Towards understanding new therapies for obesity and diabetes: discovering new regulators of lipid metabolism

Project Details

Cells maintain a delicate balance of lipid (fat) synthesis and breakdown and dysregulation of lipid balance underpins the development of many diseases including type 2 diabetes, cardiovascular disease, some cancers and fatty liver disease.

The aim of this study is to identify novel proteins that are essential for regulating lipid balance in cells, to determine the expression pattern of these proteins in metabolic diseases (e.g. obesity, diabetes and fatty liver disease) and to determine whether altering the expression of these protiens influences metabolism in cells. This will be achieved by combining proteomic profiling (with space and time resolution) and deletion of the target proteins using a state-of-art CRISPR-Cas9 gene editing tool.

The project will also assess the therapeutic relevance of targeting the newly discovered proteins for the treatment of metabolic diseases.


Professor Matthew Watt, Head of Department of Physiology, Head of Laboratory

Dr Magda Montgomery, Senior Research Fellow

Dr Ayenachew Bezawork-Geleta, Research Fellow

Dr Jacquie Bayliss, Research Assistant

Dr Paula Miotto, Research Fellow

Research Opportunities

This research project is available to Honours students to join as part of their thesis.
Please contact the Research Group Leader to discuss your options.

Research Group

Watt laboratory: Metabolism and Diabetes

Faculty Research Themes

Cancer, Neuroscience

School Research Themes

Cancer in Biomedicine, Biomedical Neuroscience, Cell Signalling, Systems Biology, Molecular Mechanisms of Disease, Therapeutics & Translation

Key Contact

For further information about this research, please contact the research group leader.

Department / Centre

Anatomy and Physiology

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