Deciphering the relative contributions of different dendritic cells to killer T cell responses

Project Details

Continuing our endeavor to resolve the role of dendritic cells (DC) in virus infections, this project investigates the relative contributions of different DC subtypes to killer T cell priming and examines the molecular pathways involved (direct vs. cross-presentation). Utilizing in vivo models that remove the capacity of cells to directly present viral antigen, we found that robust virus-specific killer T cell responses depend on cross-presentation. We are currently delineating the underlying mechanisms.

scheme

Research Group

Bedoui laboratory: Innate and adaptive interactions in immunity to infection


Faculty Research Themes

Infection and Immunology

School Research Themes

Molecular Mechanisms of Disease


Key Contact

For further information about this research, please contact the research group leader.

Department / Centre

Microbiology and Immunology

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