Transcriptional regulation of intestinal organoid differentiation
Professor Gary Hime
+ 61 3 834 45796
Intestinal organoid cultures recapitulate the stem cell niche in an easily accessible system. Stem cells renew the intestinal epithelium and produce all of the differentiated cells normally found in an in vivo epithelium.
In this project we are using loss of function and overexpression models to examine how EMT transcription factors regulate stem cell behaviour.
Franca Casagranda, Research Assistant
Associate Professor Helen Abud, Monash University Biomedicine Discovery Institute
- Horvay K, Jarde T, Casagranda F, Perreau VM, Haigh K, Nefzger CM, Akhtar R, Gridley T, Berx G, Haigh JJ, Barker N, Polo JM, Hime GR*, Abud HE*. Snai1 regulates cell lineage allocation and stem cell maintenance in the mouse intestinal epithelium. EMBO Journal 2015; 34(10): 1319-35.
*joint senior authors,
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