Kristin Brown laboratory

Research Overview

The Brown lab investigates the ways in which aberrant cellular metabolism contributes to malignant transformation, tumour progression and therapy resistance in cancer. This knowledge is applied to the pre-clinical development of novel and more effective interventions for cancer therapy.

Almost a century ago, pioneering studies by Otto Warburg revealed a fundamental difference between the metabolism of normal and cancer cells. However, it is only in the last decade that significant inroads have been made to understanding the critical importance of deregulated cellular metabolism in cancer. Consequently, there is growing interest in developing therapeutic strategies to exploit the metabolic vulnerabilities of cancer cells. We are investigating:

  1. How a variety of cell-intrinsic factors (genetic/epigenetic alterations, tissue of origin, cell of origin) and cell-extrinsic factors (access to nutrients, therapy exposure and microenvironmental interactions) impact the metabolic state of a cancer cell.
  2. How metabolic reprogramming contributes to cell survival, cell proliferation, therapy resistance, metastasis and immune escape.

Staff

Stefan Bjelosevic, Post-doctoral fellow
Rebecca Dawson, Post-doctoral fellow
Sri Vaidyanathan, PhD student
Athena Ong, PhD student
Keziah Ting, PhD student
Olivia Lee, Honours student
Riley Goldsworthy, Honours student
Rasan Sathiqu, Research assistant
Tara Tigani, Research assistant

Research Publications

Click here for a list of Kristin's publications.