Molecular Mechanisms of Disease

Groups / Projects	Research Lead	Dept / Centre
Understanding the plasticity of skeletal muscle in health and disease	Research Project Leader Professor Gordon Lynch
"Clock-off time" for inflammation and remodelling in chronic inflammatory diseases: casein kinase inhibitors	Primary Supervisor Professor Alastair Stewart
Adaptive remodelling of metabolism during liver regeneration	Project Leader Dr Andrew Cox
Angiotensin and chemoreceptor function	Research Project Leader Professor Andrew Allen
Antibody dependent cellular cytotoxicity - a neglected anti-HIV iImmune response!	Project Leaders Professor Stephen Kent & Dr Amy Chung
Antimicrobial resistant bacterial pathogens	Project Leader Professor Ben Howden
Application of genomics to public health and clinical microbiology	Project Leader Professor Ben Howden
Autophagy and Norovirus replication	Professor Jason Mackenzie
Bacterial secretion systems	Project Leader Dr Debnath Ghosal
Bedoui laboratory: Innate and adaptive interactions in immunity to infection	Head of Laboratory Professor Sammy Bedoui
Bornstein laboratory: Enteric neuroscience	Head of Laboratory Professor Joel C Bornstein
Brain networks processing respiratory sensations	Project Leader Professor Stuart Mazzone
Brooks laboratory: Innate immunity; anti-viral immunity	Head of Laboratory Professor Andrew Brooks
Brown laboratory: Behavioural neuropharmacology	Head of Laboratory Dr Robyn M Brown
Brown laboratory: Cancer metabolism	Head of Laboratory Dr Kristin Brown
Building a urogenital nervous system connectome	Project Leaders Professor Janet Keast / Dr Peregrine Osborne
Cell surface receptors for attachment and entry of influenza virus into cells of the innate immune system	Project Leader Associate Professor Patrick Reading
Characterising the cellular roles of metals	Research Project Leader Associate Professor Christopher McDevitt
Chronic immune activation during treated HIV disease	Project Leader Professor Damian Purcell
Chung laboratory: Investigating the role of functional antibodies against Mycobacterium tuberculosis	Head of Laboratory Dr Amy Chung
Clark laboratory: Transcriptomics and Neurogenetics	Head of Laboratory Dr Mike Clark
Coding the future: next-gen bioinformatic tools for nanopore data	Project Leader Dr Mike Clark
Coin Laboratory: Genomics and bioinformatics in infectious disease and cancer	Head of Laboratory Professor Lachlan Coin
Correlates of severe and fatal influenza disease in high-risk groups	Head of Laboratory Associate Professor Katherine Kedzierska
Cox laboratory: Metabolic Regulation of Growth	Head of Laboratory Dr Andrew Cox
Crack laboratory: Neuropharmacology	Head of Laboratory Professor Peter Crack
Peter Crouch laboratory	Head of Laboratory Associate Professor Peter Crouch
Deciphering the mysteries of human brain development	Project Leader Dr Mike Clark
Deciphering the relative contributions of different dendritic cells to killer T cell responses	Project Leader Professor Sammy Bedoui
Defining new roles for the Hippo signalling pathway in skeletal muscle	Research Project Leader Associate Professor Paul Gregorevic
Delbridge & Weeks laboratory: Cardiac Phenomics & Signalling	Head of Laboratory Professor Lea Delbridge Co-Lead of Laboratory Dr Kate Weeks
Delineating how CD4 T cells ‘help’ establishing effective killer T cell responses	Project Leader Professor Sammy Bedoui
Dendritic cell maturation following different microbial stimulation	Project Leader Professor William (Bill) Heath
Design, development and testing of HIV vaccines	Project Leader Professor Damian Purcell
Developing a novel class of therapeutics for muscle wasting and frailty	Research Project Leader Dr Benjamin Parker
Developing innovative animal and cell culture models to study and treat muscular dystrophies	Research Project Leader Associate Professor Paul Gregorevic
Development of autonomic and nociceptive circuits	Project Leaders Professor Janet Keast / Dr Peregrine Osborne
