Understanding the interaction between microbiota and T cell immunity

• 
  Project Leader
  Professor Sammy Bedoui

  sbedoui@unimelb.edu.au

  View researcher's webpage

  +61 3 8344 9911

Project Details

Development of autoimmune diseases has been linked to disturbances in the microbiota that normally colonises our body surfaces. However, precisely how these microorganisms and the resulting stimulation of the immune system impact on different T cell subsets is less well understood. Building on extensive preliminary data available in the lab, this project investigates how microbiota influences T cell-mediated responses, especially in regards to their metabolism, and its influence on autoimmune disease, such as type I diabetes.

Researchers

Dr Annabell Bachem, RO

Collaborators

Professor Thomas Gebhardt, Department of Microbiology and Immunology, UoM
Professor Stephen Turner, DMI
Professor Dick Strugnell, DMI
Professor Tim Stinear, DMI
Professor Elizabeth Hartland, Department of Microbiology and Immunology, UoM
Professor Malcolm McConville, Metabolomics Australia / Bio21, UoM

Funding

NHMRC, German Research Council, University of Melbourne

Research Publications

• Baker PJ, De Nardo D, Moghaddas F, Tran LS, Bachem A, Nguyen T, Hayman T, Tye H, Vince JE, Bedoui S, Ferrero RL, Masters SL. Posttranslational Modification as a Critical Determinant of Cytoplasmic Innate Immune Recognition. Physiol Rev 2017 Jul 1; 97(3): 1165-1209. doi: 10.1152/physrev.00026.2016. Review.
• Brown AS, Yang C, Fung KY, Bachem A, Bourges D, Bedoui S, Hartland EL, van Driel IR. Cooperation between Monocyte-Derived Cells and Lymphoid Cells in the Acute Response to a Bacterial Lung Pathogen. PLoS Pathog 2016 Jun 14; 12(6): e1005691. doi: 10.1371/journal.ppat.1005691. eCollection 2016 Jun.
• Greyer M, Whitney PG, Stock AT, Davey GM, Tebartz C, Bachem A, Mintern JD, Strugnell RA, Turner SJ, Gebhardt T, O'Keeffe M, Heath WR, Bedoui S. T Cell Help Amplifies Innate Signals in CD8(+) DCs for Optimal CD8(+) T Cell Priming. Cell Rep 2016 Jan 26; 14(3):586-97. doi: 10.1016/j.celrep.2015.12.058. Epub 2016 Jan 7.
• Hartung E, Becker M, Bachem A, Reeg N, Jäkel A, Hutloff A, Weber H, Weise C, Giesecke C, Henn V, Gurka S, Anastassiadis K, Mages HW, Kroczek RA. Induction of potent CD8 T cell cytotoxicity by specific targeting of antigen to cross-presenting dendritic cells in vivo via murine or human XCR1. J Immunol 2015 Feb 1; 194(3):1069-79. doi: 10.4049/jimmunol.1401903. Epub 2014 Dec 17.
• Becker M, Güttler S, Bachem A, Hartung E, Mora A, Jäkel A, Hutloff A, Henn V, Mages HW, Gurka S, Kroczek RA. Ontogenic, Phenotypic, and Functional Characterization of XCR1(+) Dendritic Cells Leads to a Consistent Classification of Intestinal Dendritic Cells Based on the Expression of XCR1 and SIRPα. Front Immunol 2014 Jul 28; 5:326. doi: 10.3389/fimmu.2014.00326. eCollection 2014.
• Bachem A, Hartung E, Güttler S, Mora A, Zhou X, Hegemann A, Plantinga M, Mazzini E, Stoitzner P, Gurka S, Henn V, Mages HW, Kroczek RA. Expression of XCR1 Characterizes the Batf3-Dependent Lineage of Dendritic Cells Capable of Antigen Cross-Presentation. Front Immunol 2012 Jul 18; 3:214. doi: 10.3389/fimmu.2012.00214. eCollection 2012.