity to infection and cancer	Project Leader Associate Professor Scott Mueller	Microbiology and Immunology
Mackay (F) laboratory: B lymphocytes, BAFF, autoimmunity and cancer	Head of Laboratory Head of School of Biomedical Sciences Professor Fabienne Mackay	Microbiology and Immunology
Mackay (L) laboratory: Tissue-resident memory T cells; lymphocyte differentiation; peripheral immunity	Senior Lecturer & NHMRC Career Development Fellow, HHMI-Gates International Research Scholar Dr Laura Mackay	Microbiology and Immunology
Mackenzie laboratory: Intracellular virus replication and innate immunity	Head of Laboratory Professor Jason Mackenzie	Microbiology and Immunology
MAIT cells in homeostasis and microbial infections	Researchers Dr Zhenjun Chen, Dr Alexandra Corbett and Dr Sidonia Eckle	Microbiology and Immunology
Malaria and Tissue Resident Memory T cells (TRM) in the liver	Project Leader Professor William (Bill) Heath	Microbiology and Immunology
Malaria parasite-infected red blood cells: a renovator’s dream	Professor Leann Tilley	Biochemistry and Molecular Biology
Manipulating immunity to fight infection and tumours	Dr Justine Mintern	Biochemistry and Molecular Biology
Manipulating MAIT cells for increased protection by vaccination and therapy	Dr Alexandra Corbett	Microbiology and Immunology
Mapping elemental fluxes during host-pathogen interaction	Associate Professor Christopher McDevitt	Microbiology and Immunology
McConville laboratory: Molecular microbiology	Head of Laboratory Professor Malcolm McConville	Biochemistry and Molecular Biology
McDevitt laboratory	Head of Laboratory Associate Professor Christopher McDevitt	Microbiology and Immunology
Mechanisms underlying early generation of human T cell memory	Project Leader Associate Professor Katherine Kedzierska	Microbiology and Immunology
Memory T cell responses in the lung during virus infection	Project Leader Dr Linda Wakim	Microbiology and Immunology
Metal ion homeostasis in Klebsiella pneumoniae	Associate Professor Christopher McDevitt	Microbiology and Immunology
Mintern laboratory: Vaccine biology	Head of Laboratory Dr Justine Mintern	Biochemistry and Molecular Biology
Mitochondria and intracellular bacterial pathogens	Dr Hayley Newton	Microbiology and Immunology
Modulation of intestinal inflammation through nerve stimulation	Project Leader/Supervisor Dr Martin Stebbing	Anatomy and Neuroscience
Molecular basis for growth factor surveillance in natural killer cells	Dr Alexander David Barrow	Microbiology and Immunology
Molecular basis for growth factor surveillance in plasmacytoid dendritic cells	Dr Alexander David Barrow	Microbiology and Immunology
MR1 – a molecular alarm system for bacterial infection	Dr Hamish McWilliam	Microbiology and Immunology
MR1 – a molecular alarm system that detects pathogen metabolites	Professor Jose Villadangos	Microbiology and Immunology
Mueller laboratory: Visualising the immune system in action	Head of Laboratory Associate Professor Scott Mueller	Microbiology and Immunology
Munsie laboratory: Ethical, legal and social implications of stem cell research	Head of Laboratory Associate Professor Megan Munsie	Anatomy and Neuroscience
Mycobacterium ulcerans	Project Leader Professor TIm Stinear	Microbiology and Immunology
Nanoparticle Modulation of Mast Cell Function	Project Leader Dr Graham Mackay	Pharmacology and Therapeutics
Neural regulation of anti-cancer immunity	Associate Professor Scott Mueller	Microbiology and Immunology
Neural regulation of immunity	Project Leader Associate Professor Scott Mueller	Microbiology and Immunology
Neuro-immune interactions: Nerve pathways that control inflammation in the intestine	Project Leader/Supervisor Dr Martin Stebbing	Anatomy and Neuroscience
Neurodegeneration in the enteric nervous system	Associate Professor Vicki Lawson	Microbiology and Immunology
Newton laboratory: Virulence strategies of intracellular bacterial pathogens	Head of Laboratory Dr Hayley Newton	Microbiology and Immunology
NK cell receptor biology	Project Leader Professor Andrew Brooks	Microbiology and Immunology
Non-classical MHC and Class 1-like molecules	Project Leader Professor Andrew Brooks	Microbiology and Immunology
Non-conventional T cells and HIV: role of NKT cells, MAIT cells, CD-1 restricted and gamma-delta T cells	Project Leader Professor Stephen Kent	Microbiology and Immunology
Norovirus replication and innate immunity	Project Leader Professor Jason Mackenzie	Microbiology and Immunology
Novel Mast Cell-Derived Mediators	Project Leader Dr Graham Mackay	Pharmacology and Therapeutics
Novel master-regulators of B-cell biology	Professor Fabienne Mackay	Microbiology and Immunology
Nutrition: The control of gut hormone release by nutrients	Project Leader/Supervisor Professor John B Furness	Anatomy and Neuroscience
Parker Laboratory: Structural biology and computational drug design	Head of Laboratory and Director, Bio21 Institute Professor Michael Parker	Biochemistry and Molecular Biology
Passive antibody immunity for use in combination microbicides	Project Leader Professor Damian Purcell	Microbiology and Immunology
Pathogenesis of chronic lung disease	Head of Laboratory Dr Michelle Hansen	Pharmacology and Therapeutics
Pathogenesis of pneumococcal pneumonia	Associate Professor Catherine Satzke	Microbiology and Immunology
Plasma protein binding of antibiotics	Project Leader Associate Professor Tony Velkov	Pharmacology and Therapeutics
Population genomics of endemic Streptococcus pyogenes	Dr Mark Davies	Microbiology and Immunology
Preventing infections of the highly puke-ogenic virus - norovirus	Professor Jason Mackenzie	Microbiology and Immunology
Priming of T cell responses to viral infection	Project Leader Associate Professor Scott Mueller	Microbiology and Immunology
Programming gamma delta T cells for HIV immunotherapy	Professor Stephen Kent	Microbiology and Immunology
Protective capacity of malaria-specific liver-tissue-resident memory T cells	Dr Lauren Holz	Microbiology and Immunology
Protein trafficking and cellular architecture	Professor Leann Tilley	Biochemistry and Molecular Biology
Purcell laboratory: Viral RNA elements, regulation of HIV replication, HIV antibody vaccine	Head of Laboratory Professor Damian Purcell	Microbiology and Immunology
Quantifying bacterial recombination within globally evolving streptococcal pathogens	Dr Mark Davies	Microbiology and Immunology
Ralph laboratory: Drug targets and gene regulation in Plasmodium falciparum	Head of Laboratory Dr Stuart Ralph	Biochemistry and Molecular Biology
Rational Protein Engineering	Dr David Ascher	Biochemistry and Molecular Biology
Reading laboratory: Innate immune detection and response to respiratory virus infections	Head of Laboratory Associate Professor Patrick Reading	Microbiology and Immunology
Regeneration of lymphoid tissues	Associate Professor Scot Mueller	Microbiology and Immunology
Regulation of Mast Cell Activation	Project Leader Dr Graham Mackay	Pharmacology and Therapeutics
Restoring immunocompetency in Chronic Lymphocytic Leukemia	Senior Research Officer & Lab Manager Catherine Kennedy, PhD	Microbiology and Immunology
RNA mediated control of HIV-1 gene expression	Project Leader Professor Damian Purcell	Microbiology and Immunology
Robins-Browne laboratory: Medical bacteriology, pathogenesis, bacterial genetics, therapeutics	Head of Laboratory Professor Roy Robins-Browne	Microbiology and Immunology
Role of cellular lipids during Flavivirus replication	Project Leader Professor Jason Mackenzie	Microbiology and Immunology
Role of innate signals in inducing protective T cell immunity	Project Leader Associate Professor Sammy Bedoui	Microbiology and Immunology
Role of O-linked glycosylation system across the Burkholderia genus	Dr Nichollas Scott	Microbiology and Immunology
Role of suppressor of cytokine signalling proteins in viral encephalitis	Dr Lukasz Kedzierski	Microbiology and Immunology
Rouiller laboratory: Understanding how molecular machines function through cryo-electron microscopy	Associate Professor Isabelle Rouiller	Biochemistry and Molecular Biology
Rutar laboratory: Ocular Neuroimmunology	Head of Laboratory Dr Matt Rutar	Anatomy and Neuroscience
Salmonella Typhimurium	Project Leader Professor Dick Strugnell	Microbiology and Immunology
Self-tolerance: Interactions between thymic stroma and dendritic cells	Project Leader Professor William (Bill) Heath	Microbiology and Immunology
Sex in human malaria parasites	Dr Matthew Dixon	Biochemistry and Molecular Biology
Skeletal muscle signal transduction related to exercise, metabolic disease and human health	Research Project Leader Dr Benjamin Parker	Physiology
Small molecules for BIG targets- Targeting protein-protein interactions with fragments	Dr David Ascher	Biochemistry and Molecular Biology
SNAP - Staphylococcus aureus Network Adaptive Platform Trial	Associate Professor Steven Tong	Microbiology and Immunology
Soluble barriers to influenza virus infection	Project Leader Associate Professor Patrick Reading	Microbiology and Immunology