Development of effector regulatory T cells	Project Leader Professor Axel Kallies
Development of new types of antimicrobial agents	Project Leader Professor Roy Robins-Browne
Diabetic cardiomyopathy – an epidemic disease	Research Project Leader Professor Lea Delbridge Dr Kate Weeks
Discovering and characterizing new genes involved in innate immunity, tissue injury and fibrosis	Project Leader Professor Christine Wells
Towards understanding new therapies for obesity and diabetes: discovering new regulators of lipid metabolism	Research Project Leader Professor Matthew Watt
Dodd laboratory: Metabolic Neuroscience	Head of Laboratory A/Prof Garron Dodd
Edgington-Mitchell laboratory: Protease pathophysiology	Head of Research Group A/Prof Laura Edgington-Mitchell
EMT regulators in intestinal and germline stem cells	Project Leader Professor Gary Hime
Enterococcus faecium	Project Leader Professor Ben Howden
Exercise-induced liver-muscle cross-talk and mitochondrial adaptations	Research Project Leader Dr Magdalene Montgomery
Exploring new roles for the TGFβ signalling network as a key regulator of skeletal muscle in health and disease	Research Project Leader Associate Professor Paul Gregorevic
Factors that accelerate photoreceptor death: The role of purines	Head of Laboratory Professor Erica Fletcher
Fletcher laboratory: Visual neuroscience	Head of Laboratory Professor Erica Fletcher
Functional neuroanatomy of genitourinary vasculature	Project Leaders Professor Janet Keast / Dr Peregrine Osborne
Furness laboratory: Digestive physiology and nutrition	Head of Laboratory Professor John Furness
Gebhardt laboratory: Adaptive immune responses to virus infections	Head of Laboratory Professor Thomas Gebhardt
Genetics of blood brain barrier formation	Project Leader Professor Ben Hogan
Ghosal laboratory: In situ structural biology	Head of Laboratory Dr Debnath Ghosal
Gleeson laboratory: Membrane trafficking in the secretory and endocytic pathways in health and disease.	Head of Laboratory Professor Paul Gleeson
Glial cells as a source of progenitor cells in degenerative disease	Head of Laboratory Professor Erica Fletcher
Godfrey laboratory: The development and function of unconventional T cells	Head of Laboratory Professor Dale Godfrey
Gooley laboratory: Receptor structural biology	Head of Laboratory Professor Paul Gooley
Gregorevic laboratory: Muscle Research and Therapeutics	Head of Laboratory Professor Paul Gregorevic
Griffin laboratory: Protein biophysics and structural biology	Head of Laboratory Dr Michael Griffin
Gunnersen laboratory: Neuron development and plasticity	Head of Laboratory Associate Professor Jenny Gunnersen
Haque Laboratory	Head of Laboratory Associate Professor Ashraful Haque
Harnessing local immunity to block the development of secondary bacterial pneumonia	Project Leader Dr Linda Wakim
Hatters laboratory: Molecular mechanisms of neurodegeneration	Head of Laboratory Professor Danny Hatters
Heath laboratory: CD8 T lymphocytes, dendritic cells, self tolerance and immunity	Head of Laboratory Professor William (Bill) Heath
Hime laboratory: Stem cell genetics and Drosophila models of human disease	Head of Laboratory Professor Gary Hime
Hogan laboratory: Vascular Cell and Developmental Biology	Head of Laboratory Professor Ben Hogan
How do dietary nutrients affect the ability of stem cells and stem cell-derived tumours to grow and divide?	Project Leader A/Professor Louise Cheng
How do neural stem cells maintain quiescence?	Project Leader A/Professor Louise Cheng
How do neurons maintain their specialised status?	Project Leader A/Professor Louise Cheng
How do our genes cause neuropsychiatric disorders?	Project Leader Dr Mike Clark
How do tumours compete for resources to grow?	Project Leader A/Professor Louise Cheng
How does GM-CSF prevent brain damage after traumatic injury?	Head of Laboratory Dr Jenny Gunnersen Project Leader Dr Sandy Shultz
