Scott Laboratory: Microbial glycoproteomics and host pathogen interactions

The Scott lab focuses on understanding microbial glycosylation systems as well as the link between glycosylation and virulence. Through the addition of carbohydrates to proteins, a process known as protein glycosylation, microbes are able to radically alter the function of proteins. Within a range of infections such as Malaria, Gonorrhoea and Salmonella, microbial protein glycosylation is used for both defensive and offensive processes; enabling pathogens to fortify themselves against the host immune response or to disarm the host’s ability to resist infection. By better understanding these systems the Scott laboratory aims to provide new insight into the mechanisms of pathogenesis of life-threatening infections such as those caused by Burkholderia species. To achieve this, our work focuses on developing and applying new methodologies to monitor glycosylated and non-glycosylated proteins using proteomics and mass spectrometry.

Dr Jessica Lewis, Postdoctoral Researcher

Dr Pauline M.L. Coulon, Postdoctoral Researcher

Associate Professor Hayley Newton, Department of Microbiology and Immunology, The University of Melbourne

Professor Elizabeth Hartland, Hudson Institute of Medical Research

Associate Professor Justin Boddey, The Walter and Eliza Hall Institute of Medical Research

Associate Professor Ethan Goddard-Borger, The Walter and Eliza Hall Institute of Medical Research

Associate Professor Mario Feldman, Washington University St. Louis

Professor Miguel Valvano, Queen's University Belfast