Cancer in Biomedicine

Cancer research programs within the School focus on characterising the molecular mechanisms responsible for cancer progression, predisposition and resistance to treatment

Groups / Projects Research Lead Dept / Centre
A novel link between metabolism and host defence: O-GlcNAc glycosylation Professor Jose Villadangos Biochemistry and Molecular Biology
Analysing genetic roles of RNA-binding proteins and alternative splicing in Drosophila stem cells Project Leader Professor Gary Hime Anatomy and Neuroscience
Analysing protein structures Dr David Ascher Biochemistry and Molecular Biology
Applications of Nanopore sequencing Project Leader Dr Mike Clark Anatomy and Neuroscience
Ascher laboratory: Structural biology and bioinformatics Head of Laboratory Dr David Ascher
Biochemistry and Molecular Biology
Bo&MeRanG Research Projects Melbourne Coordinator Dr Marie Greyer
Bogoyevitch laboratory: Regulatory biology Head of Laboratory Associate Professor Marie Bogoyevitch
Biochemistry and Molecular Biology
Characterising the pathways responsible for ICU-acquired weakness Research Project Leader Dr René Koopman
Physiology
Cheng laboratory: Molecular enzymology of protein kinases and phosphatases involved in human diseases Head of Laboratory Associate Professor Heung-Chin Cheng
Biochemistry and Molecular Biology
Cheng laboratory: Stem cell and organ size control regulation Head of Laboratory Dr Louise Cheng
Anatomy and Neuroscience
Clinical Proteomics Project Leader Dr Jonathon Mangum Pharmacology and Therapeutics
Decoding the trafficking of immune receptors Dr Justine Mintern Biochemistry and Molecular Biology
Defining new roles for the Hippo signalling pathway in skeletal muscle Research Project Leader Associate Professor Paul Gregorevic
Physiology
Designing better drugs Dr David Ascher Biochemistry and Molecular Biology
Designing new optogenetic tools for biomedical research A/Prof Danny Hatters Biochemistry and Molecular Biology
Developing innovative animal and cell culture models to study and treat muscular dystrophies Research Project Leader Associate Professor Paul Gregorevic
Physiology
Towards understanding new therapies for obesity and diabetes: discovering new regulators of lipid metabolism Research Project Leader Professor Matthew Watt
Physiology
EMT regulators in intestinal and germline stem cells Project Leader Professor Gary Hime Anatomy and Neuroscience
Establishing the effect of glycine/serine metabolism on skeletal muscle cell growth Research Project Leader Dr René Koopman
Physiology
Exploiting nanoparticles as vaccines Dr Justine Mintern Biochemistry and Molecular Biology
Exploring new roles for the TGFβ signalling network as a key regulator of skeletal muscle in health and disease Research Project Leader Associate Professor Paul Gregorevic
Physiology
Finding clarity within a blizzard- guiding the solution of cryo-EM structures Dr David Ascher Biochemistry and Molecular Biology
Gregorevic laboratory: Muscle Research and Therapeutics Head of Laboratory Associate Professor Paul Gregorevic
Physiology
Hime laboratory: Stem cell genetics and Drosophila models of human disease Head of Laboratory Professor Gary Hime
Anatomy and Neuroscience
Hinde laboratory: Biophysics of Nuclear Organisation Head of Research Group Dr Elizabeth Hinde
Biochemistry and Molecular Biology
How do dietary nutrients affect the ability of stem cells and stem cell-derived tumours to grow and divide? Dr Louise Cheng Anatomy and Neuroscience
How do neurons maintain their specialised status? Dr Louise Cheng Anatomy and Neuroscience
How do tumours compete with other tissues for resources? Dr Louise Cheng Anatomy and Neuroscience
How infection and trauma cause dendritic cell paralysis and lethal immunosuppression Professor Jose Villadangos Microbiology and Immunology
How to harness the immune system to cure cancer: adoptive cell immunotherapy Professor Jose Villadangos Microbiology and Immunology
Immunoregulatory functions of the MARCH family of ubiquitin ligases Professor Jose Villadangos Biochemistry and Molecular Biology
Investigating the Dystrophin-Glycoprotein Complex to Protect Muscles from Wasting Conditions Research Project Leader Professor Gordon Lynch
Physiology
