Mackenzie laboratory: Intracellular virus replication and innate immunity
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Head of Laboratory
Professor Jason Mackenziejason.mackenzie@unimelb.edu.au
+61 3 9035 8376
Research Overview
Our overall objectives are to investigate and unravel the replication mechanism of two positive-stranded RNA viruses (West Nile virus [a flavivirus] and Mouse Norovirus [a Norovirus]) that are highly pathogenic to humans and cause outbreaks of encephalitis and gastroenteritis. Our aims are to determine how and where these viruses replicate within infected cells and what host components/organelles are "used and abused" by the virus. We aim to correlate this abuse of host with the pathogenic outcomes associated with viral infection. In conjunction with these studies we are investigating how viruses can evade our immune system and in particular how viruses can bypass the antiviral activities of our first line of defence; the innate immune system.
Staff
- Dr Turgut Aktepe, Research Officer
- Dr Susann Liebscher, Research Officer
- Dr Soroush Sarvestani, Research Officer
- Mr Adam Lopez-Denman, PhD Student
- Miss Svenja Fritzlar, PhD Student
- Mr Joshua Deerain, PhD Student