Understanding the regulation of tissue-resident memory T cell development

Project Details

Laura’s group’s work has shown that tissue-resident memory T cells (Trm) are phenotypically and functionally distinct to memory T cells in the circulation. They have found that Trm development is a multistep process that requires the action of several molecules, and that these cells acquire a unique transcriptional profile during their differentiation. Using several different infectious models including Influenza, herpes simplex virus, Listeria and LCMV, Laura’s group is investigating the regulatory cues and mechanisms that govern Trm cell development in different tissues, with a focus on the transcriptional networks that regulate commitment to this immune cell lineage.

Research Group

Mackay laboratory: Tissue-resident memory T cells; lymphocyte differentiation; peripheral immunity


Faculty Research Themes

Infection and Immunology

School Research Themes

Molecular Mechanisms of Disease


Key Contact

For further information about this research, please contact the research group leader.

Department / Centre

Microbiology and Immunology

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