Tracking phenotypically and functionally distinct T cell subsets via T cell repertoire diversity

Project Details

T cell receptor (TCR) diversity influences both the protective capacity of CD8+ T cells and the subversion of immune control that leads to viral escape. The spectrum of TCR selection and maintenance has implications for improving the functional efficacy of T cell responsiveness and effector function. We are using the cutting edge single-cell PCR technology to understand the factors that determine diversity of T cells responding to a particular antigen. This is critical to our understanding of antiviral immunity. Furthermore, based on the specific TCR signatures of CD8+ T cells at different stages of viral infection, we are able to track distinct subsets of effector and memory CD8+ T cells. Based on the expression of markers such as CD62L, IL-7R, KLRG-1, CD27 and CD43, we aim to understand the fate of particular T cell clones expressing different phenotypic and/or functional characteristics during the immune response. This allows us to make a thorough dissection of antiviral immunity at the clonal level.

Research Group

Kedzierska laboratory: Immunity to pandemic and newly emerged influenza viruses

Faculty Research Themes

Infection and Immunology

School Research Themes

Molecular Mechanisms of Disease

Key Contact

For further information about this research, please contact the research group leader.

Department / Centre

Microbiology and Immunology

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