Viral interactions with the innate immune system

Project Details

Our research is also directed towards understanding how viruses evolve to evade innate immune defenses and therefore induce disease, with particular focus on influenza virus. We have analysed the glycosylation patterns and sialic acid preferences of different influenza strains and the juxtaposition between their decreased susceptibility to antibody-mediated immunity and increased susceptibility to soluble innate factors of the immune system. In addition we are investigating the entry requirements of influenza virus, examining the mechanisms by which C-type lectin receptors and other internalisation receptors facilitate infection. We aim to exploit these mechanisms and defenses to generate novel intervention strategies that can be used to alleviate severe disease. For further information see: A/Prof Patrick Reading.

photomicrograph showing Lec2-Langerin cells stained with Langerin (green), clatherin (red) and DAPI (blue)

Figure 1: Lec2-Langerin cells stained with Langerin (green), clatherin (red) and DAPI (blue).

Research Group

Brooks laboratory: Innate immunity; anti-viral immunity

Faculty Research Themes

Infection and Immunology

School Research Themes

Molecular Mechanisms of Disease

Key Contact

For further information about this research, please contact the research group leader.

Department / Centre

Microbiology and Immunology

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