Leann Tilley laboratory

Research Overview

As part of her Australian Laureate Fellowship Program, with funding from the Australian Research Council, Professor Tilley created the Georgina Sweet Award for Women in Quantitative Bioscience. For further details:

Georgina Sweet Laureate Professorship

Malaria parasite-infected erythrocytes

Every minute, one child in Africa dies from malaria. Around the world, the mosquito-borne parasite kills about 450,000 people each year, most of them children and pregnant women, while another 200 million people suffer illness as a result of malaria infections.

Carried by the Anopheles mosquito, the tiny malaria parasite invades the victim's red blood cells where it starts devouring the red cell haemoglobin and changing the cells so that the infected red blood cells stick to blood vessel walls. This leads to the typical symptoms of fever and headaches, but in severe cases results in coma and death.

electron tomography of the malaria parasite Electron tomography of the malaria parasite, P. falciparum. The rendered models show different stages of development of the parasite in its host, a red blood cell.

The Tilley lab is working as part of a global effort to understand and control malaria. We undertake research in the areas of cell biology and drug development related to the malaria parasite, Plasmodium falciparum. We are particularly interested in in designing antimalarial drugs, based on inhibition of protein translation. We are interested in how the parasite alters the erythrocyte surface to cause malaria pathology, as well as the remarkable transformation that turns parasites banana-shaped and allows them to be transmitted from a human host to a mosquito vector.


Postdoctoral Fellows

Stanley (Cheng) Xie
Gerry Shami
Con Dogovski
Elyse Dunn

Lab Co-ordinator

Shannon Kenny Williams

Research Assistants

Daniel Barry
Tanya Puhalovich

Graduate Students

Jiahong Li
Olivia Carmo
Mohini Shibu
Chia-Wei Tai
Nutpakal Ketprasit

Honours Students

Mona Amini

Research Publications

Click here for the results of a PubMed search of Leann's publications
Click here for the results of a Google Scholar analysis of Leann's publications

Research Projects

Faculty Research Themes

Infection and Immunology

School Research Themes

Cellular Imaging & Structural Biology, Therapeutics & Translation

Key Contact

For further information about this research, please contact Head of Laboratory, Redmond Barry Distinguished Professor of Biochemistry & Pharmacology, ARC Australian Laureate Fellow (2015-2020) Professor Leann Tilley

Department / Centre

Biochemistry and Pharmacology

Unit / Centre

Leann Tilley laboratory

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