Understanding ‘universal’ influenza-specific CD8+ T cell responses

Project Details

Although CD8+ T-cells confer universal immunity to distinct influenza viruses and may limit influenza-induced mortality, the overall efficacy of human influenza A virus-specific CD8+ T cells directed at any conserved and/or variable epitopes remains unclear. Here, we aim to:

  1. understand influenza-specific CD8+ T-cell immunity across different HLAs;
  2. determine the efficacy of immunodominant CD8+ T-cell responses in humans;
  3. evaluate the conservation of immunogenic epitopes in birds, pigs and humans through analysis of viral evolutionary history (with A/Prof Vijaykrishna; Duke-NUS, Singapore);
  4. understand immunity to clinically important but understudied influenza B viruses.

Research Group

Kedzierska laboratory: Immunity to pandemic and newly emerged influenza viruses

Faculty Research Themes

Infection and Immunology

School Research Themes

Infection & Immunity, Molecular Mechanisms of Disease

Key Contact

For further information about this research, please contact the research group leader.

Department / Centre

Microbiology and Immunology

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