Precursor exhausted T cells in chronic infection and tumors
Professor Axel Kallies
+61 3 9035 4611
Cytotoxic T cells are essential for tumour control and immunotherapy. However, T cells persistently exposed to antigen during chronic viral infections and in tumours undergo dramatic changes resulting in impaired effector function, a state known as ‘exhaustion’. Recent work by us and others has identified that a subset of these cells (precursor exhausted cells, TPEX) maintain high proliferative potential and respond to checkpoint inhibition. This project examines how TPEX develop and how they can be targeted to advance therapy for chronic infections and cancer.
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