Defining new roles for the Hippo signalling pathway in skeletal muscle
Associate Professor Paul Gregorevic
+61 3 9035 7700
The Hippo signalling pathway regulates skeletal muscle stem cell proliferation and terminal differentiation. Recently it has been determined that this pathway also operates as a vital post-natal regulator of the size of skeletal muscle fibres. How the Hippo pathway regulates muscle size, and what regulates the Hippo pathway in adult muscle fibres remains unknown.
This research program is using innovative gene therapy-based technologies to manipulate the Hippo pathway in vitro and in vivo to define (a) the critical targets genes controlled by Hippo signalling in skeletal muscle and (b) the essential elements that regulate Hippo pathway activity to control aspects of skeletal muscle biology.
A/Prof Paul Gregorevic, Head of Laboratory
Dr Kevin Watt, Research Fellow
This research project is available to Honours students to join as part of their thesis.
Please contact the Research Group Leader to discuss your options.
View A/Professor Gregorevic's latest PubMed publications listing here
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