Unravelling the mysteries of E3 ubiquitin ligase in regulating skeletal muscle size and function
Associate Professor Paul Gregorevic
+61 3 9035 7700
Regulation of muscle size and function impacts on all aspects of human health and well-being. From performance on the sports-field, to regulation of whole-body metabolism, and independence in aging. A large family of genes known as E3 ubiquitin ligases are paramount in regulation of muscle homeostasis. Changes in the activity of specific members can provoke muscle frailty and wasting, whilst others promote growth and function. Skeletal muscle expresses over 250 E3 ubiquitin ligases, yet only a handful have been characterised.
This research program is investigating which E3 ligases have important functions in muscle health and disease. The projects focus on charting novel E3 ubiquitin ligases, understanding how they regulate muscle size and function, and developing therapeutically relevant methods to control their activity.
A/Prof Paul Gregorevic, Head of Laboratory
Dr Craig Goodman, Senior Research Fellow
This research project is available to Honours students to join as part of their thesis.
Please contact the Research Group Leader to discuss your options.
View A/Professor Gregorevic's latest PubMed publications listing here
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