How is the immunological T cell memory generated?	Project Leader Associate Professor Katherine Kedzierska
Howden laboratory: Molecular epidemiology, genomics and pathogenesis of antimicrobial resistant bacteria	Head of Laboratory | Director of MDU Professor Ben Howden
Hoyer laboratory: Translational neuropharmacology	Head of Laboratory Professor Daniel Hoyer
Human brain networks processing respiratory sensations	Project Leader Professor Stuart Mazzone
Hypothalamic modulation of basal sympathetic activity	Research Project Leader Professor Andrew Allen
Identifying factors that improve gastrointestinal function in Duchenne's muscular dystrophy	Research Project Leader Professor Gordon Lynch
Identifying the mechanisms of immune cell development in peripheral tissues	Project Leader Professor Laura Mackay
Imaging effector and memory T cell responses in the skin following Herpes Simplex Virus-1 infection	Project Leader Professor William (Bill) Heath
Imaging the priming of CD8 Killer T cell responses to Herpes Simplex Virus-1 skin infection	Project Leader Professor William (Bill) Heath
Improved vaccines by targeting to dendritic cells	Project Leader Professor William (Bill) Heath
Influenza A virus PB1-F2 Protein: a putative virulence factor and initiator of inflammation	Project Leader Dr Julie McAuley
Influenza and HIV vaccines and the importance of mucosal immunity	Project Leader Professor Stephen Kent
Influenza–specific ADCC: Role in a universal flu vaccine?	Project Leader Professor Stephen Kent
Innate immunity and neural injury	Head of Laboratory Associate Professor Peter Crack
Innate T cell recognition and development	Project Leader Dr Daniel Pellicci
Insulin on the Brain	Research Project Leader Dr Garron Dodd
Intraepithelial T cells in anti-viral immunity	Project Leader Professor Francis (Frank) Carbone
Intravital imaging of T cell responses in the brain during cerebral malaria infection	Project Leader Professor William (Bill) Heath
Investigating the Dystrophin-Glycoprotein Complex to Protect Muscles from Wasting Conditions	Research Project Leader Professor Gordon Lynch
Investigating the mechanism of action of the antiviral molecule, IFITM3	Project Leader Dr Linda Wakim
Investigating the role of cachexia in the response to surgical tumour resection in mice	Research Project Leader Professor Gordon Lynch
Investigation of HSV latency and reactivation	Project Leader Professor Francis (Frank) Carbone
Is the “shed” form of Sez-6 proteins responsible for their synapse-promoting effects?	Head of Laboratory Dr Jenny Gunnersen Project Leader Dr Kathryn Munro
Ivanusic laboratory: Pain and sensory mechanisms	Head of Laboratory Professor Jason Ivanusic
Kallies laboratory: Molecular immunology	Head of Laboratory Professor Axel Kallies
Keast-Osborne Laboratory: Neural and Bioelectronic Control of Pelvic Organs	Joint Head of Lab Prof Janet Keast Joint Head of Lab A/Prof Peregrine Osborne
Kedzierska laboratory: Immunity to pandemic and newly emerged influenza viruses	Head of Laboratory Associate Professor Katherine Kedzierska
Keenan laboratory: Epigenetic regulation of immunity and disease	Head of Laboratory Dr Christine Keenan
Kent laboratory: HIV vaccines; immune responses to HIV-1; immunotherapy	Head of Laboratory Professor Stephen Kent
Klebsiella pneumoniae	Project Leader Professor Dick Strugnell
Lawson laboratory: Transmissible neurodegeneration	Head of Laboratory Associate Professor Vicki Lawson
Learning from skeletal muscles to develop new treatments for cancer	Research Project Leader Associate Professor Paul Gregorevic
Live imaging of cellular signalling in vascular development and disease models	Project Leader Professor Ben Hogan
Lung Disease Research Laboratory	Head of Laboratory Professor Gary P Anderson
Lynch laboratory: Basic and clinical myology	Head of Laboratory Professor Gordon Lynch
