Deciphering the relative contributions of different dendritic cells to killer T cell responses
-
Professor Sammy Bedoui+61 3 8344 9911
Project Details
Continuing our endeavor to resolve the role of dendritic cells (DC) in virus infections, this project investigates the relative contributions of different DC subtypes to killer T cell priming and examines the molecular pathways involved (direct vs. cross-presentation). Utilizing in vivo models that remove the capacity of cells to directly present viral antigen, we found that robust virus-specific killer T cell responses depend on cross-presentation. We are currently delineating the underlying mechanisms.
Research Group
Bedoui laboratory: Innate and adaptive interactions in immunity to infection
Faculty Research Themes
School Research Themes
Infection & Immunity, Molecular Mechanisms of Disease
Key Contact
For further information about this research, please contact the research group leader.
Department / Centre
MDHS Research library
Explore by researcher, school, project or topic.