Cell surface receptors for attachment and entry of influenza virus into cells of the innate immune system
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Associate Professor Patrick Reading+61 3 9342 9326
Project Details
Airway macrophages and dendritic cells (DC) are important components of innate host defense and play a critical role in limiting the severity of influenza infection. Detailed information regarding the mechanisms by which macrophages and DC recognize influenza virus for attachment, uptake and destruction are lacking. Our group has recently identified specific receptors involved in influenza virus infection of macrophages and DC. We now aim to investigate virus-encoded and host-encoded determinants that modulate efficiency of virus binding and infection. These studies will provide novel information regarding how influenza virus is first recognized by cells of the innate immune system as well as insight into why virulent strains circumvent uptake and destruction by macrophages and DC.
Research Group
Reading laboratory: Innate immune detection and response to respiratory virus infections
Faculty Research Themes
School Research Themes
Molecular Mechanisms of Disease
Key Contact
For further information about this research, please contact the research group leader.
Department / Centre
MDHS Research library
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