Transcriptional regulation of intestinal organoid differentiation

Project Details

Intestinal organoid cultures recapitulate the stem cell niche in an easily accessible system. Stem cells renew the intestinal epithelium and produce all of the differentiated cells normally found in an in vivo epithelium.

In this project we are using loss of function and overexpression models to examine how EMT transcription factors regulate stem cell behaviour.

Researchers

Franca Casagranda, Research Assistant

Collaborators

Associate Professor Helen Abud, Monash University Biomedicine Discovery Institute

Research Publications

  • Horvay K, Jarde T, Casagranda F, Perreau VM, Haigh K, Nefzger CM, Akhtar R, Gridley T, Berx G, Haigh JJ, Barker N, Polo JM, Hime GR*, Abud HE*.  Snai1 regulates cell lineage allocation and stem cell maintenance in the mouse intestinal epithelium. EMBO Journal 2015; 34(10): 1319-35.
    *joint senior authors,

Research Group

Hime laboratory: Stem cell genetics and Drosophila models of human disease


Faculty Research Themes

Cancer

School Research Themes

Cancer in Biomedicine, Cell Signalling, Stem Cells


Key Contact

For further information about this research, please contact the research group leader.

Department / Centre

Anatomy and Physiology

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