Exercise-induced liver-muscle cross-talk and mitochondrial adaptations

Project Details

Despite the substantial obesity epidemic in developed countries, there is currently no medication that effectively reduces obesity. In this respect, lifestyle interventions such as exercise and dietary interventions are commonly prescribed as the first-choice treatment. Exercise training is known to improve obesity and insulin sensitivity, with major changes in mitochondrial capacity observed in muscle. While it has been shown that muscle also responds to exercise training with adaptation in protein secretion (ie. myokine secretion), less is known about similar adaptations in the liver.

We have novel data showing that the liver secretome (hepatokines) is substantially remodelled after exercise training, with these changes potentially driving mitochondrial adaptations in muscle. We now aim to assess various targets in respect to their effects on muscle energy metabolism.

Research Opportunities

This research project is available to Honours students to join as part of their thesis.
Please contact the Research Group Leader to discuss your options.

Research Publications

View Dr Montgomery's latest PubMed publications listing here

Research Group

Montgomery laboratory: Metabolic Tissue Cross-Talk

Faculty Research Themes


School Research Themes

Biomedical Neuroscience, Cell Signalling, Systems Biology, Molecular Mechanisms of Disease, Therapeutics & Translation

Key Contact

For further information about this research, please contact the research group leader.

Department / Centre

Anatomy and Physiology

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