Infection & Immunity

Research in the School is focussed on mechanisms of infection and immunity and the development of new ways to control and treat infectious diseases. Current research programs include the molecular analysis of bacterial and viral infections as well as understanding the development and function of the immune system.

Groups / Projects Research Lead Dept / Centre
"Clock-off time" for inflammation and remodelling in chronic inflammatory diseases: casein kinase inhibitors Primary Supervisor Professor Alastair Stewart Pharmacology and Therapeutics
A new function of the cytokine BAFF in dendritic cell maturation: Implications for immunity and cancers Senior Research Officer & Lab Manager Catherine Kennedy, PhD Microbiology and Immunology
A novel link between metabolism and host defence: O-GlcNAc glycosylation Professor Jose Villadangos Biochemistry and Molecular Biology
A universal vaccine against influenza A Project Leader Professor David Jackson Microbiology and Immunology
Alternative splicing in human parasites Stuart Ralph Biochemistry and Molecular Biology
Analysing protein structures Dr David Ascher Biochemistry and Molecular Biology
Antibody dependent cellular cytotoxicity - a neglected anti-HIV iImmune response! Project Leaders Professor Stephen Kent & Dr Amy Chung Microbiology and Immunology
Antimicrobial resistant bacterial pathogens Project Leader Professor Ben Howden Microbiology and Immunology
Application of genomics to public health and clinical microbiology Project Leader Professor Ben Howden Microbiology and Immunology
Ascher laboratory: Structural biology and bioinformatics Head of Laboratory Dr David Ascher
Biochemistry and Molecular Biology
Australian bite and sting trends: Australian Venomous Injury Project (AVIP) Project Leader Dr Ronelle Welton Pharmacology and Therapeutics
Australian Venom Research Unit Head of Unit Dr David Williams
Pharmacology and Therapeutics
Autophagy and Norovirus replication Professor Jason Mackenzie Microbiology and Immunology
Biolpolymer-based vaccine delivery systems Project Leader Professor David Jackson Microbiology and Immunology
Bo&MeRanG Research Projects Melbourne Coordinator Dr Marie Greyer
Bogoyevitch laboratory: Regulatory biology Head of Laboratory Associate Professor Marie Bogoyevitch
Biochemistry and Molecular Biology
Brooks laboratory: Innate immunity; anti-viral immunity Head of Laboratory Professor Andrew Brooks
Microbiology and Immunology
Brown laboratory: Immunology; virology; vaccinology Head of Laboratory Professor Lorena (Lori) Brown
Microbiology and Immunology
Carbone laboratory: Immune response to herpes simplex virus Head of Laboratory Professor Francis (Frank) Carbone
Microbiology and Immunology
Cell surface receptors for attachment and entry of influenza virus into cells of the innate immune system Project Leader Associate Professor Patrick Reading Microbiology and Immunology
Characterisation of the changes of the endocytic and secretory pathway of dendritic cells upon activation Associate Professor Isabelle Rouiller Biochemistry and Molecular Biology
Chronic immune activation during treated HIV disease Project Leader Professor Damian Purcell Microbiology and Immunology
Correlates of severe and fatal influenza disease in high-risk groups Head of Laboratory Associate Professor Katherine Kedzierska Microbiology and Immunology
Crack laboratory: Neuropharmacology Head of Laboratory Associate Professor Peter Crack
Pharmacology and Therapeutics
Deciphering the relative contributions of different dendritic cells to killer T cell responses Project Leader Associate Professor Sammy Bedoui Microbiology and Immunology
Decoding the trafficking of immune receptors Dr Justine Mintern Biochemistry and Molecular Biology
Delineating how CD4 T cells ‘help’ establishing effective killer T cell responses Project Leader Associate Professor Sammy Bedoui Microbiology and Immunology
Dendritic cell maturation following different microbial stimulation Project Leader Professor William (Bill) Heath Microbiology and Immunology
Design, development and testing of HIV vaccines Project Leader Professor Damian Purcell Microbiology and Immunology
Designing better drugs Dr David Ascher Biochemistry and Molecular Biology
Designing new optogenetic tools for biomedical research A/Prof Danny Hatters Biochemistry and Molecular Biology
Developing a novel class of therapeutics for muscle wasting and frailty Research Project Leader Dr Benjamin Parker
Physiology
Developing new therapies for Systemic Lupus Erythematosus Senior Research Officer & Lab Manager Catherine Kennedy, PhD Microbiology and Immunology
Development and application of soft culturing microenvironment for novel drug discovery Primary Supervisor Professor Alastair Stewart Pharmacology and Therapeutics
