Autophagy and Norovirus replication

Project Details

We are also interested in the role autophagy plays in MNV-1 replication. Autophagy is a cellular mechanism used to recycle proteins and degrade pathogens as a method of prolonging cell life. We have since discovered that MNV-1 infection induces autophagy but does not utilize the autophagosomal membranes to facilitate replication. Various techniques have been used in this project including; immunofluorescence, western blotting, qPCR, plaque assays and live cell imaging. Further analyses will examine the effects of autophagy inducing and inhibiting compounds on MNV-1 replication and what implications these results will reveal about how MNV-1 is able to manipulate cells.

Researchers

Ms Tanya O'Donnell (PhD student)

Collaborators

Justine Mintern (University of Melbourne) and Skip Virgin (Washington University School of Medicine, USA)

Research Group

Mackenzie laboratory: Intracellular virus replication and innate immunity


Faculty Research Themes

School Research Themes

Molecular Mechanisms of Disease


Key Contact

For further information about this research, please contact the research group leader.

Department / Centre

Microbiology and Immunology

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