Mackay laboratory: Tissue-resident memory T cells; lymphocyte differentiation; peripheral immunity	Lab Head, NHMRC Leadership Fellow, Dame Kate Campbell Fellow Professor Laura Mackay FAHMS
Mackenzie laboratory: Intracellular virus replication and innate immunity	Head of Laboratory Professor Jason Mackenzie
MAIT cells in homeostasis and microbial infections	Researchers Dr Zhenjun Chen, Dr Alexandra Corbett and Dr Sidonia Eckle
Malaria and Tissue Resident Memory T cells (TRM) in the liver	Project Leader Professor William (Bill) Heath
Mapping the distribution of angiotensin receptors in the brain	Research Project Leader Professor Andrew Allen
Mature and developing synaptic transmission between defined classes of enteric neurons	Research Project Leader Dr Jaime Foong
Mazzone laboratory: Respiratory Sensory Neuroscience	Head of Research Group Professor Stuart Mazzone
McCluskey laboratory: Role of MAIT cells in health and disease	Head of Laboratory Redmond Barry Distinguished Professor James McCluskey
McDevitt laboratory	Head of Laboratory Associate Professor Christopher McDevitt
McQuade laboratory: Gut-Barrier & Disease	Head of Laboratory Dr Rachel McQuade
Mechanisms of diastolic heart failure	Research Project Leader Professor Lea Delbridge Dr Kate Weeks
Mechanisms underlying early generation of human T cell memory	Project Leader Associate Professor Katherine Kedzierska
Memory T cell responses in the lung during virus infection	Project Leader Dr Linda Wakim
Metabolic reprogramming of skeletal muscle stem cells	Research Project Leader Professor Gordon Lynch
Mintern laboratory: Vaccine and immunotherapy	Head of Laboratory Prof Justine Mintern
Molecular and cellular analysis of mammalian ovary development and disease	Project Leader Associate Professor Dagmar Wilhelm
Molecular mechanisms controlling lymphangiogenesis	Project Leader Professor Ben Hogan
Molecular mechanisms that contribute to skeletal pain	Head of Laboratory Professor Jason Ivanusic
Montgomery laboratory: Metabolic Tissue Cross-Talk	Head of Laboratory Dr Magdalene Montgomery
Murray laboratory: Myelin biology	Head of Laboratory Associate Professor Simon Murray
Muscle wasting in multiple system atrophy	Research Project Leader Professor Gordon Lynch
Mycobacterium ulcerans	Project Leader Professor TIm Stinear
Nanoparticle HIV vaccines	Project Leader Professor Stephen Kent
Nanoparticle Modulation of Mast Cell Function	Project Leader Dr Graham Mackay
Neuroanatomy of human visceral systems	Professor Janet Keast
Neuropsychiatric disorder gene characterisation with Nanopore sequencing	Project Leader Dr Mike Clark
NK cell receptor biology	Project Leader Professor Andrew Brooks
Non-classical MHC and Class 1-like molecules	Project Leader Professor Andrew Brooks
Non-conventional T cells and HIV: role of NKT cells, MAIT cells, CD-1 restricted and gamma-delta T cells	Project Leader Professor Stephen Kent
Norovirus replication and innate immunity	Project Leader Professor Jason Mackenzie
Novel Mast Cell-Derived Mediators	Project Leader Dr Graham Mackay
Oxidative stress and neural injury	Head of Laboratory Associate Professor Peter Crack
Pain management using ultrasound-guided local anaesthetic techniques	Head of Laboratory Professor Jason Ivanusic
Parker laboratory: Metabolic Proteomics & Signal Transduction	Head of Laboratory A/Prof Benjamin Parker
Parker laboratory: Structural biology and computational Design	Head of Laboratory and Director, Bio21 Institute Professor Michael Parker
Passive antibody immunity for use in combination microbicides	Project Leader Professor Damian Purcell
Post-translational control of cell fate decisions	Project Leader Associate Professor Dagmar Wilhelm
Precursor exhausted T cells in chronic infection and tumors	Project Leader Professor Axel Kallies
Prognostic biomarker and therapeutic target discovery in stroke	Project Leader Dr Jonathon Mangum
Project 1. How do CD4+ T cells preserve memories during malaria?	Head of Laboratory Associate Professor Ashraful Haque