Development and application of soft culturing microenvironment for novel drug discovery Professor Alastair Stewart Pharmacology and Therapeutics
Development of a self-adjuvanting vaccine for enterotoxigenic Escherichia coli (ETEC) Project Leader Professor David Jackson Microbiology and Immunology
Development of new types of antimicrobial agents Project Leader Professor Roy Robins-Browne Microbiology and Immunology
Development of Novel antimalarial drugs Professor Leann Tilley Biochemistry and Molecular Biology
Discovering and characterizing new genes involved in innate immunity, tissue injury and fibrosis Project Leader Professor Christine Wells Anatomy and Neuroscience
Edgington-Mitchell laboratory: Protease Pathophysiology Head of Research Group Dr Laura Edgington-Mitchell
Biochemistry and Molecular Biology
Enterococcus faecium Project Leader Professor Ben Howden Microbiology and Immunology
Exploiting nanoparticles as vaccines Dr Justine Mintern Biochemistry and Molecular Biology
Finding clarity within a blizzard- guiding the solution of cryo-EM structures Dr David Ascher Biochemistry and Molecular Biology
Furness laboratory: Digestive physiology and nutrition Head of Laboratory Professor John Furness
Anatomy and Neuroscience
Gebhardt laboratory: Adaptive immune responses to virus infections Head of Laboratory Associate Professor Thomas Gebhardt
Microbiology and Immunology
Gleeson laboratory: Membrane trafficking and protein sorting in health and disease and development of new therapeutics Head of Laboratory Professor Paul Gleeson
Biochemistry and Molecular Biology
Glucocorticoid responsiveness in the lung: impact of inflammation and infection Professor Alastair Stewart Pharmacology and Therapeutics
Glucocorticoid responsiveness in the lung: impact of inflammation and infection Primary Supervisor Professor Alastair Stewart Pharmacology and Therapeutics
Godfrey laboratory: The development and function of unconventional T cells Head of Laboratory Professor Dale Godfrey
Microbiology and Immunology
Gooley laboratory: Structural biology of disease Head of Laboratory Associate Professor Paul Gooley
Biochemistry and Molecular Biology
Gut health: an intersection of food, environment, animal production and global health Project Supervisor Professor John B Furness Anatomy and Neuroscience
Harrap laboratory: Genetic physiology Head of Laboratory Professor Stephen Harrap
Physiology
Heat Shock Protein therapy for muscle wasting Research Project Leader Professor Gordon Lynch
Physiology
Heath laboratory: CD8 T lymphocytes, dendritic cells, self tolerance and immunity Head of Laboratory Professor William (Bill) Heath
Microbiology and Immunology
High fat diets, gut health and diabetes Project Supervisor Dr Rachel McQuade Anatomy and Neuroscience
How infection and trauma cause dendritic cell paralysis and lethal immunosuppression Professor Jose Villadangos Microbiology and Immunology
How is the immunological T cell memory generated? Project Leader Associate Professor Katherine Kedzierska Microbiology and Immunology
How to harness the immune system to cure cancer: adoptive cell immunotherapy Professor Jose Villadangos Microbiology and Immunology
Howden laboratory: Molecular epidemiology, genomics and pathogenesis of antimicrobial resistant bacteria Head of Laboratory | Director of MDU Professor Ben Howden
Microbiology and Immunology
Identifying the mechanisms of immune cell development in peripheral tissues Project Leader Dr Laura Mackay Microbiology and Immunology
Imaging effector and memory T cell responses in the skin following Herpes Simplex Virus-1 infection Project Leader Professor William (Bill) Heath Microbiology and Immunology
Imaging the priming of CD8 Killer T cell responses to Herpes Simplex Virus-1 skin infection Project Leader Professor William (Bill) Heath Microbiology and Immunology
Immunoregulatory functions of the MARCH family of ubiquitin ligases Professor Jose Villadangos Biochemistry and Molecular Biology
Improved vaccines by targeting to dendritic cells Project Leader Professor William (Bill) Heath Microbiology and Immunology
Influenza A virus PB1-F2 Protein: a putative virulence factor and initiator of inflammation Project Leader Dr Julie McAuley Microbiology and Immunology
Influenza and HIV vaccines and the importance of mucosal immunity Project Leader Professor Stephen Kent Microbiology and Immunology
Influenza–specific ADCC: Role in a universal flu vaccine? Project Leader Professor Stephen Kent Microbiology and Immunology
Innate T cell recognition and development Project Leader Dr Daniel Pellicci Microbiology and Immunology
