Whole body analysis of human T cell development and function

Project Details

The majority of T cell responses occur in tissues; however, current knowledge of human T cells is largely derived from blood. In collaboration with the Australian Donation and Transplantation BioBank (ADTB), our group studies the T cell landscape in multiple lymphoid, visceral and barrier sites from research-consented organ donors. We seek to investigate immune cell distribution across the body and understand the pathways that guide T cell differentiation and maintenance in diverse tissue sites. Our work aims to better-inform the development of immunotherapies that modulate tissue-based cellular responses.

Research Group

Mackay laboratory: Tissue-resident memory T cells; lymphocyte differentiation; peripheral immunity

Faculty Research Themes

Infection and Immunology

School Research Themes

Molecular Mechanisms of Disease

Key Contact

For further information about this research, please contact the research group leader.

Department / Centre

Microbiology and Immunology

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