Solving the native structure of the malaria parasite using cryo-electron microscopy	Professor Leann Tilley	Biochemistry and Molecular Biology
Staphylococcus aureus & Enterococcus faecium	Project Leader Professor Tim Stinear	Microbiology and Immunology
Staphylococcus aureus and Staphylococcus epidermidis	Project Leader Professor Ben Howden	Microbiology and Immunology
Staphylococcus aureus bloodstream infections in Victorian hospitals: regional differences in disease burden and epidemiology	Associate Professor Leon Worth	Microbiology and Immunology
Stewart Laboratory: Mechanopharmacology	Head of Laboratory Professor Alastair Stewart	Pharmacology and Therapeutics
Stinear laboratory: Bacterial pathogenomics	Head of Laboratory Professor Tim Stinear	Microbiology and Immunology
Streptococcal transmission and disease	Associate Professor Catherine Satzke	Microbiology and Immunology
Structural Biology of Infection	Professor Michael Parker	Biochemistry and Molecular Biology
Strugnell laboratory: Bacterial pathogenesis and host responses	Head of Laboratory Professor Dick Strugnell	Microbiology and Immunology
Synergistic and antagonistic interplay between Streptococcus pneumoniae and respiratory viruses	Associate Professor Catherine Satzke	Microbiology and Immunology
Systems genetics of muscle metabolism	Research Project Leader Dr Benjamin Parker	Physiology
T cell responses in the brain during experimental cerebral malaria infection	Project Leader Associate Professor Scott Mueller	Microbiology and Immunology
T cells in peripheral immunity	Project Leader Professor Francis (Frank) Carbone	Microbiology and Immunology
Tackling drug resistance	Dr David Ascher	Biochemistry and Molecular Biology
Testing a novel strategy to target chronic lymphocytic leukemia	Professor Fabienne Mackay	Microbiology and Immunology
The Cardiovascular Pharmacology of Snake Venoms From Papua New Guinea and Australia	Project Leader Associate Professor Christine Wright	Pharmacology and Therapeutics
The importance of IgA in the protection and control of infectious diseases	Dr Amy Chung	Microbiology and Immunology
The innate immune system in the respiratory tract	Project Leader Professor David Jackson	Microbiology and Immunology
The mechanisms of viral escape in murine and human influenza infection	Project Leader Associate Professor Katherine Kedzierska	Microbiology and Immunology
The role of CD4+ T cells in viral infections	Project Leader Professor Andrew Brooks	Microbiology and Immunology
The role of co-pathologies in the clinical presentation of prion disease	Associate Professor Vicki Lawson	Microbiology and Immunology
The Role of CXCR7 in Tissue Fibrosis	Senior Research Officer & Lab Manager Catherine Kennedy, PhD	Microbiology and Immunology
The role of glucose metabolism in the regulation of immunity	Professor Jose Villadangos	Microbiology and Immunology
The role of innate immune cells in protection and pathology during influenza virus infection	Project Leader Associate Professor Patrick Reading	Microbiology and Immunology
The role of protein modifications on muscle development	Research Project Leader Dr Benjamin Parker	Physiology
The role of resident memory T cells in barrier immunity and autoimmune disease	Project Leader Dr Laura Mackay	Microbiology and Immunology
The role of the prion protein in brain cancer	Associate Professor Vicki Lawson	Microbiology and Immunology
The roles of metal ions in host-pathogen interaction	Research Project Leader Associate Professor Christopher McDevitt	Microbiology and Immunology
The space of evolutionary trees in infectious disease epidemiology	Dr Sebastian Duchene	Microbiology and Immunology
The Treatment of Papuan Taipan Envenoming in Papua New Guinea	Project Leader Dr David Williams	Pharmacology and Therapeutics
Tilley laboratory: Measuring and modelling malaria parasites to develop new antimalarials	Head of Laboratory, ARC Australian Laureate Fellow Professor Leann Tilley	Biochemistry and Molecular Biology
Tissue-resident memory T cells	Project Leader Associate Professor Scott Mueller	Microbiology and Immunology
Tracking phenotypically and functionally distinct T cell subsets via T cell repertoire diversity	Project Leader Associate Professor Katherine Kedzierska	Microbiology and Immunology
Uncovering the interplay between innate immunity and the blood brain barrier in disorders of the CNS	Project Leader Professor Christine Wells	Anatomy and Neuroscience
Understanding how Anthrax toxins function	Associate Professor Isabelle Rouiller	Biochemistry and Molecular Biology
Understanding how metal ions traverse bacterial cell membranes	Research Project Leader Associate Professor Christopher McDevitt	Microbiology and Immunology
Understanding immune dysfunction in acute myeloid leukemia	Dr Justine Mintern	Biochemistry and Molecular Biology
Understanding the biological chemistry of pneumococcal disease	Associate Professor Christopher McDevitt	Microbiology and Immunology
Understanding the immune microenvironment in brain tumours	Dr Theo Mantamadiotis	Microbiology and Immunology
Understanding the importance of variation in the capsular polysaccharide of Streptococcus pneumoniae	Associate Professor Catherine Satzke	Microbiology and Immunology
Understanding the interaction between microbiota and T cell immunity	Project Leader Associate Professor Sammy Bedoui	Microbiology and Immunology
Understanding the mechanisms that impair anti-tumour adoptive cell therapy	Professor Jose Villadangos	Microbiology and Immunology
Understanding the Molecular Consequences of Mutations	Dr David Ascher David Ascher	Biochemistry and Molecular Biology
Understanding the regulation of tissue-resident memory T cell development	Project Leader Dr Laura Mackay	Microbiology and Immunology
Understanding the role of MAIT cells in immune-mediated pathology	Dr Sidonia Eckle	Microbiology and Immunology
Understanding the role of MAIT cells in protection from microbial infections	Dr Sidonia Eckle	Microbiology and Immunology
Understanding ‘universal’ influenza-specific CD8+ T cell responses	Project Leader Associate Professor Katherine Kedzierska	Microbiology and Immunology
Unravelling the drivers of scarlet fever pandemics	Dr Mark Davies	Microbiology and Immunology
Using biochemical approaches to investigating the trafficking and mechanism of action of the antiviral molecule, IFITM3	Project Leader Dr Linda Wakim	Microbiology and Immunology
Using genomics to investigate the transmission of skin pathogens and antimicrobial resistance in a ‘One Health’ setting	Dr Mark Davies	Microbiology and Immunology
Using the immune system to kill tumours	Dr Justine Mintern	Biochemistry and Molecular Biology
Using transcriptional analyses to understand recognition of tumours by natural killer cells	Professor Andrew Brooks	Microbiology and Immunology
Vaccination against liver-stage Plasmodium for malaria prevention	Project Leader Professor William (Bill) Heath	Microbiology and Immunology
Validating human transgenic mouse models for lupus therapeutics development	Professor Fabienne Mackay	Microbiology and Immunology
van Driel laboratory: Immune responses to pathogens	Head of Laboratory Professor Ian van Driel	Biochemistry and Molecular Biology
Velkov laboratory: Antiinfective pharmacology	Head of Laboratory Associate Professor Tony Velkov	Pharmacology and Therapeutics
Vertical transmission of Ross River virus in mosquito vectors	Dr Julio Rodriguez-Andres	Microbiology and Immunology
Villadangos laboratory: Antigen presenting cells & molecules that initiate T cell immunity against pathogens and cancer	Head of Laboratory Professor Jose Villadangos	Microbiology and Immunology
Viral interactions with the innate immune system	Project Leader Associate Professor Patrick Reading	Microbiology and Immunology
Visualization and formation West Nile Virus replication complexes	Project Leader Professor Jason Mackenzie	Microbiology and Immunology
Wells laboratory: Stem cell systems	Head of Laboratory Professor Christine Wells	Anatomy and Neuroscience
West Nile Virus replication and cellular stress responses	Project Leader Professor Jason Mackenzie	Microbiology and Immunology
What do antibodies need to do to protect a woman against pregnancy-malaria?	Dr Elizabeth Aitken	Microbiology and Immunology
Whole body analysis of human tissue-resident memory T cells	Dr Claire Gordon	Microbiology and Immunology
Why is the flavivirus RdRp in the nucleus?	Professor Jason Mackenzie	Microbiology and Immunology
Wilkinson-Berka laboratory: Retinal vascular biology and inflammation	Head of Laboratory Professor Jennifer Wilkinson-Berka	Anatomy and Neuroscience
Williamson laboratory: Public health, AMR, epidemiology and microbiology	Head of Laboratory Associate Professor Deborah Williamson	Microbiology and Immunology
“Clock-off time” for inflammation and remodelling in chronic inflammatory diseases: casein kinase inhibitors	Professor Alastair Stewart	Pharmacology and Therapeutics