Innovative approaches to prepare synthetic, partially synthetic and natural product-based vaccines Project Leader Professor David Jackson Microbiology and Immunology
Intraepithelial T cells in anti-viral immunity Project Leader Professor Francis (Frank) Carbone Microbiology and Immunology
Intravital imaging of T cell responses in the brain during cerebral malaria infection Project Leader Professor William (Bill) Heath Microbiology and Immunology
Investigation of HSV latency and reactivation Project Leader Professor Francis (Frank) Carbone Microbiology and Immunology
Jackson laboratory: Synthetic vaccine design Head of Laboratory Professor David Jackson
Microbiology and Immunology
Kedzierska laboratory: Immunity to pandemic and newly emerged influenza viruses Head of Laboratory Associate Professor Katherine Kedzierska
Microbiology and Immunology
Kent laboratory: HIV vaccines; immune responses to HIV-1; immunotherapy Head of Laboratory Professor Stephen Kent
Microbiology and Immunology
Klebsiella pneumoniae Project Leader Professor Dick Strugnell Microbiology and Immunology
Koopman laboratory: Clinical nutrition and muscle metabolism Head of Laboratory Dr René Koopman
Physiology
Lawson laboratory: Neurodegenerative disease caused by prions Head of Laboratory Associate Professor Vicki Lawson
Microbiology and Immunology
Lew laboratory: Theoretical and empirical pharmacology Head of Laboratory Dr Michael Lew
Pharmacology and Therapeutics
Lipopeptide-based adjuvanting systems Project Leader Professor David Jackson Microbiology and Immunology
Lung Disease Research Laboratory Head of Laboratory Professor Gary P Anderson Pharmacology and Therapeutics
Lung Health Research Centre Pharmacology and Therapeutics
Lymphoid stromal cell responses to infection Project Leader Associate Professor Scott Mueller Microbiology and Immunology
Mackay (F) laboratory: B lymphocytes, BAFF, autoimmunity and cancer Head of Laboratory
Head of School of Biomedical Sciences Professor Fabienne Mackay

Microbiology and Immunology
Mackay (L) laboratory: Tissue-resident memory T cells; lymphocyte differentiation; peripheral immunity Senior Lecturer & NHMRC Career Development Fellow, HHMI-Gates International Research Scholar Dr Laura Mackay
Microbiology and Immunology
Mackenzie laboratory: Intracellular virus replication and innate immunity Head of Laboratory Professor Jason Mackenzie
Microbiology and Immunology
MAIT cells in homeostasis and microbial infections Researchers Dr Zhenjun Chen, Dr Alexandra Corbett and Dr Sidonia Eckle
Microbiology and Immunology Research
Malaria and Tissue Resident Memory T cells (TRM) in the liver Project Leader Professor William (Bill) Heath Microbiology and Immunology
Malaria parasite-infected red blood cells: a renovator’s dream Professor Leann Tilley Biochemistry and Molecular Biology
Manipulating immunity to fight infection and tumours Dr Justine Mintern Biochemistry and Molecular Biology
McCluskey laboratory: Role of MAIT cells in health and disease Head of Laboratory Redmond Barry Distinguished Professor James McCluskey
Microbiology and Immunology
McConville laboratory: Molecular microbiology Head of Laboratory Professor Malcolm McConville
Biochemistry and Molecular Biology
Mechanisms underlying early generation of human T cell memory Project Leader Associate Professor Katherine Kedzierska Microbiology and Immunology
Memory T cell responses in the lung during virus infection Project Leader Dr Linda Wakim Microbiology and Immunology
Mintern laboratory: Vaccine biology Head of Laboratory Dr Justine Mintern
Biochemistry and Molecular Biology
Modulation of intestinal inflammation through nerve stimulation Project Supervisor Dr Martin Stebbing Anatomy and Neuroscience
MR1 – a molecular alarm system that detects pathogen metabolites Professor Jose Villadangos Microbiology and Immunology
Munsie laboratory: Ethical, legal and social implications of stem cell research Head of Laboratory Associate Professor Megan Munsie
Anatomy and Neuroscience
Mycobacterium ulcerans Project Leader Professor TIm Stinear Microbiology and Immunology
Nanoparticle Modulation of Mast Cell Function Project Leader Dr Graham Mackay
Pharmacology and Therapeutics
Nerve pathways responding to and controlling inflammation in the intestine Project Supervisor Dr Martin Stebbing Anatomy and Neuroscience
Nervous regulation of T cell migration and anti-viral Immunity Project Leader Associate Professor Scott Mueller Microbiology and Immunology
Newton laboratory: Virulence strategies of intracellular bacterial pathogens Head of Laboratory Dr Hayley Newton
Microbiology and Immunology
NK cell receptor biology Project Leader Professor Andrew Brooks Microbiology and Immunology
