Mackenzie laboratory: Intracellular virus replication and innate immunity
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Professor Jason Mackenziejason.mackenzie@unimelb.edu.au
+61 3 9035 8376
Research Overview
Our overall objectives are to investigate and unravel the replication mechanism of two positive-stranded RNA viruses (West Nile virus [a flavivirus] and Mouse Norovirus [a Norovirus]) that are highly pathogenic to humans and cause outbreaks of encephalitis and gastroenteritis. Our aims are to determine how and where these viruses replicate within infected cells and what host components/organelles are "used and abused" by the virus. We aim to correlate this abuse of host with the pathogenic outcomes associated with viral infection. In conjunction with these studies we are investigating how viruses can evade our immune system and in particular how viruses can bypass the antiviral activities of our first line of defence; the innate immune system.
Staff
- Dr Turgut Aktepe, Research Officer
- Dr Susann Liebscher, Research Officer
- Dr Soroush Sarvestani, Research Officer
- Mr Adam Lopez-Denman, PhD Student
- Miss Svenja Fritzlar, PhD Student
- Mr Joshua Deerain, PhD Student
Research Projects
- Student projects
- Autophagy and Norovirus replication
- Norovirus replication and innate immunity
- Visualization and formation West Nile Virus replication complexes
- West Nile Virus replication and cellular stress responses
- Role of cellular lipids during Flavivirus replication
Faculty Research Themes
School Research Themes
Infection & Immunity, Molecular Mechanisms of Disease
Key Contact
For further information about this research, please contact Head of Laboratory Professor Jason Mackenzie
Department / Centre
Unit / Centre
Mackenzie laboratory: Intracellular virus replication and innate immunity
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