Immunosurveillance pathways in brain cancer

Project Details

Growth factor (GF) surveillance is a new mode of cancer immunosurveillance in which the immune system responds to GFs over-expressed by cancers and infected cells. Our work has implicated natural killer (NK) cells and GF surveillance in the control of glioblastoma, a high grade glioma with poor survival. In collaboration with Theo Mantamadiotis’ group, Alex’s group is assessing the role of NK cells and other immune cell subsets in immunosurveillance of the brain using a transgenic mouse model of glioma.


Dr Patrick Constantinescu, Research Officer

Alexander James Sedgwick, Masters student

Yuhan Sun, Masters student

Research Opportunities

This research project is available to Honours students to join as part of their thesis.
Please contact the Research Group Leader to discuss your options.

Research Group

Barrow laboratory: Tissue immunosurveillance strategies

Faculty Research Themes

Infection and Immunology, Cancer

School Research Themes

Cancer in Biomedicine

Key Contact

For further information about this research, please contact the research group leader.

Department / Centre

Microbiology and Immunology

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