Mechanisms underlying early generation of human T cell memory

Project Details

Though immunological memory is of pivotal importance for vaccine development and immunotherapy, the molecular and differentiation pathways central to the generation of (particularly) human CD8+ T-cell memory are poorly understood. Here, we aim to:

  1. establish the key factors driving the early establishment of influenza-specific T cell memory;
  2. To define molecular processes involved in CD27-mediated co-stimulation of human T cells. As memory is crucial for protection against recurrent infections, this work will provide novel insights into the generation and efficacy of human T cell memory populations and inform effective CD27-mediated stimulation for immunotherapy.

Research Group

Kedzierska laboratory: Immunity to pandemic and newly emerged influenza viruses


Faculty Research Themes

Infection and Immunology

School Research Themes

Molecular Mechanisms of Disease


Key Contact

For further information about this research, please contact the research group leader.

Department / Centre

Microbiology and Immunology

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