Godfrey laboratory: The development and function of unconventional T cells
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Professor Dale Godfrey+61 3 8344 6831
Research Overview
The laboratory is interested in understanding the development and function of Innate like T cells. These include: CD1d restricted NKT cells; CD1a, CD1b and CD1c restricted T cells; MR1 restricted MAIT cells; and gamma-delta T cells. Collectively, these cells represent a high proportion of the immune system and they have a potent ability to modulate immune responses to infections, cancer, allergens and self-tissue. There are 7 major research themes in the laboratory.
Major Research Themes:
- Innate-like T cell development and homeostasis
- Innate like T cell subsets and their functional diversity
- Antigen recognition by innate-like T cell receptors
- The role of innate-like T cells in tumour immunity
- The role of innate-like T cells in autoimmunity
- The role of innate-like T cells in allergy
- The role of innate-like T cells in infection.
Staff
Research Officers
Dr Catarina Almeida
Dr Garth Cameron
Dr Thomas Fulford
Dr Nicholas Gherardin
Dr Hui-Fern Koay
Mr Keit Loi
Dr Adam Uldrich
Research Assistants
Mr Marcin Ciula
Ms Katherine Gourley
Mr Samuel Redmond
Mr Zheng Ruan
Ms Rebecca Seneviratna
Laboratory Coordinator
Mr Marcin Ciula (0.6)
PhD Graduate Researchers
Ms Hui-Fern Koay
Mr Shihan "Tony" Li
Ms Catriona Nguyen-Robertson
Mr Calvin Xu
Funding
Current Grants
2012-2016: NHMRC program grant (#1013667) – Immune regulation, effector function and therapy.
Co-chief investigators: Joe Trapani, Mark Smyth, Ricky Johnstone, Dale Godfrey, Miles Prince, Michael Kershaw.
Total $2500000 p.a. DG share = $450000 p.a.
2012-2016: NHMRC Senior Principal Research Fellowship (#1020770).
Dale Godfrey.
$800K $158972 p.a.
2013-2015: A*Star-NHMRC joint grant funding Project Grant. APP1056277. Harnessing lipid-reactive immunity to combat Mycobacterium tuberculosis infection.
J Rossjohn, L Mori, D Godfrey, G DeLibero.
$330K
2013-2015:Cancer Council Victoria. J Rossjohn, D Godfrey. APP1042866. A structural and functional investigation into tumour recognition by NKT cells.
$300K
2014-2016:ARC Discovery Project. D Godfrey. APP DP140100977. Gamma delta T cells specific for glycolipid antigens.
$500K.
2014-2020:ARC Centre of Excellence in Advanced Molecular Imaging.
CIs J Whisstock, J Rossjohn, W Heath, H Quiney, K Nugent, D Godfrey, B Abbey, D Fairlie, K Gaus, A Peele, J Davey, H Chapman.
$40 million over 7 years.
Research Projects
Faculty Research Themes
School Research Themes
Molecular Mechanisms of Disease
Key Contact
For further information about this research, please contact Head of Laboratory Professor Dale Godfrey
Department / Centre
Unit / Centre
Godfrey laboratory: The development and function of unconventional T cells
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