252

Molecular Mechanisms of Disease

Groups / Projects	Research Lead	Dept / Centre
"Clock-off time" for inflammation and remodelling in chronic inflammatory diseases: casein kinase inhibitors	Primary Supervisor Professor Alastair Stewart	Pharmacology and Therapeutics
A novel link between metabolism and host defence: O-GlcNAc glycosylation	Professor Jose Villadangos	Biochemistry and Molecular Biology
A universal vaccine against influenza A	Project Leader Professor David Jackson	Microbiology and Immunology
Analysing protein structures	Dr David Ascher	Biochemistry and Molecular Biology
Angiotensin and chemoreceptor function	Research Project Leader Professor Andrew Allen	Physiology
Antibody dependent cellular cytotoxicity - a neglected anti-HIV iImmune response!	Project Leaders Professor Stephen Kent & Dr Amy Chung	Microbiology and Immunology
Antimicrobial resistant bacterial pathogens	Project Leader Professor Ben Howden	Microbiology and Immunology
Application of genomics to public health and clinical microbiology	Project Leader Professor Ben Howden	Microbiology and Immunology
Applications of Nanopore sequencing	Project Leader Dr Mike Clark	Anatomy and Neuroscience
Ascher laboratory: Structural biology and bioinformatics	Head of Laboratory Dr David Ascher	Biochemistry and Molecular Biology
Autophagy and Norovirus replication	Professor Jason Mackenzie	Microbiology and Immunology
Biolpolymer-based vaccine delivery systems	Project Leader Professor David Jackson	Microbiology and Immunology
Bo&MeRanG Research Projects	Melbourne Coordinator Dr Marie Greyer
Bogoyevitch laboratory: Regulatory biology	Head of Laboratory Associate Professor Marie Bogoyevitch	Biochemistry and Molecular Biology
Bornstein laboratory: Enteric neuroscience	Head of Laboratory Professor Joel C Bornstein	Physiology
Brain networks processing respiratory sensations	Project Leader Associate Professor Stuart Mazzone	Anatomy and Neuroscience
Brooks laboratory: Innate immunity; anti-viral immunity	Head of Laboratory Professor Andrew Brooks	Microbiology and Immunology
Brown laboratory: Immunology; virology; vaccinology	Head of Laboratory Professor Lorena (Lori) Brown	Microbiology and Immunology
Can drug-like mimetics of BDNF promote remyelination after injury?	Dr Junhua Xiao	Anatomy and Neuroscience
Cappai laboratory: Neurodegeneration and Brain Injury	Head of Laboratory Professor Roberto Cappai	Pharmacology and Therapeutics
Carbone laboratory: Immune response to herpes simplex virus	Head of Laboratory Professor Francis (Frank) Carbone	Microbiology and Immunology
Cell surface receptors for attachment and entry of influenza virus into cells of the innate immune system	Project Leader Associate Professor Patrick Reading	Microbiology and Immunology
Characterising the cellular roles of metals	Research Project Leader Associate Professor Christopher McDevitt	Microbiology and Immunology
Characterising the pathways responsible for ICU-acquired weakness	Research Project Leader Dr René Koopman	Physiology
Cheng laboratory: Molecular enzymology of protein kinases and phosphatases involved in human diseases	Head of Laboratory Associate Professor Heung-Chin Cheng	Biochemistry and Molecular Biology
Chronic immune activation during treated HIV disease	Project Leader Professor Damian Purcell	Microbiology and Immunology
Clark laboratory: Transcriptomics and Neurogenetics	Head of Laboratory Dr Mike Clark	Anatomy and Neuroscience
Correlates of severe and fatal influenza disease in high-risk groups	Head of Laboratory Associate Professor Katherine Kedzierska	Microbiology and Immunology
Crack laboratory: Neuropharmacology	Head of Laboratory Associate Professor Peter Crack	Pharmacology and Therapeutics
Crouch laboratory: Neurodegenerative disease	Head of Laboratory Dr Peter Crouch	Pharmacology and Therapeutics
de Iongh laboratory: Ocular development laboratory	Head of Laboratory Associate Professor Robb de Iongh	Anatomy and Neuroscience
Deciphering the relative contributions of different dendritic cells to killer T cell responses	Project Leader Associate Professor Sammy Bedoui	Microbiology and Immunology
Decoding the trafficking of immune receptors	Dr Justine Mintern	Biochemistry and Molecular Biology
Defining new roles for the Hippo signalling pathway in skeletal muscle	Research Project Leader Associate Professor Paul Gregorevic	Physiology
Delineating how CD4 T cells ‘help’ establishing effective killer T cell responses	Project Leader Associate Professor Sammy Bedoui	Microbiology and Immunology
Dendritic cell maturation following different microbial stimulation	Project Leader Professor William (Bill) Heath	Microbiology and Immunology
Design, development and testing of HIV vaccines	Project Leader Professor Damian Purcell	Microbiology and Immunology
Developing a novel class of therapeutics for muscle wasting and frailty	Research Project Leader Dr Benjamin Parker	Physiology
Developing innovative animal and cell culture models to study and treat muscular dystrophies	Research Project Leader Associate Professor Paul Gregorevic	Physiology
Developing new therapies for Systemic Lupus Erythematosus	Senior Research Officer & Lab Manager Catherine Kennedy, PhD	Microbiology and Immunology
Development of a self-adjuvanting vaccine for enterotoxigenic Escherichia coli (ETEC)	Project Leader Professor David Jackson	Microbiology and Immunology
Development of autonomic and nociceptive circuits	Project Leader Professor Janet Keast	Anatomy and Neuroscience
Development of new types of antimicrobial agents	Project Leader Professor Roy Robins-Browne	Microbiology and Immunology
Discovering and characterizing new genes involved in innate immunity, tissue injury and fibrosis	Project Leader Professor Christine Wells	Anatomy and Neuroscience
Towards understanding new therapies for obesity and diabetes: discovering new regulators of lipid metabolism	Research Project Leader Professor Matthew Watt	Physiology
Dodd laboratory: Metabolic Neuroscience	Head of Laboratory Dr Garron Dodd	Physiology
Edgington-Mitchell laboratory: Protease Pathophysiology	Head of Research Group Dr Laura Edgington-Mitchell	Biochemistry and Molecular Biology
EMT regulators in intestinal and germline stem cells	Project Leader Professor Gary Hime	Anatomy and Neuroscience
Enterococcus faecium	Project Leader Professor Ben Howden	Microbiology and Immunology
Establishing the effect of glycine/serine metabolism on skeletal muscle cell growth	Research Project Leader Dr René Koopman	Physiology
Exercise-induced liver-muscle cross-talk and mitochondrial adaptations	Research Project Leader Dr Magdalene Montgomery	Physiology
Exploiting nanoparticles as vaccines	Dr Justine Mintern	Biochemistry and Molecular Biology
Exploring new roles for the TGFβ signalling network as a key regulator of skeletal muscle in health and disease	Research Project Leader Associate Professor Paul Gregorevic	Physiology
Factors that accelerate photoreceptor death: The role of purines	Head of Laboratory Professor Erica Fletcher	Anatomy and Neuroscience
Fletcher laboratory: Visual neuroscience	Head of Laboratory Professor Erica Fletcher	Anatomy and Neuroscience
Furness laboratory: Digestive physiology and nutrition	Head of Laboratory Professor John Furness	Anatomy and Neuroscience
Gleeson laboratory: Membrane trafficking and protein sorting in health and disease and development of new therapeutics	Head of Laboratory Professor Paul Gleeson	Biochemistry and Molecular Biology
Glial cells as a source of progenitor cells in degenerative disease	Head of Laboratory Professor Erica Fletcher	Anatomy and Neuroscience
Godfrey laboratory: The development and function of unconventional T cells	Head of Laboratory Professor Dale Godfrey	Microbiology and Immunology
Gooley laboratory: Structural biology of disease	Head of Laboratory Associate Professor Paul Gooley	Biochemistry and Molecular Biology
Gregorevic laboratory: Muscle Research and Therapeutics	Head of Laboratory Associate Professor Paul Gregorevic	Physiology
Griffin laboratory: Functional and mis-functional protein-protein interactions	Head of Laboratory Dr Michael Griffin	Biochemistry and Molecular Biology
Gunnersen laboratory: Neuron development and plasticity	Head of Laboratory Dr Jenny Gunnersen	Anatomy and Neuroscience
Hatters laboratory: Protein misfolding and proteostasis in neurodegenerative diseases	Head of Laboratory Associate Professor Danny Hatters	Biochemistry and Molecular Biology
Heath laboratory: CD8 T lymphocytes, dendritic cells, self tolerance and immunity	Head of Laboratory Professor William (Bill) Heath	Microbiology and Immunology
Hime laboratory: Stem cell genetics and Drosophila models of human disease	Head of Laboratory Professor Gary Hime	Anatomy and Neuroscience
Hinde laboratory: Biophysics of Nuclear Organisation	Head of Research Group Dr Elizabeth Hinde	Biochemistry and Molecular Biology
How does GM-CSF prevent brain damage after traumatic injury?	Head of Laboratory Dr Jenny Gunnersen Project Leader Dr Sandy Shultz	Anatomy and Neuroscience
How early life experience influences brain myelination and function late in life?	Dr Junhua Xiao	Anatomy and Neuroscience
How infection and trauma cause dendritic cell paralysis and lethal immunosuppression	Professor Jose Villadangos	Microbiology and Immunology
How is the immunological T cell memory generated?	Project Leader Associate Professor Katherine Kedzierska	Microbiology and Immunology
Howden laboratory: Molecular epidemiology, genomics and pathogenesis of antimicrobial resistant bacteria	Head of Laboratory \| Director of MDU Professor Ben Howden	Microbiology and Immunology
Hoyer laboratory: Translational neuroscience	Head of Laboratory Head of Department Deputy Head, School of Biomedical Sciences Professor Daniel Hoyer	Pharmacology and Therapeutics
Human brain networks processing respiratory sensations	Project Leader Associate Professor Stuart Mazzone	Anatomy and Neuroscience
Hypothalamic modulation of basal sympathetic activity	Research Project Leader Professor Andrew Allen	Physiology
Identifying factors that improve gastrointestinal function in Duchenne's muscular dystrophy	Research Project Leader Professor Gordon Lynch	Physiology
Identifying the mechanisms of immune cell development in peripheral tissues	Project Leader Dr Laura Mackay	Microbiology and Immunology
