Influenza–specific ADCC: Role in a universal flu vaccine?
Professor Stephen Kent
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Influenza mutates regularly to avoid neutralizing antibodies and immune responses that target more conserved areas are needed to combat new flu pandemics. Influenza ADCC has been a neglected area of research in recent decades. We adapted and refined our HIV ADCC assays to study Influenza. We found there is a remarkable degree of cross-reactivity in Influenza ADCC immunity. We found that influenza ADCC can play a role in reducing the severity of the 2009 Swine Flu epidemic in both humans and monkeys. 147,148 * The work opens up a whole new field of Flu immunity. We are now studying how Flu-specific ADCC and antibody-dependent phagocytosis can be induced by vaccination204,240,242 * and lead to protective immunity. Recent work shows ADCC is important in controlling H7N9 avian influenza 234 * and may be important in passive transfer studies258 *.
* superscript number links to a specific publication in the chronological listing on Stephen's blog
Dr Andrew Wheatley, Dr Matt Parsons, Dr Hillary Vanderven with collaborators Pat Reading, Andrew Brooks, and the WHO Flu Centre.
NHMRC project and program grants
Kent laboratory: HIV vaccines; immune responses to HIV-1; immunotherapy
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Molecular Mechanisms of Disease
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