Autophagy and Norovirus replication
Professor Jason Mackenzie
+61 3 9035 8376
We are also interested in the role autophagy plays in MNV-1 replication. Autophagy is a cellular mechanism used to recycle proteins and degrade pathogens as a method of prolonging cell life. We have since discovered that MNV-1 infection induces autophagy but does not utilize the autophagosomal membranes to facilitate replication. Various techniques have been used in this project including; immunofluorescence, western blotting, qPCR, plaque assays and live cell imaging. Further analyses will examine the effects of autophagy inducing and inhibiting compounds on MNV-1 replication and what implications these results will reveal about how MNV-1 is able to manipulate cells.
Ms Tanya O'Donnell (PhD student)
Justine Mintern (University of Melbourne) and Skip Virgin (Washington University School of Medicine, USA)
Mackenzie laboratory: Intracellular virus replication and innate immunity
Faculty Research Themes
School Research Themes
Molecular Mechanisms of Disease
For further information about this research, please contact the research group leader.
Department / Centre
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