Molecular basis for growth factor surveillance in natural killer cells
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Dr Alexander David Barrow+61390356297
Project Details
Many tumours secrete Platelet-derived growth factor (PDGF)-D to promote tumour growth. NK cells have evolved the activating ITAM receptor NKp44 to sense the expression of PDGF-D and trigger the secretion of cytokines that halt tumour growth. An alternatively spliced NKp44 isoform encodes an ‘ITIM’ that is predicted to be inhibitory and is associated with poor survival in cancer. Tumours may induce this inhibitory NKp44 form to dampen NK cell function as a form of immune evasion. Alex’s group is determining the functions of the different NKp44 isoforms and how they impact NK cell surveillance of cancers expressing PDGF-D.
Researchers
Dr Patrick Constantinescu, Research Officer
Alexander James Sedgwick, Masters student
Yuhan Sun, Masters student
Research Opportunities
This research project is available to Honours students to join as part of their thesis.
Please contact the Research Group Leader to discuss your options.
Research Group
Barrow laboratory: Tissue immunosurveillance strategies
Faculty Research Themes
Infection and Immunology, Cancer
School Research Themes
Key Contact
For further information about this research, please contact the research group leader.
Department / Centre
MDHS Research library
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