Project 1. Should we worry about prion associated heart disease?	Head of Laboratory Associate Professor Vicki Lawson
Project 2. CD4+ T cells in acute Graft-versus-Host Disease	Head of Laboratory Associate Professor Ashraful Haque
Project 2. COVID-19 associated brain injury and inflammation	Head of Laboratory Associate Professor Vicki Lawson
Project 3. Do malaria parasites sense and respond to the host during infection?	Head of Laboratory Associate Professor Ashraful Haque
Purcell laboratory: Viral RNA elements, regulation of HIV replication, HIV antibody vaccine	Head of Laboratory Professor Damian Purcell
Ralph laboratory: Antimalarial targets and resistance	Head of Laboratory Dr Stuart Ralph
Reading laboratory: Innate immune detection and response to respiratory virus infections	Head of Laboratory Associate Professor Patrick Reading
Regulation of Mast Cell Activation	Project Leader Dr Graham Mackay
Resident memory T cells (Trm)	Project Leader Professor Axel Kallies
RNA mediated control of HIV-1 gene expression	Project Leader Professor Damian Purcell
Robins-Browne laboratory: Medical bacteriology, pathogenesis, bacterial genetics, therapeutics	Head of Laboratory Professor Roy Robins-Browne
Role of cellular lipids during Flavivirus replication	Project Leader Professor Jason Mackenzie
Role of innate signals in inducing protective T cell immunity	Project Leader Professor Sammy Bedoui
Ruparelia Laboratory: Muscle Growth, Regeneration and Ageing	Head of Laboratory Dr Avnika Ruparelia
Salmonella Typhimurium	Project Leader Professor Dick Strugnell
Self-tolerance: Interactions between thymic stroma and dendritic cells	Project Leader Professor William (Bill) Heath
Sex, adiposity and cardiac vulnerability	Research Project Leader Professor Lea Delbridge Dr Kate Weeks
Sex-specific regulation of adipose tissue immune cells	Project Leader Professor Axel Kallies
Shakeel laboratory: Structural genome regulation	Lab Head & Principal Research Fellow A/Prof Shabih Shakeel
Skeletal muscle signal transduction related to exercise, metabolic disease and human health	Research Project Leader Dr Benjamin Parker
Smith laboratory: Cardiac Genetics	Head of Laboratory Associate Professor Kelly Smith
Soluble barriers to influenza virus infection	Project Leader Associate Professor Patrick Reading
Solving a Major Complication of Parkinson’s Disease: Targeting Debilitating Constipation Through Novel Pharmacology	Joint Heads of Laboratory Professor John Furness & Dr Myat Noe (Cherish) Han
Staphylococcus aureus & Enterococcus faecium	Project Leader Professor Tim Stinear
Staphylococcus aureus and Staphylococcus epidermidis	Project Leader Professor Ben Howden
Stojanovski laboratory: Mitochondrial biology and disease	Head of Laboratory Professor Diana Stojanovski
Stroke	Head of Laboratory Associate Professor Peter Crack
Stroud laboratory: Rare disease functional genomics	Head of Research Group A/Prof David Stroud
Structure and function of bacterial "cytomotive" filaments	Project Leader Dr Debnath Ghosal
Strugnell laboratory: Bacterial pathogenesis and host responses	Head of Laboratory Professor Dick Strugnell
Systems genetics of muscle metabolism	Research Project Leader Dr Benjamin Parker
T cells in peripheral immunity	Project Leader Professor Francis (Frank) Carbone
The Bonn and Melbourne Research and Graduate School	Melbourne Coordinator Dr Marie Greyer
The Enteric Neural Circuitry Activated During Bacterial-toxin Induced Diarrhoea	Research Project Leader Dr Jaime Foong
The heart as a central player in tissue cross-talk	Research Project Leader Dr Magdalene Montgomery
The mechanisms of viral escape in murine and human influenza infection	Project Leader Associate Professor Katherine Kedzierska
The role of CD4+ T cells in viral infections	Project Leader Professor Andrew Brooks
