Godfrey laboratory: The development and function of unconventional T cells

Research Overview

The laboratory is interested in understanding the development and function of Innate like T cells. These include: CD1d restricted NKT cells; CD1a, CD1b and CD1c restricted T cells; MR1 restricted MAIT cells; and gamma-delta T cells.  Collectively, these cells represent a high proportion of the immune system and they have a potent ability to modulate immune responses to infections, cancer, allergens and self-tissue. There are 7 major research themes in the laboratory.

Major Research Themes:

  1. Innate-like T cell development and homeostasis
  2. Innate like T cell subsets and their functional diversity
  3. Antigen recognition by innate-like T cell receptors
  4. The role of innate-like T cells in tumour immunity
  5. The role of innate-like T cells in autoimmunity
  6. The role of innate-like T cells in allergy
  7. The role of innate-like T cells in infection.


Research Officers

Dr Catarina Almeida
Dr Garth Cameron
Dr Thomas Fulford
Dr Nicholas Gherardin
Dr Hui-Fern Koay
Mr Keit Loi
Dr Adam Uldrich

Research Assistants

Mr Marcin Ciula
Ms Katherine Gourley
Mr Samuel Redmond
Mr Zheng Ruan
Ms Rebecca Seneviratna

Laboratory Coordinator

Mr Marcin Ciula (0.6)

PhD Graduate Researchers

Ms Hui-Fern Koay
Mr Shihan "Tony" Li
Ms Catriona Nguyen-Robertson
Mr Calvin Xu


Current Grants

2012-2016: NHMRC program grant (#1013667) – Immune regulation, effector function and therapy.
Co-chief investigators: Joe Trapani, Mark Smyth, Ricky Johnstone, Dale Godfrey, Miles Prince, Michael Kershaw.
Total $2500000 p.a. DG share = $450000 p.a.

2012-2016: NHMRC Senior Principal Research Fellowship (#1020770).
Dale Godfrey.
$800K $158972 p.a.

2013-2015: A*Star-NHMRC joint grant funding Project Grant. APP1056277. Harnessing lipid-reactive immunity to combat Mycobacterium tuberculosis infection.
J Rossjohn, L Mori, D Godfrey, G DeLibero.

2013-2015:Cancer Council Victoria. J Rossjohn, D Godfrey. APP1042866. A structural and functional investigation into tumour recognition by NKT cells.

2014-2016:ARC Discovery Project. D Godfrey. APP DP140100977. Gamma delta T cells specific for glycolipid antigens.

2014-2020:ARC Centre of Excellence in Advanced Molecular Imaging.
CIs J Whisstock, J Rossjohn, W Heath, H Quiney, K Nugent, D Godfrey, B Abbey, D Fairlie, K Gaus, A Peele, J Davey, H Chapman.
$40 million over 7 years.

Research Projects

Faculty Research Themes

Infection and Immunology

School Research Themes

Molecular Mechanisms of Disease

Key Contact

For further information about this research, please contact Head of Laboratory Professor Dale Godfrey

Department / Centre

Microbiology and Immunology

Unit / Centre

Godfrey laboratory: The development and function of unconventional T cells

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