Live imaging of cellular signalling in vascular development and disease models
Directly observing key molecules and pathways as they act to control tissue formation, or as they drive pathological phenotypes, is a major challenge that is rapidly becoming a reality. We are developing biosensors that report signalling downstream of CCBE1/VEGFC/VEGFR3 activation, including a reporter of Erk activity. This allows us to see real-time dynamic pathway activation in the context of tissue and cellular interactions in normal development and disease models. This work has uncovered unexpected mechanisms in angiogenesis during wound repair and allowed us to study cell-cell adhesion mechanics in developing tissues. We are currently diversifying our biosensor tools and applying these imaging approaches to cellular resolution studies of lymphangiogenesis, the BBB, lymphatic malformation and metastatic cellular interactions.
This research project is available to Honours students to join as part of their thesis.
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