Imaging effector and memory T cell responses in the skin following Herpes Simplex Virus-1 infection	Project Leader Professor William (Bill) Heath	Microbiology and Immunology
Imaging the priming of CD8 Killer T cell responses to Herpes Simplex Virus-1 skin infection	Project Leader Professor William (Bill) Heath	Microbiology and Immunology
Immunoregulatory functions of the MARCH family of ubiquitin ligases	Professor Jose Villadangos	Biochemistry and Molecular Biology
Improved vaccines by targeting to dendritic cells	Project Leader Professor William (Bill) Heath	Microbiology and Immunology
Improving recovery of injured visceral nerves and their spinal control centres	Project Leader Professor Janet Keast	Anatomy and Neuroscience
Improving the diagnostic outcomes of patients with mitochondrial disease	Dr David Stroud	Biochemistry and Molecular Biology
Influenza A virus PB1-F2 Protein: a putative virulence factor and initiator of inflammation	Project Leader Dr Julie McAuley	Microbiology and Immunology
Influenza and HIV vaccines and the importance of mucosal immunity	Project Leader Professor Stephen Kent	Microbiology and Immunology
Influenza–specific ADCC: Role in a universal flu vaccine?	Project Leader Professor Stephen Kent	Microbiology and Immunology
Innate immunity and neural injury	Head of Laboratory Associate Professor Peter Crack	Pharmacology and Therapeutics
Innate T cell recognition and development	Project Leader Dr Daniel Pellicci	Microbiology and Immunology
Innovative approaches to prepare synthetic, partially synthetic and natural product-based vaccines	Project Leader Professor David Jackson	Microbiology and Immunology
Insulin on the Brain	Research Project Leader Dr Garron Dodd	Physiology
Interplay of sex differentiation and metabolism	Project Leader Associate Professor Dagmar Wilhelm	Anatomy and Neuroscience
Intraepithelial T cells in anti-viral immunity	Project Leader Professor Francis (Frank) Carbone	Microbiology and Immunology
Intravital imaging of T cell responses in the brain during cerebral malaria infection	Project Leader Professor William (Bill) Heath	Microbiology and Immunology
Investigating mechanisms of protein trafficking to human mitochondria	Dr Diana Stojanovski	Biochemistry and Molecular Biology
Investigating the Dystrophin-Glycoprotein Complex to Protect Muscles from Wasting Conditions	Research Project Leader Professor Gordon Lynch	Physiology
Investigating the molecular basis of central myelination and repair	Dr Junhua Xiao	Anatomy and Neuroscience
Investigating the role of cachexia in the response to surgical tumour resection in mice	Research Project Leader Professor Gordon Lynch	Physiology
Investigation of HSV latency and reactivation	Project Leader Professor Francis (Frank) Carbone	Microbiology and Immunology
Is the “shed” form of Sez-6 proteins responsible for their synapse-promoting effects?	Head of Laboratory Dr Jenny Gunnersen Project Leader Dr Kathryn Munro	Anatomy and Neuroscience
Ivanusic laboratory: Pain and sensory mechanisms	Head of Laboratory Associate Professor Jason Ivanusic	Anatomy and Neuroscience
Jackson laboratory: Synthetic vaccine design	Head of Laboratory Professor David Jackson	Microbiology and Immunology
Keast & Osborne laboratory: Neural development, injury and pain	Joint Heads of Laboratory Professor Janet Keast & Dr Peregrine Osborne	Anatomy and Neuroscience
Kedzierska laboratory: Immunity to pandemic and newly emerged influenza viruses	Head of Laboratory Associate Professor Katherine Kedzierska	Microbiology and Immunology
Kent laboratory: HIV vaccines; immune responses to HIV-1; immunotherapy	Head of Laboratory Professor Stephen Kent	Microbiology and Immunology
Kilpatrick laboratory: Neuroimmunology of Multiple Sclerosis	Head of Laboratory Professor Trevor Kilpatrick	Anatomy and Neuroscience
Klebsiella pneumoniae	Project Leader Professor Dick Strugnell	Microbiology and Immunology
Koopman laboratory: Clinical nutrition and muscle metabolism	Head of Laboratory Dr René Koopman	Physiology
Lawson laboratory: Neurodegenerative disease caused by prions	Head of Laboratory Associate Professor Vicki Lawson	Microbiology and Immunology
Learning from skeletal muscles to develop new treatments for cancer	Research Project Leader Associate Professor Paul Gregorevic	Physiology
Lipopeptide-based adjuvanting systems	Project Leader Professor David Jackson	Microbiology and Immunology
Lung Disease Research Laboratory	Head of Laboratory Professor Gary P Anderson	Pharmacology and Therapeutics
Lynch laboratory: Basic and clinical myology	Head of Laboratory Professor Gordon Lynch	Physiology
Mackay (F) laboratory: B lymphocytes, BAFF, autoimmunity and cancer	Head of Laboratory Head of School of Biomedical Sciences Professor Fabienne Mackay	Microbiology and Immunology
Mackay (L) laboratory: Tissue-resident memory T cells; lymphocyte differentiation; peripheral immunity	Senior Lecturer & NHMRC Career Development Fellow, HHMI-Gates International Research Scholar Dr Laura Mackay	Microbiology and Immunology
Mackenzie laboratory: Intracellular virus replication and innate immunity	Head of Laboratory Professor Jason Mackenzie	Microbiology and Immunology
MAIT cells in homeostasis and microbial infections	Researchers Dr Zhenjun Chen, Dr Alexandra Corbett and Dr Sidonia Eckle	Microbiology and Immunology
Malaria and Tissue Resident Memory T cells (TRM) in the liver	Project Leader Professor William (Bill) Heath	Microbiology and Immunology
Manipulating immunity to fight infection and tumours	Dr Justine Mintern	Biochemistry and Molecular Biology
Mapping the distribution of angiotensin receptors in the brain	Research Project Leader Professor Andrew Allen	Physiology
Mapping the proteome vulnerable to unfolding and aggregation under proteostasis stress	A/Prof Danny Hatters	Biochemistry and Molecular Biology
Mature and developing synaptic transmission between defined classes of enteric neurons	Research Project Leader Dr Jaime Foong	Physiology
Mazzone laboratory: Respiratory Sensory Neuroscience	Head of Research Group Associate Professor Stuart Mazzone	Anatomy and Neuroscience
McConville laboratory: Molecular microbiology	Head of Laboratory Professor Malcolm McConville	Biochemistry and Molecular Biology
McDevitt laboratory	Head of Laboratory Associate Professor Christopher McDevitt	Microbiology and Immunology
Mechanisms underlying early generation of human T cell memory	Project Leader Associate Professor Katherine Kedzierska	Microbiology and Immunology
Memory T cell responses in the lung during virus infection	Project Leader Dr Linda Wakim	Microbiology and Immunology
Metabolic reprogramming of skeletal muscle stem cells	Research Project Leader Professor Gordon Lynch	Physiology
Mintern laboratory: Vaccine biology	Head of Laboratory Dr Justine Mintern	Biochemistry and Molecular Biology
Modelling sensory neuron-epithelial interactions	Project Leader Associate Professor Stuart Mazzone	Anatomy and Neuroscience
Molecular and cellular analysis of mammalian ovary development and disease	Project Leader Associate Professor Dagmar Wilhelm	Anatomy and Neuroscience
Molecular Mechanisms of Disease
Molecular mechanisms that contribute to skeletal pain	Head of Laboratory Associate Professor Jason Ivanusic	Anatomy and Neuroscience
Montgomery laboratory: Metabolic Tissue Cross-Talk	Head of Laboratory Dr Magdalene Montgomery	Physiology
MR1 – a molecular alarm system that detects pathogen metabolites	Professor Jose Villadangos	Microbiology and Immunology
Murray & Xiao laboratory: Neurotrophin and myelin	Joint Heads of Laboratory Dr Simon Murray & Dr Junhua Xiao	Anatomy and Neuroscience
Mycobacterium ulcerans	Project Leader Professor TIm Stinear	Microbiology and Immunology
Nanoparticle Modulation of Mast Cell Function	Project Leader Dr Graham Mackay	Pharmacology and Therapeutics
Newton laboratory: Virulence strategies of intracellular bacterial pathogens	Head of Laboratory Dr Hayley Newton	Microbiology and Immunology
NK cell receptor biology	Project Leader Professor Andrew Brooks	Microbiology and Immunology
Non-classical MHC and Class 1-like molecules	Project Leader Professor Andrew Brooks	Microbiology and Immunology
Non-conventional T cells and HIV: role of NKT cells, MAIT cells, CD-1 restricted and gamma-delta T cells	Project Leader Professor Stephen Kent	Microbiology and Immunology
Norovirus replication and innate immunity	Project Leader Professor Jason Mackenzie	Microbiology and Immunology
Novel Mast Cell-Derived Mediators	Project Leader Dr Graham Mackay	Pharmacology and Therapeutics
Oxidative stress and neural injury	Head of Laboratory Associate Professor Peter Crack	Pharmacology and Therapeutics
Pain management using ultrasound-guided local anaesthetic techniques	Head of Laboratory Associate Professor Jason Ivanusic	Anatomy and Neuroscience
Parker laboratory: Metabolic Proteomics & Signal Transduction	Head of Laboratory Dr Benjamin Parker	Physiology
Parker Laboratory: Structural biology and computational drug design	Head of Laboratory and Director, Bio21 Institute Professor Michael Parker	Biochemistry and Molecular Biology
Passive antibody immunity for use in combination microbicides	Project Leader Professor Damian Purcell	Microbiology and Immunology
Personalising treatments for genetic diseases	Dr David Ascher	Biochemistry and Molecular Biology
Post-translational control of cell fate decisions	Project Leader Associate Professor Dagmar Wilhelm	Anatomy and Neuroscience
Principles of Peripheral Nerve Myelination	Dr Simon Murray	Anatomy and Neuroscience
Prognostic biomarker and therapeutic target discovery in stroke	Project Leader Dr Jonathon Mangum	Pharmacology and Therapeutics
Purcell laboratory: Viral RNA elements, regulation of HIV replication, HIV antibody vaccine	Head of Laboratory Professor Damian Purcell	Microbiology and Immunology
Ralph laboratory: Drug targets and gene regulation in Plasmodium falciparum	Head of Laboratory Dr Stuart Ralph	Biochemistry and Molecular Biology
Reading laboratory: Innate immune detection and response to respiratory virus infections	Head of Laboratory Associate Professor Patrick Reading	Microbiology and Immunology
Regulation of Mast Cell Activation	Project Leader Dr Graham Mackay	Pharmacology and Therapeutics
Reid laboratory: Proteomics and lipidomics in health and disease	Head of Laboratory Professor Gavin E. Reid	Biochemistry and Molecular Biology
