How do neural stem cells maintain quiescence?
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A/Professor Louise Cheng
Project Details
Lipid droplet (red) and Hh (blue) in the glial niche co-operate to non-autonomously regulate NSC proliferation
The brain is the cognitive control centre of the body consisting of neurons and glia made by multipotent progenitor cells called Neural Stem Cells (NSCs). In the adult mammalian brain, NSCs exists in a mitotically inactive (quiescent G0) state but can proliferate in response to environmental inputs such as feeding or exercise, which provide a regenerative reserve for tissue repair and age-related cell loss. We are interested in identifying non-cell autonomous signals from the stem cell niche and the adipose tissue that can influence whether stem cells proliferate or stay quiescent.
Researchers
Qian Dong
Collaborators
Peter MacCallum Cancer Institute
Research Publications
Froldi, F., et al. (2020). Glial Hedgehog and lipid metabolism regulate neural stem cell proliferation in Drosophila. EMBO. https://doi.org/10.1101/2020.05.18.100990
Research Group
Cheng laboratory: Stem cell and organ size control regulation
Faculty Research Themes
School Research Themes
Biomedical Neuroscience, Cancer in Biomedicine, Systems Biology, Molecular Mechanisms of Disease
Key Contact
For further information about this research, please contact the research group leader.
Department / Centre
MDHS Research library
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