The Role of enteric neurons in gastrointestinal symptoms associated with Autism Spectrum disorders	Research Project Leader Dr Elisa Hill-Yardin
The role of glia in inner retinal changes during retinal degeneration	Head of Laboratory Professor Erica Fletcher
The role of glial cells in retinal vascular disease	Head of Laboratory Professor Erica Fletcher
The role of innate immune cells in protection and pathology during influenza virus infection	Project Leader Associate Professor Patrick Reading
The role of microglia in age-related macular degeneration	Head of Laboratory Professor Erica Fletcher
The role of protein modifications on muscle development	Research Project Leader Dr Benjamin Parker
The role of the prorenin receptor in male and female fertility	Project Leader Associate Professor Dagmar Wilhelm
The role of tissue-resident memory T cells in barrier immunity, cancer and autoimmune diseases	Project Leader Professor Laura Mackay
The roles of metal ions in host-pathogen interaction	Research Project Leader Associate Professor Christopher McDevitt
Therapeutic potential of skeletal muscle plasticity and slow muscle programming for muscular dystrophy	Research Project Leader Professor Gordon Lynch
Tissue communication in non-alcoholic fatty liver disease (NALFD) and liver fibrosis	Research Project Leader Dr Magdalene Montgomery
Tracking phenotypically and functionally distinct T cell subsets via T cell repertoire diversity	Project Leader Associate Professor Katherine Kedzierska
Transcriptional profiling of sensory neurons	Project Leader Professor Stuart Mazzone
Transcriptional reprogramming of metabolism in liver cancer	Project Leader Dr Andrew Cox
Traumatic brain injury	Head of Laboratory Associate Professor Peter Crack
Uncovering the interplay between innate immunity and the blood brain barrier in disorders of the CNS	Project Leader Professor Christine Wells
Understanding how metal ions traverse bacterial cell membranes	Research Project Leader Associate Professor Christopher McDevitt
Understanding metabolic cross-talk in health and disease - Focus on type 2 diabetes and fatty liver	Research Project Leader Dr Magdalene Montgomery
Understanding the aetiology of hypertension	Research Project Leader Professor Andrew Allen
Understanding the fate decisions that govern memory T cell development	Project Leader Professor Laura Mackay
Understanding the interaction between microbiota and T cell immunity	Project Leader Professor Sammy Bedoui
Understanding the role of angiotensin in the rostral ventrolateral medulla	Research Project Leader Professor Andrew Allen
Understanding ‘universal’ influenza-specific CD8+ T cell responses	Project Leader Associate Professor Katherine Kedzierska
Unravelling the mysteries of E3 ubiquitin ligase in regulating skeletal muscle size and function	Research Project Leader Associate Professor Paul Gregorevic
Vaccination against liver-stage Plasmodium for malaria prevention	Project Leader Professor William (Bill) Heath
Villadangos laboratory: Immunology and cell biology	Head of Laboratory Professor Jose Villadangos
Viral interactions with the innate immune system	Project Leader Associate Professor Patrick Reading
Visualization and formation West Nile Virus replication complexes	Project Leader Professor Jason Mackenzie
Wakim laboratory: Antiviral molecules, mucosal immunology, influenza virus, tissue resident memory T cells	Head of Laboratory Dr Linda Wakim
Watt laboratory: Metabolism and Diabetes	Head of Laboratory Professor Matthew Watt
West Nile Virus replication and cellular stress responses	Project Leader Professor Jason Mackenzie
What is the function of Sez6L2 in the forebrain?	Head of Laboratory Dr Jenny Gunnersen Project Leader Dr Kathryn Munro
Whole body analysis of human T cell development and function	Project Leader Professor Laura Mackay
Wilhelm laboratory: Gonad Development and Fertility	Head of Laboratory Associate Professor Dagmar Wilhelm

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