Restoring immunocompetency in Chronic Lymphocytic Leukemia	Senior Research Officer & Lab Manager Catherine Kennedy, PhD	Microbiology and Immunology
Risk genes for neuropsychiatric disorders	Project Leader Dr Mike Clark	Anatomy and Neuroscience
RNA mediated control of HIV-1 gene expression	Project Leader Professor Damian Purcell	Microbiology and Immunology
Robins-Browne laboratory: Medical bacteriology, pathogenesis, bacterial genetics, therapeutics	Head of Laboratory Professor Roy Robins-Browne	Microbiology and Immunology
Role of cellular lipids during Flavivirus replication	Project Leader Professor Jason Mackenzie	Microbiology and Immunology
Role of innate signals in inducing protective T cell immunity	Project Leader Associate Professor Sammy Bedoui	Microbiology and Immunology
Role of long noncoding RNAs in neurological disorders	Project Leader Dr Mike Clark	Anatomy and Neuroscience
Salmonella Typhimurium	Project Leader Professor Dick Strugnell	Microbiology and Immunology
Saunders laboratory: Developmental neuroscience and neurotrauma	Head of Laboratory Professor Norman Saunders	Pharmacology and Therapeutics
Self-tolerance: Interactions between thymic stroma and dendritic cells	Project Leader Professor William (Bill) Heath	Microbiology and Immunology
Sex in human malaria parasites	Dr Matthew Dixon	Biochemistry and Molecular Biology
Skeletal muscle signal transduction related to exercise, metabolic disease and human health	Research Project Leader Dr Benjamin Parker	Physiology
Small molecules for BIG targets- Targeting protein-protein interactions with fragments	Dr David Ascher	Biochemistry and Molecular Biology
Smith laboratory: Cardiac Form and Function	Head of Laboratory Associate Professor Kelly Smith	Physiology
Soluble barriers to influenza virus infection	Project Leader Associate Professor Patrick Reading	Microbiology and Immunology
Staphylococcus aureus & Enterococcus faecium	Project Leader Professor Tim Stinear	Microbiology and Immunology
Staphylococcus aureus and Staphylococcus epidermidis	Project Leader Professor Ben Howden	Microbiology and Immunology
Stojanovski laboratory: Mitochondrial biogenesis in health and disease	Head of Laboratory Dr Diana Stojanovski	Biochemistry and Molecular Biology
Stroke	Head of Laboratory Associate Professor Peter Crack	Pharmacology and Therapeutics
Stroud laboratory: Mitochondrial Systems Biology	Head of Research Group Dr David Stroud	Biochemistry and Molecular Biology
Structural Biology of Cancer	Professor Michael Parker	Biochemistry and Molecular Biology
Structural Biology of Infection	Professor Michael Parker	Biochemistry and Molecular Biology
Structural Neurobiology	Professor Michael Parker	Biochemistry and Molecular Biology
Strugnell laboratory: Bacterial pathogenesis and host responses	Head of Laboratory Professor Dick Strugnell	Microbiology and Immunology
Systems genetics of muscle metabolism	Research Project Leader Dr Benjamin Parker	Physiology
T cells in peripheral immunity	Project Leader Professor Francis (Frank) Carbone	Microbiology and Immunology
Tackling drug resistance	Dr David Ascher	Biochemistry and Molecular Biology
The amyloidogenic protease inhibitor Cystatin C in health and disease	Prof. Jose Villadangos	Biochemistry and Molecular Biology
The Enteric Neural Circuitry Activated During Bacterial-toxin Induced Diarrhoea	Research Project Leader Dr Jaime Foong	Physiology
The GDNF family, peripheral nerve regeneration and pain	Project Leader Professor Janet Keast	Anatomy and Neuroscience
The heart as a central player in tissue cross-talk	Research Project Leader Dr Magdalene Montgomery	Physiology
The innate immune system in the respiratory tract	Project Leader Professor David Jackson	Microbiology and Immunology
The mechanisms of viral escape in murine and human influenza infection	Project Leader Associate Professor Katherine Kedzierska	Microbiology and Immunology
The role of CD4+ T cells in viral infections	Project Leader Professor Andrew Brooks	Microbiology and Immunology
The Role of CXCR7 in Tissue Fibrosis	Senior Research Officer & Lab Manager Catherine Kennedy, PhD	Microbiology and Immunology
The Role of enteric neurons in gastrointestinal symptoms associated with Autism Spectrum disorders	Research Project Leader Dr Elisa Hill-Yardin	Physiology
The role of glia in inner retinal changes during retinal degeneration	Head of Laboratory Professor Erica Fletcher	Anatomy and Neuroscience
The role of glial cells in retinal vascular disease	Head of Laboratory Professor Erica Fletcher	Anatomy and Neuroscience
The role of innate immune cells in protection and pathology during influenza virus infection	Project Leader Associate Professor Patrick Reading	Microbiology and Immunology
The role of microglia in age-related macular degeneration	Head of Laboratory Professor Erica Fletcher	Anatomy and Neuroscience
The role of mitochondria in Coxiella burnetii infection	Dr Diana Stojanovski	Biochemistry and Molecular Biology
The role of non-coding RNA in embryonic development	Project Leader Associate Professor Dagmar Wilhelm	Anatomy and Neuroscience
The role of protein modifications on muscle development	Research Project Leader Dr Benjamin Parker	Physiology
The role of resident memory T cells in barrier immunity and autoimmune disease	Project Leader Dr Laura Mackay	Microbiology and Immunology
The roles of metal ions in host-pathogen interaction	Research Project Leader Associate Professor Christopher McDevitt	Microbiology and Immunology
The unique features of visceral pain	Project Leader Professor Janet Keast	Anatomy and Neuroscience
Therapeutic potential of skeletal muscle plasticity and slow muscle programming for muscular dystrophy	Research Project Leader Professor Gordon Lynch	Physiology
Tissue communication in non-alcoholic fatty liver disease (NALFD) and liver fibrosis	Research Project Leader Dr Magdalene Montgomery	Physiology
Tracking phenotypically and functionally distinct T cell subsets via T cell repertoire diversity	Project Leader Associate Professor Katherine Kedzierska	Microbiology and Immunology
Transcriptional profiling of sensory neurons	Project Leader Associate Professor Stuart Mazzone	Anatomy and Neuroscience
Traumatic brain injury	Head of Laboratory Associate Professor Peter Crack	Pharmacology and Therapeutics
Treating the person not the disease	Dr David Ascher	Biochemistry and Molecular Biology
Uncovering the interplay between innate immunity and the blood brain barrier in disorders of the CNS	Project Leader Professor Christine Wells	Anatomy and Neuroscience
Understanding how Anthrax toxins function	Associate Professor Isabelle Rouiller	Biochemistry and Molecular Biology
Understanding how membrane-less organelles form with optogenetic tools	A/Prof Danny Hatters	Biochemistry and Molecular Biology
Understanding how metal ions traverse bacterial cell membranes	Research Project Leader Associate Professor Christopher McDevitt	Microbiology and Immunology
Understanding how the ATPase p97 functions at molecular level	Associate Professor Isabelle Rouiller	Biochemistry and Molecular Biology
Understanding immune dysfunction in acute myeloid leukemia	Dr Justine Mintern	Biochemistry and Molecular Biology
Understanding metabolic cross-talk in health and disease - Focus on type 2 diabetes and fatty liver	Research Project Leader Dr Magdalene Montgomery	Physiology
Understanding neuro-urothelial communication	Project Leader Professor Janet Keast	Anatomy and Neuroscience
Understanding the aetiology of hypertension	Research Project Leader Professor Andrew Allen	Physiology
Understanding the assembly of mitochondrial machines	Dr David Stroud	Biochemistry and Molecular Biology
Understanding the interaction between microbiota and T cell immunity	Project Leader Associate Professor Sammy Bedoui	Microbiology and Immunology
Understanding the Molecular Consequences of Mutations	Dr David Ascher David Ascher	Biochemistry and Molecular Biology
Understanding the regulation of tissue-resident memory T cell development	Project Leader Dr Laura Mackay	Microbiology and Immunology
Understanding the role of angiotensin in the rostral ventrolateral medulla	Research Project Leader Professor Andrew Allen	Physiology
Understanding ‘universal’ influenza-specific CD8+ T cell responses	Project Leader Associate Professor Katherine Kedzierska	Microbiology and Immunology
Unravelling the mysteries of E3 ubiquitin ligase in regulating skeletal muscle size and function	Research Project Leader Associate Professor Paul Gregorevic	Physiology
Using biochemical approaches to investigating the trafficking and mechanism of action of the antiviral molecule, IFITM3	Project Leader Dr Linda Wakim	Microbiology and Immunology
Using the immune system to kill tumours	Dr Justine Mintern	Biochemistry and Molecular Biology
Vaccination against liver-stage Plasmodium for malaria prevention	Project Leader Professor William (Bill) Heath	Microbiology and Immunology
van Driel laboratory: Immune responses to pathogens	Head of Laboratory Professor Ian van Driel	Biochemistry and Molecular Biology
Villadangos laboratory: Antigen presenting cells & molecules that initiate T cell immunity against pathogens and cancer	Head of Laboratory Professor Jose Villadangos	Microbiology and Immunology
Viral interactions with the innate immune system	Project Leader Associate Professor Patrick Reading	Microbiology and Immunology
Visualization and formation West Nile Virus replication complexes	Project Leader Professor Jason Mackenzie	Microbiology and Immunology
Watt laboratory: Metabolism and Diabetes	Head of Laboratory Professor Matthew Watt	Physiology
West Nile Virus replication and cellular stress responses	Project Leader Professor Jason Mackenzie	Microbiology and Immunology
What is the function of Sez6L2 in the forebrain?	Head of Laboratory Dr Jenny Gunnersen Project Leader Dr Kathryn Munro	Anatomy and Neuroscience
Wilhelm laboratory: Sex determination and disorders of sex development	Head of Laboratory Dr Dagmar Wilhelm	Anatomy and Neuroscience
Wlodek laboratory: Fetal, postnatal & adult physiology & disease laboratory	Head of Laboratory Professor Mary Wlodek	Physiology
“Clock-off time” for inflammation and remodelling in chronic inflammatory diseases: casein kinase inhibitors	Professor Alastair Stewart	Pharmacology and Therapeutics

