Angiotensin and chemoreceptor function
Professor Andrew Allen
+61 3 8344 5838
Whilst there was some information suggesting angiotensin might play a role in autonomic changes produced by hypoxia, a direct effect on the sensory organ, the carotid body, had not been examined. I demonstrated that the carotid body contains a very high density of angiotensin AT1 receptors and that these are localized on the principal chemoreceptor cells. In addition, I demonstrated that, independent of local blood flow changes, angiotensin excites these cells to increase chemoreceptor afferent activity (Allen, A.M: Angiotensin AT 1 receptor-mediated excitation of rat carotid body chemoreceptor afferent activity. J Physiology 1998; 510: 773-782).
Allen laboratory: Central cardiovascular regulation
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Biomedical Neuroscience, Molecular Mechanisms of Disease
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