Understanding ‘universal’ influenza-specific CD8+ T cell responses

Project Details

Although CD8+ T-cells confer universal immunity to distinct influenza viruses and may limit influenza-induced mortality, the overall efficacy of human influenza A virus-specific CD8+ T cells directed at any conserved and/or variable epitopes remains unclear. Here, we aim to:

  1. understand influenza-specific CD8+ T-cell immunity across different HLAs;
  2. determine the efficacy of immunodominant CD8+ T-cell responses in humans;
  3. evaluate the conservation of immunogenic epitopes in birds, pigs and humans through analysis of viral evolutionary history (with A/Prof Vijaykrishna; Duke-NUS, Singapore);
  4. understand immunity to clinically important but understudied influenza B viruses.

Research Group

Kedzierska laboratory: Immunity to pandemic and newly emerged influenza viruses

Faculty Research Themes

Infection and Immunology

School Research Themes

Molecular Mechanisms of Disease

Key Contact

For further information about this research, please contact the research group leader.

Department / Centre

Microbiology and Immunology

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