Investigating the Dystrophin-Glycoprotein Complex to Protect Muscles from Wasting Conditions
Professor Gordon Lynch
+61 3 8344 0065
The dystrophin-glycoprotein complex (DGC) is a multi-protein structure required to maintain integrity of the muscle fibre membrane and to transmit force, by linking the actin cytoskeleton with the extracellular matrix. Importantly, we and others have shown the DGC also plays a critical role in the signalling mechanisms that maintain muscle homeostasis and membrane localisation of dystrophin is perturbed in muscles wasting because of cancer cachexia, sepsis, unloading, denervation and advanced ageing, which are all associated with low level, chronic inflammation.
Identifying therapeutic approaches to restore the DGC at the muscle fibre membrane is essential for improving clinical outcomes for patients whose muscles are wasting and seemingly unresponsive to other treatments.
This project will test the hypothesis that loss of DGC integrity at the fibre membrane is implicated in multiple wasting conditions and that post-translational modification modulates these DGC interactions to preserve and protect muscles in different muscle wasting states.
Dr Kristy Swiderski, Senior Research Fellow
Professor Gordon Lynch, Head of Laboratory
2018-2021 NHMRC Project Grant. Rescuing the Dystrophin-Glycoprotein Complex to protect muscles from wasting conditions
This research project is available to PhD students, Masters by Research, Honours students, Master of Biomedical Science, Post Doctor Researchers to join as part of their thesis.
Please contact the Research Group Leader to discuss your options.
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