Understanding the plasticity of skeletal muscle in health and disease

Project Details

Skeletal muscle is comprised of diverse fibre types that differ in size, metabolic and contractile properties; classically referred to as either 'slow, oxidative' or 'fast, glycolytic'. These properties are not fixed but can change in response to imposed demands, a process known as 'plasticity'. Understanding the biological mechanisms regulating fibre phenotype and the adaptive response across muscles of varying phenotypes has not been fully resolved. Addressing these research gaps may also identify potential therapeutic targets to improve quantity and quality of life across many disease conditions. The objectives of this project are to: 1) understand the biological mechanisms regulating fibre size, phenotype and plasticity; and 2) whether modifying skeletal muscle attributes can protect against injury and disease. This project will utilise genetic, pharmacological and lifestyle approaches to interrogate the molecular, metabolic and contractile properties of fast and slow muscles in a variety of healthy and pathological states; including but not limited to muscular dystrophies, cancer cachexia, muscle injury and repair, and ageing.


Dr Justin Hardee, Research Fellow

Professor Gordon Lynch, Head of Laboratory


Research Opportunities

This research project is available to Honours students to join as part of their thesis.
Please contact the Research Group Leader to discuss your options.

Research Group

Lynch laboratory: Basic and clinical myology

Faculty Research Themes


School Research Themes

Biomedical Neuroscience, Molecular Mechanisms of Disease

Key Contact

For further information about this research, please contact the research group leader.

Department / Centre

Anatomy and Physiology

MDHS Research library
Explore by researcher, school, project or topic.