Delineating how CD4 T cells ‘help’ establishing effective killer T cell responses

Project Details

Resolution of virus infections relies on the orchestrated activation of dendritic cells (DC), CD4 T cells and killer T cells. We have known for some time that CD4 T cells contribute to killer T cell immunity, but how CD4 T cells, DC and killers interact in vivo is still unclear. Using a model of peripheral virus infection, we found that CD4 T cells contributed to CTL immunity by amplifying the IFN-α/β-induced provision of IL-15 by DC to CTL. Building upon these novel findings, we are currently dissecting the molecular mechanisms.

scheme

Research Group

Bedoui laboratory: Innate and adaptive interactions in immunity to infection



Faculty Research Themes

School Research Themes

Molecular Mechanisms of Disease



Key Contact

For further information about this research, please contact the research group leader.

Department / Centre

Microbiology and Immunology

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