Non-classical MHC and Class 1-like molecules Project Leader Professor Andrew Brooks Microbiology and Immunology
Non-conventional T cells and HIV: role of NKT cells, MAIT cells, CD-1 restricted and gamma-delta T cells Project Leader Professor Stephen Kent Microbiology and Immunology
Norovirus replication and innate immunity Project Leader Professor Jason Mackenzie Microbiology and Immunology
Novel Mast Cell-Derived Mediators Project Leader Dr Graham Mackay Pharmacology and Therapeutics
Nutrition: The control of gut hormone release by nutrients Project Supervisor Professor John B Furness Anatomy and Neuroscience
Parker Laboratory: Structural biology and computational drug design Head of Laboratory and Director, Bio21 Institute Professor Michael Parker
Biochemistry and Molecular Biology
Passive antibody immunity for use in combination microbicides Project Leader Professor Damian Purcell Microbiology and Immunology
Pathogenesis of chronic lung disease Head of Laboratory Dr Michelle Hansen
Pharmacology and Therapeutics
Priming of T cell responses to viral infection Project Leader Associate Professor Scott Mueller Microbiology and Immunology
Protein trafficking and cellular architecture Professor Leann Tilley Biochemistry and Molecular Biology
Purcell laboratory: Viral RNA elements, regulation of HIV replication, HIV antibody vaccine Head of Laboratory Professor Damian Purcell
Microbiology and Immunology
Ralph laboratory: Drug targets and gene regulation in Plasmodium falciparum Head of Laboratory Dr Stuart Ralph
Biochemistry and Molecular Biology
Rational Protein Engineering Dr David Ascher Biochemistry and Molecular Biology
Reading laboratory: Innate immune detection and response to respiratory virus infections Head of Laboratory Associate Professor Patrick Reading
Microbiology and Immunology
Regulation of Mast Cell Activation Project Leader Dr Graham Mackay Pharmacology and Therapeutics
Restoring immunocompetency in Chronic Lymphocytic Leukemia Senior Research Officer & Lab Manager Catherine Kennedy, PhD Microbiology and Immunology
RNA mediated control of HIV-1 gene expression Project Leader Professor Damian Purcell Microbiology and Immunology
Robins-Browne laboratory: Medical bacteriology, pathogenesis, bacterial genetics, therapeutics Head of Laboratory Professor Roy Robins-Browne
Microbiology and Immunology
Role of cellular lipids during Flavivirus replication Project Leader Professor Jason Mackenzie Microbiology and Immunology
Role of innate signals in inducing protective T cell immunity Project Leader Associate Professor Sammy Bedoui Microbiology and Immunology
Rouiller laboratory: Understanding how molecular machines function through cryo-electron microscopy Associate Professor Isabelle Rouiller
Biochemistry and Molecular Biology
Salmonella Typhimurium Project Leader Professor Dick Strugnell Microbiology and Immunology
Self-tolerance: Interactions between thymic stroma and dendritic cells Project Leader Professor William (Bill) Heath Microbiology and Immunology
Sex in human malaria parasites Dr Matthew Dixon Biochemistry and Molecular Biology
Skeletal muscle signal transduction related to exercise, metabolic disease and human health Research Project Leader Dr Benjamin Parker
Physiology
Small molecules for BIG targets- Targeting protein-protein interactions with fragments Dr David Ascher Biochemistry and Molecular Biology
Soluble barriers to influenza virus infection Project Leader Associate Professor Patrick Reading Microbiology and Immunology
Solving the native structure of the malaria parasite using cryo-electron microscopy Professor Leann Tilley Biochemistry and Molecular Biology
Staphylococcus aureus & Enterococcus faecium Project Leader Professor Tim Stinear Microbiology and Immunology
Staphylococcus aureus and Staphylococcus epidermidis Project Leader Professor Ben Howden Microbiology and Immunology
Stewart Laboratory: Mechanopharmacology Head of Laboratory Professor Alastair Stewart
Pharmacology and Therapeutics
Stinear laboratory: Bacterial pathogenomics Head of Laboratory Professor Tim Stinear
Microbiology and Immunology
Structural Biology of Infection Professor Michael Parker Biochemistry and Molecular Biology
Strugnell laboratory: Bacterial pathogenesis and host responses Head of Laboratory Professor Dick Strugnell
Microbiology and Immunology
Systems genetics of muscle metabolism Research Project Leader Dr Benjamin Parker
Physiology
T cell responses in the brain during experimental cerebral malaria infection Project Leader Associate Professor Scott Mueller Microbiology and Immunology
T cells in peripheral immunity Project Leader Professor Francis (Frank) Carbone Microbiology and Immunology
Tackling drug resistance Dr David Ascher Biochemistry and Molecular Biology