238

Biomedical Neuroscience

Groups / Projects	Research Lead	Dept / Centre
A gut feeling about new therapies for glioma	Joint Project Leaders Dr Lincon Stamp & Dr Marlene Hao	Anatomy and Neuroscience
A gut feeling about new therapies for glioma treatment	Doctor Marlene Hao	Anatomy and Neuroscience
Allen laboratory: Central cardiovascular regulation	Head of Laboratory Professor Andrew Allen	Physiology
Angiotensin and chemoreceptor function	Research Project Leader Professor Andrew Allen	Physiology
Applications of Nanopore sequencing	Project Leader Dr Mike Clark	Anatomy and Neuroscience
Autologous stem cell therapies in Australia	Project Leader Associate Professor Megan Munsie	Anatomy and Neuroscience
Biomedical Neuroscience
Blood Atlas: Understanding cell state and differentiation using genomics data from blood cells	Project Leader Professor Christine Wells	Anatomy and Neuroscience
Bornstein laboratory: Enteric neuroscience	Head of Laboratory Professor Joel C Bornstein	Physiology
Bowel dysfunction in multiple sclerosis	Project Leader/Supervisor Dr Ruslan Pustovit	Anatomy and Neuroscience
Brain networks processing respiratory sensations	Project Leader Associate Professor Stuart Mazzone	Anatomy and Neuroscience
Can drug-like mimetics of BDNF promote remyelination after injury?	Dr Junhua Xiao	Anatomy and Neuroscience
Cappai laboratory: Neurodegeneration and Brain Injury	Head of Laboratory Professor Roberto Cappai	Pharmacology and Therapeutics
Cell state and cell fate: Systems biology approaches to understanding cell identity	Project Leader Professor Christine Wells	Anatomy and Neuroscience
Cheng laboratory: Stem cell and organ size control regulation	Head of Laboratory Dr Louise Cheng	Anatomy and Neuroscience
Clark laboratory: Transcriptomics and Neurogenetics	Head of Laboratory Dr Mike Clark	Anatomy and Neuroscience
Contemplating stem cells in society	Project Leader Dr Claire Tanner	Anatomy and Neuroscience
Crack laboratory: Neuropharmacology	Head of Laboratory Associate Professor Peter Crack	Pharmacology and Therapeutics
Crouch laboratory: Neurodegenerative disease	Head of Laboratory Dr Peter Crouch	Pharmacology and Therapeutics
de Iongh laboratory: Ocular development laboratory	Head of Laboratory Associate Professor Robb de Iongh	Anatomy and Neuroscience
Defining new roles for the Hippo signalling pathway in skeletal muscle	Research Project Leader Associate Professor Paul Gregorevic	Physiology
Dental morphology	Dr Varsha Pilbrow	Anatomy and Neuroscience
Designing new optogenetic tools for biomedical research	A/Prof Danny Hatters	Biochemistry and Molecular Biology
Developing innovative animal and cell culture models to study and treat muscular dystrophies	Research Project Leader Associate Professor Paul Gregorevic	Physiology
Towards understanding new therapies for obesity and diabetes: discovering new regulators of lipid metabolism	Research Project Leader Professor Matthew Watt	Physiology
Exercise-induced liver-muscle cross-talk and mitochondrial adaptations	Research Project Leader Dr Magdalene Montgomery	Physiology
Exploring new roles for the TGFβ signalling network as a key regulator of skeletal muscle in health and disease	Research Project Leader Associate Professor Paul Gregorevic	Physiology
Factors that accelerate photoreceptor death: The role of purines	Head of Laboratory Professor Erica Fletcher	Anatomy and Neuroscience
Fletcher laboratory: Visual neuroscience	Head of Laboratory Professor Erica Fletcher	Anatomy and Neuroscience
Furness laboratory: Digestive physiology and nutrition	Head of Laboratory Professor John Furness	Anatomy and Neuroscience
Genes underlying differentiation of enteric neuronal subtypes	Joint Project Leaders Dr Lincon Stamp	Anatomy and Neuroscience
Glial cells as a source of progenitor cells in degenerative disease	Head of Laboratory Professor Erica Fletcher	Anatomy and Neuroscience
Gooley laboratory: Structural biology of disease	Head of Laboratory Associate Professor Paul Gooley	Biochemistry and Molecular Biology
Gregorevic laboratory: Muscle Research and Therapeutics	Head of Laboratory Associate Professor Paul Gregorevic	Physiology
Griffin laboratory: Functional and mis-functional protein-protein interactions	Head of Laboratory Dr Michael Griffin	Biochemistry and Molecular Biology
Growth factors and peptide mimetics	Project Leader Dr Susan Northfield	Pharmacology and Therapeutics
Gunnersen laboratory: Neuron development and plasticity	Head of Laboratory Dr Jenny Gunnersen	Anatomy and Neuroscience
Hatters laboratory: Protein misfolding and proteostasis in neurodegenerative diseases	Head of Laboratory Associate Professor Danny Hatters	Biochemistry and Molecular Biology
How do dietary nutrients affect the ability of stem cells and stem cell-derived tumours to grow and divide?	Dr Louise Cheng	Anatomy and Neuroscience
How do neurons maintain their specialised status?	Dr Louise Cheng	Anatomy and Neuroscience
How do tumours compete with other tissues for resources?	Dr Louise Cheng	Anatomy and Neuroscience
How does GM-CSF prevent brain damage after traumatic injury?	Head of Laboratory Dr Jenny Gunnersen Project Leader Dr Sandy Shultz	Anatomy and Neuroscience
How early life experience influences brain myelination and function late in life?	Dr Junhua Xiao	Anatomy and Neuroscience
Hoyer laboratory: Translational neuroscience	Head of Laboratory Head of Department Deputy Head, School of Biomedical Sciences Professor Daniel Hoyer	Pharmacology and Therapeutics
Hughes & Northfield laboratory: Drug design	Joint Heads of Laboratory Associate Professor Tony Hughes & Dr Susan Northfield	Pharmacology and Therapeutics
Human brain networks processing respiratory sensations	Project Leader Associate Professor Stuart Mazzone	Anatomy and Neuroscience
Hypothalamic modulation of basal sympathetic activity	Research Project Leader Professor Andrew Allen	Physiology
Identifying factors that improve gastrointestinal function in Duchenne's muscular dystrophy	Research Project Leader Professor Gordon Lynch	Physiology
Improving recovery of injured visceral nerves and their spinal control centres	Project Leader Professor Janet Keast	Anatomy and Neuroscience
Innate immunity and neural injury	Head of Laboratory Associate Professor Peter Crack	Pharmacology and Therapeutics
Insulin on the Brain	Research Project Leader Dr Garron Dodd	Physiology
Investigating the molecular basis of central myelination and repair	Dr Junhua Xiao	Anatomy and Neuroscience
Is the “shed” form of Sez-6 proteins responsible for their synapse-promoting effects?	Head of Laboratory Dr Jenny Gunnersen Project Leader Dr Kathryn Munro	Anatomy and Neuroscience
Ivanusic laboratory: Pain and sensory mechanisms	Head of Laboratory Associate Professor Jason Ivanusic	Anatomy and Neuroscience
Keast & Osborne laboratory: Neural development, injury and pain	Joint Heads of Laboratory Professor Janet Keast & Dr Peregrine Osborne	Anatomy and Neuroscience
Kilpatrick laboratory: Neuroimmunology of Multiple Sclerosis	Head of Laboratory Professor Trevor Kilpatrick	Anatomy and Neuroscience
Learning from skeletal muscles to develop new treatments for cancer	Research Project Leader Associate Professor Paul Gregorevic	Physiology
Mapping the distribution of angiotensin receptors in the brain	Research Project Leader Professor Andrew Allen	Physiology
Mapping the proteome vulnerable to unfolding and aggregation under proteostasis stress	A/Prof Danny Hatters	Biochemistry and Molecular Biology
Mature and developing synaptic transmission between defined classes of enteric neurons	Research Project Leader Dr Jaime Foong	Physiology
Mazzone laboratory: Respiratory Sensory Neuroscience	Head of Research Group Associate Professor Stuart Mazzone	Anatomy and Neuroscience
Metabolic activity underlying enteric neurons, glia and progenitors	Dr Marlene Hao	Anatomy and Neuroscience
Modelling sensory neuron-epithelial interactions	Project Leader Associate Professor Stuart Mazzone	Anatomy and Neuroscience
Modulation of intestinal inflammation through nerve stimulation	Project Leader/Supervisor Dr Martin Stebbing	Anatomy and Neuroscience
Molecular mechanisms that contribute to skeletal pain	Head of Laboratory Associate Professor Jason Ivanusic	Anatomy and Neuroscience
Montgomery laboratory: Metabolic Tissue Cross-Talk	Head of Laboratory Dr Magdalene Montgomery	Physiology
Mueller laboratory: Visualising the immune system in action	Head of Laboratory Associate Professor Scott Mueller	Microbiology and Immunology
Mummy Studies	Dr Varsha Pilbrow	Anatomy and Neuroscience
Murray & Xiao laboratory: Neurotrophin and myelin	Joint Heads of Laboratory Dr Simon Murray & Dr Junhua Xiao	Anatomy and Neuroscience
Neuro-immune interactions: Nerve pathways that control inflammation in the intestine	Project Leader/Supervisor Dr Martin Stebbing	Anatomy and Neuroscience
Novel drugs and receptors for targeting neural control of digestive system functtion	Project Leader/Supervisor Dr Ruslan Pustovit	Anatomy and Neuroscience
Novel heteromeric receptors in gut control: ghrelin receptors and dopamine receptors working together Novel heteromeric receptors in gut control: ghrelin receptors and dopamine receptors working together	Project Leader/Supervisor Dr Linda Fothergill & Professor John Furness	Anatomy and Neuroscience
Novel technique to determine the pKA of clonidine at prejunctional α2-adrenoceptors in sympathetic transmission	Project Leader Professor James Angus	Pharmacology and Therapeutics
Oxidative stress and neural injury	Head of Laboratory Associate Professor Peter Crack	Pharmacology and Therapeutics
Pain management using ultrasound-guided local anaesthetic techniques	Head of Laboratory Associate Professor Jason Ivanusic	Anatomy and Neuroscience
Parker Laboratory: Structural biology and computational drug design	Head of Laboratory and Director, Bio21 Institute Professor Michael Parker	Biochemistry and Molecular Biology
Patient voices: An analysis of patients’ information-based priorities and needs	Project Leader Associate Professor Megan Munsie	Anatomy and Neuroscience
Pilbrow laboratory: Physical (biological) anthropology	Head of Laboratory Dr Varsha Pilbrow	Anatomy and Neuroscience
Potential of stem cell therapy to treat Hirschsprung’s disease	Dr Lincon Stamp	Anatomy and Neuroscience
Principles of Peripheral Nerve Myelination	Dr Simon Murray	Anatomy and Neuroscience
Prognostic biomarker and therapeutic target discovery in stroke	Project Leader Dr Jonathon Mangum	Pharmacology and Therapeutics
Pébay laboratory: Stem Cell Disease Modelling	Head of Laboratory Professor Alice Pebay	Anatomy and Neuroscience
Relaxin family peptide hormones	Project Leader Associate Professor Tony Hughes	Pharmacology and Therapeutics
Risk genes for neuropsychiatric disorders	Project Leader Dr Mike Clark	Anatomy and Neuroscience
Role of long noncoding RNAs in neurological disorders	Project Leader Dr Mike Clark	Anatomy and Neuroscience
Rouiller laboratory: Understanding how molecular machines function through cryo-electron microscopy	Associate Professor Isabelle Rouiller	Biochemistry and Molecular Biology
Rutar laboratory: Ocular Neuroimmunology	Head of Laboratory Dr Matt Rutar	Anatomy and Neuroscience
Saunders laboratory: Developmental neuroscience and neurotrauma	Head of Laboratory Professor Norman Saunders	Pharmacology and Therapeutics
Skeletal morphology	Dr Varsha Pilbrow	Anatomy and Neuroscience
Stamp & Hao laboratory: Development of the enteric nervous system	Joint Heads of Laboratory Dr Lincon Stamp & Dr Marlene Hao	Anatomy and Neuroscience
Stroke	Head of Laboratory Associate Professor Peter Crack	Pharmacology and Therapeutics
Structural Neurobiology	Professor Michael Parker	Biochemistry and Molecular Biology
The amyloidogenic protease inhibitor Cystatin C in health and disease	Prof. Jose Villadangos	Biochemistry and Molecular Biology
The Enteric Neural Circuitry Activated During Bacterial-toxin Induced Diarrhoea	Research Project Leader Dr Jaime Foong	Physiology
The gastrointestinal complications of Parkinson's Disease	Project Leader/Supervisor Dr Shanti Diwakarla	Anatomy and Neuroscience
The GDNF family, peripheral nerve regeneration and pain	Project Leader Professor Janet Keast	Anatomy and Neuroscience
The heart as a central player in tissue cross-talk	Research Project Leader Dr Magdalene Montgomery	Physiology
The link between cardiovascular disease and neurodegeneration – focus on Alzheimer’s disease	Project Leader Associate Professor Christine Wright	Pharmacology and Therapeutics
The Role of enteric neurons in gastrointestinal symptoms associated with Autism Spectrum disorders	Research Project Leader Dr Elisa Hill-Yardin	Physiology
The role of glia in inner retinal changes during retinal degeneration	Head of Laboratory Professor Erica Fletcher	Anatomy and Neuroscience
The role of glial cells in retinal vascular disease	Head of Laboratory Professor Erica Fletcher	Anatomy and Neuroscience
The role of microglia in age-related macular degeneration	Head of Laboratory Professor Erica Fletcher	Anatomy and Neuroscience
The Stemformatics Stem Cell Atlas	Project Leader Professor Christine Wells	Anatomy and Neuroscience
The taxonomy of enteroendocrine cells and their innervation	Project Supervisor Professor John B Furness	Anatomy and Neuroscience
The unique features of visceral pain	Project Leader Professor Janet Keast	Anatomy and Neuroscience
Tissue communication in non-alcoholic fatty liver disease (NALFD) and liver fibrosis	Research Project Leader Dr Magdalene Montgomery	Physiology
Transcriptional profiling of sensory neurons	Project Leader Associate Professor Stuart Mazzone	Anatomy and Neuroscience
Traumatic brain injury	Head of Laboratory Associate Professor Peter Crack	Pharmacology and Therapeutics
Understanding how membrane-less organelles form with optogenetic tools	A/Prof Danny Hatters	Biochemistry and Molecular Biology
Understanding how the ATPase p97 functions at molecular level	Associate Professor Isabelle Rouiller	Biochemistry and Molecular Biology
Understanding interactions between gut epithelial stem cells and enteric neurons	Dr Lincon Stamp	Anatomy and Neuroscience
Understanding metabolic cross-talk in health and disease - Focus on type 2 diabetes and fatty liver	Research Project Leader Dr Magdalene Montgomery	Physiology
Understanding neuro-urothelial communication	Project Leader Professor Janet Keast	Anatomy and Neuroscience
Understanding the aetiology of hypertension	Research Project Leader Professor Andrew Allen	Physiology
Understanding the role of angiotensin in the rostral ventrolateral medulla	Research Project Leader Professor Andrew Allen	Physiology
Unravelling the mysteries of E3 ubiquitin ligase in regulating skeletal muscle size and function	Research Project Leader Associate Professor Paul Gregorevic	Physiology
Watt laboratory: Metabolism and Diabetes	Head of Laboratory Professor Matthew Watt	Physiology
What is the function of Sez6L2 in the forebrain?	Head of Laboratory Dr Jenny Gunnersen Project Leader Dr Kathryn Munro	Anatomy and Neuroscience
Wilkinson-Berka laboratory: Retinal vascular biology and inflammation	Head of Laboratory Professor Jennifer Wilkinson-Berka	Anatomy and Neuroscience

