Molecular basis for growth factor surveillance in plasmacytoid dendritic cells
Dr Alexander David Barrow
Plasmacytoid dendritic cells (pDCs) are rare cells that secrete large quantities of type-I interferon (IFN-I) in response to viral infections. Some viruses encode growth factors (GFs) to induce proliferative lesions that are required for host infectivity. We have found that some GFs can enhance IFN-I production by pDCs. These results suggest that GFs can synergise with Toll-like receptors (TLRs) to enhance IFN-I secretion by pDCs. Alex’s group is interested in identifying how the GF and TLR signaling pathways intersect to enhance IFN-I secretion by pDCs to evoke effective anti-viral immunity.
Dr Patrick Constantinescu, Research Officer
Alexander James Sedgwick, Masters student
Yuhan Sun, Masters student
This research project is available to Honours students to join as part of their thesis.
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