Project 2. CD4+ T cells in acute Graft-versus-Host Disease
Associate Professor Ashraful Haque
The Haque group are examining how donor-derived CD4+ T cells after allogeneic hematopoietic stem cell transplantation, differentiate into pro-inflammatory, regulatory and quiescent cell states in the gastro-intestinal tract, thus controlling the severity of Graft-versus-Host Disease. In experimental in vivo models, we find rapid emergence of TCF1hi quiescent T cells that migrate to the gut, and retain a capacity to mount secondary effector responses therein. To translate these findings into humans, we are applying scRNA-seq to examine peripheral blood immune responses in Phase III clinical trials for prevention of acute GVHD.
This research project is available to Honours students to join as part of their thesis.
Please contact the Research Group Leader to discuss your options.
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