The Cardiovascular Pharmacology of Snake Venoms From Papua New Guinea and Australia Project Leader Associate Professor Christine Wright Pharmacology and Therapeutics
The innate immune system in the respiratory tract Project Leader Professor David Jackson Microbiology and Immunology
The mechanisms of viral escape in murine and human influenza infection Project Leader Associate Professor Katherine Kedzierska Microbiology and Immunology
The role of CD4+ T cells in viral infections Project Leader Professor Andrew Brooks Microbiology and Immunology
The Role of CXCR7 in Tissue Fibrosis Senior Research Officer & Lab Manager Catherine Kennedy, PhD Microbiology and Immunology
The role of innate immune cells in protection and pathology during influenza virus infection Project Leader Associate Professor Patrick Reading Microbiology and Immunology
The role of protein modifications on muscle development Research Project Leader Dr Benjamin Parker
Physiology
The role of resident memory T cells in barrier immunity and autoimmune disease Project Leader Dr Laura Mackay Microbiology and Immunology
The Treatment of Papuan Taipan Envenoming in Papua New Guinea Project Leader Dr David Williams Pharmacology and Therapeutics
Tilley laboratory: Measuring and modelling malaria parasites to develop new antimalarials Head of Laboratory, ARC Australian Laureate Fellow Professor Leann Tilley
Biochemistry and Molecular Biology
Tissue-resident memory T cells in the skin Project Leader Associate Professor Scott Mueller Microbiology and Immunology
Tracking phenotypically and functionally distinct T cell subsets via T cell repertoire diversity Project Leader Associate Professor Katherine Kedzierska Microbiology and Immunology
Uncovering the interplay between innate immunity and the blood brain barrier in disorders of the CNS Project Leader Professor Christine Wells Anatomy and Neuroscience
Understanding how Anthrax toxins function Associate Professor Isabelle Rouiller Biochemistry and Molecular Biology
Understanding immune dysfunction in acute myeloid leukemia Dr Justine Mintern Biochemistry and Molecular Biology
Understanding the interaction between microbiota and T cell immunity Project Leader Associate Professor Sammy Bedoui Microbiology and Immunology
Understanding the Molecular Consequences of Mutations Dr David Ascher David Ascher Biochemistry and Molecular Biology
Understanding the regulation of tissue-resident memory T cell development Project Leader Dr Laura Mackay Microbiology and Immunology
Understanding the role of glycine in the control of skeletal muscle mass during sepsis Research Project Leader Dr René Koopman
Physiology
Understanding ‘universal’ influenza-specific CD8+ T cell responses Project Leader Associate Professor Katherine Kedzierska Microbiology and Immunology
Using biochemical approaches to investigating the trafficking and mechanism of action of the antiviral molecule, IFITM3 Project Leader Dr Linda Wakim Microbiology and Immunology
Using the immune system to kill tumours Dr Justine Mintern Biochemistry and Molecular Biology
Vaccination against liver-stage Plasmodium for malaria prevention Project Leader Professor William (Bill) Heath Microbiology and Immunology
van Driel laboratory: Immune responses to pathogens Head of Laboratory Professor Ian van Driel
Biochemistry and Molecular Biology
Velkov laboratory: Antiinfective pharmacology Head of Laboratory Associate Professor Tony Velkov
Pharmacology and Therapeutics
Villadangos laboratory: Antigen presenting cells & molecules that initiate T cell immunity against pathogens and cancer Head of Laboratory Professor Jose Villadangos
Microbiology and Immunology
Viral interactions with the innate immune system Project Leader Associate Professor Patrick Reading Microbiology and Immunology
Visualization and formation West Nile Virus replication complexes Project Leader Professor Jason Mackenzie Microbiology and Immunology
Wakim laboratory: Antiviral molecules, mucosal immunology, influenza virus, tissue resident memory T cells Head of Laboratory Dr Linda Wakim
Microbiology and Immunology
Wells laboratory: Stem cell systems Head of Laboratory Professor Christine Wells
Anatomy and Neuroscience
West Nile Virus replication and cellular stress responses Project Leader Professor Jason Mackenzie Microbiology and Immunology
Wilkinson-Berka laboratory: Retinal vascular biology and inflammation Head of Laboratory Professor Jennifer Wilkinson-Berka
Anatomy and Neuroscience Research
“Clock-off time” for inflammation and remodelling in chronic inflammatory diseases: casein kinase inhibitors Professor Alastair Stewart Pharmacology and Therapeutics

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