Unravelling the mysteries of E3 ubiquitin ligase in regulating skeletal muscle size and function

Project Details

Regulation of muscle size and function impacts on all aspects of human health and well-being. From performance on the sports-field, to regulation of whole-body metabolism, and independence in aging. A large family of genes known as E3 ubiquitin ligases are paramount in regulation of muscle homeostasis. Changes in the activity of specific members can provoke muscle frailty and wasting, whilst others promote growth and function. Skeletal muscle expresses over 250 E3 ubiquitin ligases, yet only a handful have been characterised.

This research program is investigating which E3 ligases have important functions in muscle health and disease. The projects focus on charting novel E3 ubiquitin ligases, understanding how they regulate muscle size and function, and developing therapeutically relevant methods to control their activity.


A/Prof Paul Gregorevic, Head of Laboratory

Dr Craig Goodman, Senior Research Fellow

Research Opportunities

This research project is available to Honours students to join as part of their thesis.
Please contact the Research Group Leader to discuss your options.

Research Publications

View A/Professor Gregorevic's latest PubMed publications listing here

Research Group

Gregorevic laboratory: Muscle Research and Therapeutics

Faculty Research Themes

Cancer, Neuroscience

School Research Themes

Cancer in Biomedicine, Biomedical Neuroscience, Molecular Mechanisms of Disease, Cell Signalling, Therapeutics & Translation

Key Contact

For further information about this research, please contact the research group leader.

Department / Centre

Anatomy and Physiology

MDHS Research library
Explore by researcher, school, project or topic.