Scott Laboratory: Microbial glycoproteomics and host pathogen interactions

Research Overview

View a comprehensive listing of Dr Nichollas Scott's research publications here.

The Scott lab focuses on understanding microbial glycosylation systems as well as the link between glycosylation and virulence. Through the addition of carbohydrates to proteins, a process known as protein glycosylation, microbes are able to radically alter the function of proteins. Within a range of infections such as Malaria, Gonorrhoea and Salmonella, microbial protein glycosylation is used for both defensive and offensive processes; enabling pathogens to fortify themselves against the host immune response or to disarm the host’s ability to resist infection. By better understanding these systems the Scott laboratory aims to provide new insight into the mechanisms of pathogenesis of life-threatening infections such as those caused by Burkholderia species. To achieve this, our work focuses on developing and applying new methodologies to monitor glycosylated and non-glycosylated proteins using proteomics and mass spectrometry.

Image 1: Diagrammatic representation of the OGC cluster and O-linked glycosylation system.

Staff

Dr Jessica Lewis, Postdoctoral Researcher

Dr Pauline M.L. Coulon, Postdoctoral Researcher

Collaborators

Associate Professor Hayley Newton, Department of Microbiology and Immunology, The University of Melbourne

Professor Elizabeth Hartland, Hudson Institute of Medical Research

Associate Professor Justin Boddey, The Walter and Eliza Hall Institute of Medical Research

Associate Professor Ethan Goddard-Borger, The Walter and Eliza Hall Institute of Medical Research

Dr Mitali Sarkar-Tyson, The University of Western Australia

Associate Professor Mario Feldman, Washington University St. Louis

Professor Miguel Valvano, Queen's University Belfast

Funding

2021-2024 ARC Future Fellowship. (FT200100270). Awarded $850,770.00 with an additional $150,000 from the University of Melbourne

2021-2023  ARC Discovery Project Grant. (DP210100362). Awarded $534,500.00

Research Opportunities

This research project is available to PhD students, Masters by Research, Honours students to join as part of their thesis.
Please contact the Research Group Leader to discuss your options.

Research Projects

This Research Group doesn't currently have any projects



Faculty Research Themes

School Research Themes

Infection & Immunity, Systems Biology



Key Contact

For further information about this research, please contact Head of Laboratory Dr Nichollas Scott

Department / Centre

Microbiology and Immunology

Unit / Centre

Scott Laboratory: Microbial glycoproteomics and host pathogen interactions

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