119

Stem Cells

Groups / Projects	Research Lead	Dept / Centre
A gut feeling about new therapies for glioma	Joint Project Leaders Dr Lincon Stamp & Dr Marlene Hao	Anatomy and Neuroscience
A gut feeling about new therapies for glioma treatment	Doctor Marlene Hao	Anatomy and Neuroscience
Analysing genetic roles of RNA-binding proteins and alternative splicing in Drosophila stem cells	Project Leader Professor Gary Hime	Anatomy and Neuroscience
Autologous stem cell therapies in Australia	Project Leader Associate Professor Megan Munsie	Anatomy and Neuroscience
Blood Atlas: Understanding cell state and differentiation using genomics data from blood cells	Project Leader Professor Christine Wells	Anatomy and Neuroscience
Cell state and cell fate: Systems biology approaches to understanding cell identity	Project Leader Professor Christine Wells	Anatomy and Neuroscience
Cellular trafficking and male fertility	Project Leader Professor Gary Hime	Anatomy and Neuroscience
Cheng laboratory: Stem cell and organ size control regulation	Head of Laboratory Dr Louise Cheng	Anatomy and Neuroscience
Clark laboratory: Transcriptomics and Neurogenetics	Head of Laboratory Dr Mike Clark	Anatomy and Neuroscience
Contemplating stem cells in society	Project Leader Dr Claire Tanner	Anatomy and Neuroscience
EMT regulators in intestinal and germline stem cells	Project Leader Professor Gary Hime	Anatomy and Neuroscience
Functional genomic screens for cardiovascular drug discovery	Research Project Leader Dr Enzo Porrello	Physiology
Genes underlying differentiation of enteric neuronal subtypes	Joint Project Leaders Dr Lincon Stamp	Anatomy and Neuroscience
Hime laboratory: Stem cell genetics and Drosophila models of human disease	Head of Laboratory Professor Gary Hime	Anatomy and Neuroscience
How do dietary nutrients affect the ability of stem cells and stem cell-derived tumours to grow and divide?	Dr Louise Cheng	Anatomy and Neuroscience
How do neurons maintain their specialised status?	Dr Louise Cheng	Anatomy and Neuroscience
How do tumours compete with other tissues for resources?	Dr Louise Cheng	Anatomy and Neuroscience
Investigating the Dystrophin-Glycoprotein Complex to Protect Muscles from Wasting Conditions	Research Project Leader Professor Gordon Lynch	Physiology
Investigating the role of cachexia in the response to surgical tumour resection in mice	Research Project Leader Professor Gordon Lynch	Physiology
Lynch laboratory: Basic and clinical myology	Head of Laboratory Professor Gordon Lynch	Physiology
Metabolic activity underlying enteric neurons, glia and progenitors	Dr Marlene Hao	Anatomy and Neuroscience
Metabolic reprogramming of skeletal muscle stem cells	Research Project Leader Professor Gordon Lynch	Physiology
Modeling human heart development using human cardiac organoids	Research Project Leader Dr Enzo Porrello	Physiology
Molecular and cellular analysis of mammalian ovary development and disease	Project Leader Associate Professor Dagmar Wilhelm	Anatomy and Neuroscience
Munsie laboratory: Ethical, legal and social implications of stem cell research	Head of Laboratory Associate Professor Megan Munsie	Anatomy and Neuroscience
Novel regulators of germline stem cells	Project Leader Professor Gary HIme	Anatomy and Neuroscience
Patient voices: An analysis of patients’ information-based priorities and needs	Project Leader Associate Professor Megan Munsie	Anatomy and Neuroscience
Porrello laboratory: Cardiac Regeneration	Head of Laboratory Enzo Porrello	Physiology
Post-natal control of cardiac gene regulatory networks	Research Project Leader Dr Enzo Porrello	Physiology
Potential of stem cell therapy to treat Hirschsprung’s disease	Dr Lincon Stamp	Anatomy and Neuroscience
Pébay laboratory: Stem Cell Disease Modelling	Head of Laboratory Professor Alice Pebay	Anatomy and Neuroscience
Risk genes for neuropsychiatric disorders	Project Leader Dr Mike Clark	Anatomy and Neuroscience
Stamp & Hao laboratory: Development of the enteric nervous system	Joint Heads of Laboratory Dr Lincon Stamp & Dr Marlene Hao	Anatomy and Neuroscience
Stem Cells
The Stemformatics Stem Cell Atlas	Project Leader Professor Christine Wells	Anatomy and Neuroscience
Therapeutic potential of skeletal muscle plasticity and slow muscle programming for muscular dystrophy	Research Project Leader Professor Gordon Lynch	Physiology
Transcriptional regulation of intestinal organoid differentiation	Project Leader Professor Gary Hime	Anatomy and Neuroscience
Understanding interactions between gut epithelial stem cells and enteric neurons	Dr Lincon Stamp	Anatomy and Neuroscience
Wells laboratory: Stem cell systems	Head of Laboratory Professor Christine Wells	Anatomy and Neuroscience

Systems Biology

Groups / Projects	Research Lead	Dept / Centre
Application of genomics to public health and clinical microbiology	Project Leader Professor Ben Howden	Microbiology and Immunology
Applications of Nanopore sequencing	Project Leader Dr Mike Clark	Anatomy and Neuroscience
Australian Venom Research Unit	Head of Unit Dr David Williams	Pharmacology and Therapeutics
Blood Atlas: Understanding cell state and differentiation using genomics data from blood cells	Project Leader Professor Christine Wells	Anatomy and Neuroscience
Bo&MeRanG Research Projects	Melbourne Coordinator Dr Marie Greyer
Cell state and cell fate: Systems biology approaches to understanding cell identity	Project Leader Professor Christine Wells	Anatomy and Neuroscience
Clinical Proteomics	Project Leader Dr Jonathon Mangum	Pharmacology and Therapeutics
Developing a novel class of therapeutics for muscle wasting and frailty	Research Project Leader Dr Benjamin Parker	Physiology
Towards understanding new therapies for obesity and diabetes: discovering new regulators of lipid metabolism	Research Project Leader Professor Matthew Watt	Physiology
Enterococcus faecium	Project Leader Professor Ben Howden	Microbiology and Immunology
Exercise-induced liver-muscle cross-talk and mitochondrial adaptations	Research Project Leader Dr Magdalene Montgomery	Physiology
Harrap laboratory: Genetic physiology	Head of Laboratory Professor Stephen Harrap	Physiology
Hatters laboratory: Protein misfolding and proteostasis in neurodegenerative diseases	Head of Laboratory Associate Professor Danny Hatters	Biochemistry and Molecular Biology
Howden laboratory: Molecular epidemiology, genomics and pathogenesis of antimicrobial resistant bacteria	Head of Laboratory \| Director of MDU Professor Ben Howden	Microbiology and Immunology
Improving the diagnostic outcomes of patients with mitochondrial disease	Dr David Stroud	Biochemistry and Molecular Biology
Investigating mechanisms of protein trafficking to human mitochondria	Dr Diana Stojanovski	Biochemistry and Molecular Biology
Ivanusic laboratory: Pain and sensory mechanisms	Head of Laboratory Associate Professor Jason Ivanusic	Anatomy and Neuroscience
Molecular mechanisms that contribute to skeletal pain	Head of Laboratory Associate Professor Jason Ivanusic	Anatomy and Neuroscience
Montgomery laboratory: Metabolic Tissue Cross-Talk	Head of Laboratory Dr Magdalene Montgomery	Physiology
Mycobacterium ulcerans	Project Leader Professor TIm Stinear	Microbiology and Immunology
Pain management using ultrasound-guided local anaesthetic techniques	Head of Laboratory Associate Professor Jason Ivanusic	Anatomy and Neuroscience
Parker laboratory: Metabolic Proteomics & Signal Transduction	Head of Laboratory Dr Benjamin Parker	Physiology
Risk genes for neuropsychiatric disorders	Project Leader Dr Mike Clark	Anatomy and Neuroscience
Role of long noncoding RNAs in neurological disorders	Project Leader Dr Mike Clark	Anatomy and Neuroscience
Skeletal muscle signal transduction related to exercise, metabolic disease and human health	Research Project Leader Dr Benjamin Parker	Physiology
Small molecules for BIG targets- Targeting protein-protein interactions with fragments	Dr David Ascher	Biochemistry and Molecular Biology
Staphylococcus aureus & Enterococcus faecium	Project Leader Professor Tim Stinear	Microbiology and Immunology
Staphylococcus aureus and Staphylococcus epidermidis	Project Leader Professor Ben Howden	Microbiology and Immunology
Stinear laboratory: Bacterial pathogenomics	Head of Laboratory Professor Tim Stinear	Microbiology and Immunology
Stroud laboratory: Mitochondrial Systems Biology	Head of Research Group Dr David Stroud	Biochemistry and Molecular Biology
Systems Biology
Systems genetics of muscle metabolism	Research Project Leader Dr Benjamin Parker	Physiology
The Cardiovascular Pharmacology of Snake Venoms From Papua New Guinea and Australia	Project Leader Associate Professor Christine Wright	Pharmacology and Therapeutics
The heart as a central player in tissue cross-talk	Research Project Leader Dr Magdalene Montgomery	Physiology
The role of protein modifications on muscle development	Research Project Leader Dr Benjamin Parker	Physiology
The Stemformatics Stem Cell Atlas	Project Leader Professor Christine Wells	Anatomy and Neuroscience
The Treatment of Papuan Taipan Envenoming in Papua New Guinea	Project Leader Dr David Williams	Pharmacology and Therapeutics
Tissue communication in non-alcoholic fatty liver disease (NALFD) and liver fibrosis	Research Project Leader Dr Magdalene Montgomery	Physiology
Treating the person not the disease	Dr David Ascher	Biochemistry and Molecular Biology
Understanding metabolic cross-talk in health and disease - Focus on type 2 diabetes and fatty liver	Research Project Leader Dr Magdalene Montgomery	Physiology
Understanding the assembly of mitochondrial machines	Dr David Stroud	Biochemistry and Molecular Biology
Watt laboratory: Metabolism and Diabetes	Head of Laboratory Professor Matthew Watt	Physiology
Wells laboratory: Stem cell systems	Head of Laboratory Professor Christine Wells	Anatomy and Neuroscience