Investigating the role of cachexia in the response to surgical tumour resection in mice Research Project Leader Professor Gordon Lynch
Physiology
Koopman laboratory: Clinical nutrition and muscle metabolism Head of Laboratory Dr René Koopman
Physiology
Learning from skeletal muscles to develop new treatments for cancer Research Project Leader Associate Professor Paul Gregorevic
Physiology
Lynch laboratory: Basic and clinical myology Head of Laboratory Professor Gordon Lynch
Physiology
Mangum Lab: Translational Proteomics Head of Laboratory Dr Jonathan Mangum
Pharmacology and Therapeutics
Manipulating immunity to fight infection and tumours Dr Justine Mintern Biochemistry and Molecular Biology
Mantamadiotis laboratory: Brain Cancer Molecular Biology Dr Theo Mantamadiotis
Microbiology and Immunology
Metabolic reprogramming of skeletal muscle stem cells Research Project Leader Professor Gordon Lynch Physiology
Molecular basis for growth factor surveillance in natural killer cells Dr Alexander David Barrow Microbiology and Immunology
Molecular basis for growth factor surveillance in plasmacytoid dendritic cells Dr Alexander David Barrow Microbiology and Immunology
Molecular mechanisms of drug resistance in cancer Project Leader Dr Jonathon Mangum Pharmacology and Therapeutics
MR1 – a molecular alarm system that detects pathogen metabolites Professor Jose Villadangos Microbiology and Immunology
Mueller laboratory: Visualising the immune system in action Head of Laboratory Associate Professor Scott Mueller
Microbiology and Immunology
Novel regulators of germline stem cells Project Leader Professor Gary HIme Anatomy and Neuroscience
Parker Laboratory: Structural biology and computational drug design Head of Laboratory and Director, Bio21 Institute Professor Michael Parker
Biochemistry and Molecular Biology
Personalising treatments for genetic diseases Dr David Ascher Biochemistry and Molecular Biology
Pébay laboratory: Stem Cell Disease Modelling Head of Laboratory Professor Alice Pebay
Anatomy and Neuroscience
Rational Protein Engineering Dr David Ascher Biochemistry and Molecular Biology
Reid laboratory: Proteomics and lipidomics in health and disease Head of Laboratory Professor Gavin E. Reid
Biochemistry and Molecular Biology
Restoring immunocompetency in Chronic Lymphocytic Leukemia Senior Research Officer & Lab Manager Catherine Kennedy, PhD Microbiology and Immunology
Rouiller laboratory: Understanding how molecular machines function through cryo-electron microscopy Associate Professor Isabelle Rouiller
Biochemistry and Molecular Biology
Small molecules for BIG targets- Targeting protein-protein interactions with fragments Dr David Ascher Biochemistry and Molecular Biology
Structural Biology of Cancer Professor Michael Parker Biochemistry and Molecular Biology
Tackling drug resistance Dr David Ascher Biochemistry and Molecular Biology
Taylor: Jack Brockhoff Reconstructive Plastic Surgery Research Unit Head of Research Unit Professor Ian Taylor
Anatomy and Neuroscience
Therapeutic potential of skeletal muscle plasticity and slow muscle programming for muscular dystrophy Research Project Leader Professor Gordon Lynch
Physiology
Transcriptional regulation of intestinal organoid differentiation Project Leader Professor Gary Hime Anatomy and Neuroscience
Understanding how the ATPase p97 functions at molecular level Associate Professor Isabelle Rouiller Biochemistry and Molecular Biology
Understanding immune dysfunction in acute myeloid leukemia Dr Justine Mintern Biochemistry and Molecular Biology
Understanding the immune microenvironment in brain tumours Dr Theo Mantamadiotis Microbiology and Immunology
Understanding the Molecular Consequences of Mutations Dr David Ascher David Ascher Biochemistry and Molecular Biology
Unravelling the mysteries of E3 ubiquitin ligase in regulating skeletal muscle size and function Research Project Leader Associate Professor Paul Gregorevic
Physiology
Using the immune system to kill tumours Dr Justine Mintern Biochemistry and Molecular Biology
Using transcriptional analyses to understand recognition of tumours by natural killer cells Professor Andrew Brooks Microbiology and Immunology
Watt laboratory: Metabolism and Diabetes Head of Laboratory Professor Matthew Watt
Physiology

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