Molecular basis for growth factor surveillance in plasmacytoid dendritic cells

Project Details

Plasmacytoid dendritic cells (pDCs) are rare cells that secrete large quantities of type-I interferon (IFN-I) in response to viral infections. Some viruses encode growth factors (GFs) to induce proliferative lesions that are required for host infectivity. We have found that some GFs can enhance IFN-I production by pDCs. These results suggest that GFs can synergise with Toll-like receptors (TLRs) to enhance IFN-I secretion by pDCs. Alex’s group is interested in identifying how the GF and TLR signaling pathways intersect to enhance IFN-I secretion by pDCs to evoke effective anti-viral immunity.


Dr Patrick Constantinescu, Research Officer

Alexander James Sedgwick, Masters student

Yuhan Sun, Masters student

Research Opportunities

This research project is available to Honours students to join as part of their thesis.
Please contact the Research Group Leader to discuss your options.

Research Group

Barrow laboratory: Tissue immunosurveillance strategies

Faculty Research Themes

Infection and Immunology, Cancer

School Research Themes

Cancer in Biomedicine

Key Contact

For further information about this research, please contact the research group leader.

Department / Centre

Microbiology and Immunology

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