Therapeutics & Translation

Groups / Projects	Research Lead	Dept / Centre
A universal vaccine against influenza A	Project Leader Professor David Jackson	Microbiology and Immunology
Ascher laboratory: Structural biology and bioinformatics	Head of Laboratory Dr David Ascher	Biochemistry and Molecular Biology
Australian bite and sting trends: Australian Venomous Injury Project (AVIP)	Project Leader Dr Ronelle Welton	Pharmacology and Therapeutics
Australian Venom Research Unit	Head of Unit Dr David Williams	Pharmacology and Therapeutics
Autologous stem cell therapies in Australia	Project Leader Associate Professor Megan Munsie	Anatomy and Neuroscience
Biolpolymer-based vaccine delivery systems	Project Leader Professor David Jackson	Microbiology and Immunology
Bo&MeRanG Research Projects	Melbourne Coordinator Dr Marie Greyer
Can drug-like mimetics of BDNF promote remyelination after injury?	Dr Junhua Xiao	Anatomy and Neuroscience
Characterising the pathways responsible for ICU-acquired weakness	Research Project Leader Dr René Koopman	Physiology
Contemplating stem cells in society	Project Leader Dr Claire Tanner	Anatomy and Neuroscience
Crack laboratory: Neuropharmacology	Head of Laboratory Associate Professor Peter Crack	Pharmacology and Therapeutics
Defining new roles for the Hippo signalling pathway in skeletal muscle	Research Project Leader Associate Professor Paul Gregorevic	Physiology
Developing innovative animal and cell culture models to study and treat muscular dystrophies	Research Project Leader Associate Professor Paul Gregorevic	Physiology
Developing new therapies for Systemic Lupus Erythematosus	Senior Research Officer & Lab Manager Catherine Kennedy, PhD	Microbiology and Immunology
Development of a self-adjuvanting vaccine for enterotoxigenic Escherichia coli (ETEC)	Project Leader Professor David Jackson	Microbiology and Immunology
Development of Novel antimalarial drugs	Professor Leann Tilley	Biochemistry and Molecular Biology
Towards understanding new therapies for obesity and diabetes: discovering new regulators of lipid metabolism	Research Project Leader Professor Matthew Watt	Physiology
Edgington-Mitchell laboratory: Protease Pathophysiology	Head of Research Group Dr Laura Edgington-Mitchell	Biochemistry and Molecular Biology
Endothelin pharmacology in the setting of pulmonary hypertension	Project Leader Professor James Angus	Pharmacology and Therapeutics
Establishing the effect of glycine/serine metabolism on skeletal muscle cell growth	Research Project Leader Dr René Koopman	Physiology
Exercise-induced liver-muscle cross-talk and mitochondrial adaptations	Research Project Leader Dr Magdalene Montgomery	Physiology
Exploring new roles for the TGFβ signalling network as a key regulator of skeletal muscle in health and disease	Research Project Leader Associate Professor Paul Gregorevic	Physiology
Furness laboratory: Digestive physiology and nutrition	Head of Laboratory Professor John Furness	Anatomy and Neuroscience
Gleeson laboratory: Membrane trafficking and protein sorting in health and disease and development of new therapeutics	Head of Laboratory Professor Paul Gleeson	Biochemistry and Molecular Biology
Gooley laboratory: Structural biology of disease	Head of Laboratory Associate Professor Paul Gooley	Biochemistry and Molecular Biology
Gregorevic laboratory: Muscle Research and Therapeutics	Head of Laboratory Associate Professor Paul Gregorevic	Physiology
Growth factors and peptide mimetics	Project Leader Dr Susan Northfield	Pharmacology and Therapeutics
How early life experience influences brain myelination and function late in life?	Dr Junhua Xiao	Anatomy and Neuroscience
Hughes & Northfield laboratory: Drug design	Joint Heads of Laboratory Associate Professor Tony Hughes & Dr Susan Northfield	Pharmacology and Therapeutics
Innovative approaches to prepare synthetic, partially synthetic and natural product-based vaccines	Project Leader Professor David Jackson	Microbiology and Immunology
Investigating the molecular basis of central myelination and repair	Dr Junhua Xiao	Anatomy and Neuroscience
Ivanusic laboratory: Pain and sensory mechanisms	Head of Laboratory Associate Professor Jason Ivanusic	Anatomy and Neuroscience
Jackson laboratory: Synthetic vaccine design	Head of Laboratory Professor David Jackson	Microbiology and Immunology
Koopman laboratory: Clinical nutrition and muscle metabolism	Head of Laboratory Dr René Koopman	Physiology
Learning from skeletal muscles to develop new treatments for cancer	Research Project Leader Associate Professor Paul Gregorevic	Physiology
Lew laboratory: Theoretical and empirical pharmacology	Head of Laboratory Dr Michael Lew	Pharmacology and Therapeutics
Lipopeptide-based adjuvanting systems	Project Leader Professor David Jackson	Microbiology and Immunology
Mangum Lab: Translational Proteomics	Head of Laboratory Dr Jonathan Mangum	Pharmacology and Therapeutics
McConville laboratory: Molecular microbiology	Head of Laboratory Professor Malcolm McConville	Biochemistry and Molecular Biology
Molecular mechanisms of drug resistance in cancer	Project Leader Dr Jonathon Mangum	Pharmacology and Therapeutics
Molecular mechanisms that contribute to skeletal pain	Head of Laboratory Associate Professor Jason Ivanusic	Anatomy and Neuroscience
Montgomery laboratory: Metabolic Tissue Cross-Talk	Head of Laboratory Dr Magdalene Montgomery	Physiology
Munsie laboratory: Ethical, legal and social implications of stem cell research	Head of Laboratory Associate Professor Megan Munsie	Anatomy and Neuroscience
Murray & Xiao laboratory: Neurotrophin and myelin	Joint Heads of Laboratory Dr Simon Murray & Dr Junhua Xiao	Anatomy and Neuroscience
Pain management using ultrasound-guided local anaesthetic techniques	Head of Laboratory Associate Professor Jason Ivanusic	Anatomy and Neuroscience
Patient voices: An analysis of patients’ information-based priorities and needs	Project Leader Associate Professor Megan Munsie	Anatomy and Neuroscience
Preclinical pharmacology – cardiovascular efficacy and safety R&D	Project Leader Associate Professor Christine Wright	Pharmacology and Therapeutics
Principles of Peripheral Nerve Myelination	Dr Simon Murray	Anatomy and Neuroscience
Prognostic biomarker and therapeutic target discovery in stroke	Project Leader Dr Jonathon Mangum	Pharmacology and Therapeutics
Ralph laboratory: Drug targets and gene regulation in Plasmodium falciparum	Head of Laboratory Dr Stuart Ralph	Biochemistry and Molecular Biology
Relaxin family peptide hormones	Project Leader Associate Professor Tony Hughes	Pharmacology and Therapeutics
Restoring immunocompetency in Chronic Lymphocytic Leukemia	Senior Research Officer & Lab Manager Catherine Kennedy, PhD	Microbiology and Immunology
Stewart Laboratory: Mechanopharmacology	Head of Laboratory Professor Alastair Stewart	Pharmacology and Therapeutics
The Cardiovascular Pharmacology of Snake Venoms From Papua New Guinea and Australia	Project Leader Associate Professor Christine Wright	Pharmacology and Therapeutics
The heart as a central player in tissue cross-talk	Research Project Leader Dr Magdalene Montgomery	Physiology
The link between cardiovascular disease and neurodegeneration – focus on Alzheimer’s disease	Project Leader Associate Professor Christine Wright	Pharmacology and Therapeutics
The Role of CXCR7 in Tissue Fibrosis	Senior Research Officer & Lab Manager Catherine Kennedy, PhD	Microbiology and Immunology
The Treatment of Papuan Taipan Envenoming in Papua New Guinea	Project Leader Dr David Williams	Pharmacology and Therapeutics
Therapeutics & Translation
Tilley laboratory: Measuring and modelling malaria parasites to develop new antimalarials	Head of Laboratory, ARC Australian Laureate Fellow Professor Leann Tilley	Biochemistry and Molecular Biology
Tissue communication in non-alcoholic fatty liver disease (NALFD) and liver fibrosis	Research Project Leader Dr Magdalene Montgomery	Physiology
Trovafloxacin – an antibiotic with additional properties	Project Leader Professor James Angus	Pharmacology and Therapeutics
Understanding metabolic cross-talk in health and disease - Focus on type 2 diabetes and fatty liver	Research Project Leader Dr Magdalene Montgomery	Physiology
Unravelling the mysteries of E3 ubiquitin ligase in regulating skeletal muscle size and function	Research Project Leader Associate Professor Paul Gregorevic	Physiology
Velkov laboratory: Antiinfective pharmacology	Head of Laboratory Associate Professor Tony Velkov	Pharmacology and Therapeutics
Watt laboratory: Metabolism and Diabetes	Head of Laboratory Professor Matthew Watt	Physiology
Wilkinson-Berka laboratory: Retinal vascular biology and inflammation	Head of Laboratory Professor Jennifer Wilkinson-Berka	Anatomy and Neuroscience
Williamson laboratory: Public health, AMR, epidemiology and microbiology	Head of Laboratory Associate Professor Deborah Williamson	Microbiology and Immunology
Wright laboratory: Cardiovascular Therapeutics Unit	Head of Laboratory Associate Professor Christine E Wright	Pharmacology and Therapeutics

Scholarship of Teaching and Learning

Groups / Projects	Research Lead	Dept / Centre
Clark: Anatomy, Neuroscience and Cell Biology Education Scholarship	Dr Charlotte Clark	Anatomy and Neuroscience
Heather Verkade: Molecular Biology Education Scholarship	Associate Professor Heather Verkade	Biochemistry and Molecular Biology
Lim: Education Scholarship	Dr Saw Hoon Lim	Biochemistry and Molecular Biology
Mulhern: Biochemistry and Molecular Biology Education Scholarship	Associate Professor Terry Mulhern	Biochemistry and Molecular Biology
Post: Online Teaching Delivery Neuroscience & Anatomy	MSc Ger Post	Anatomy and Neuroscience
Rank: Anatomy Education Scholarship	Dr Michelle Rank	Anatomy and Neuroscience
Scholarship of Teaching and Learning
Waller: Microbiology Education Scholarship	Associate Professor Karena Waller	Microbiology and Immunology
Wijburg: Infection and Immunity Education Scholarship	Associate Professor Odilia Wijburg	Microbiology and Immunology
Willems-Jones: Biochemistry & Molecular Biology Education Scholarship	Dr Amber Willems-Jones	Biochemistry and Molecular Biology