How do dietary nutrients affect the ability of stem cells and stem cell-derived tumours to grow and divide?

Project Details

Leucine but not Histidine drop out significantly affects the development of ovaries compared to animals fed a control (CDD) diet

The effect of diet on stem cell proliferation and tumour growth is poorly characterised. Using a chemically defined diet together with metabolomic approaches, we are interested in identifying metabolic alterations associated with dedifferentiation, stem cell reactivation and cancer.

Researchers

Dr Francesca Froldi, Post Doctoral Researcher

Edel Alvarez

Qian Dong

Collaborators

Peter MacCallum Cancer Institute

Research Publications

Froldi, F., et al. (2019). Histidine is selectively required for the growth of Myc‚Äźdependent dedifferentiation tumours in the Drosophila CNS. EMBO J. 38:e99895.  https://doi.org/10.15252/embj.201899895

Froldi, F., Szuperak, M., et al. (2015). The transcription factor Nerfin-1 prevents reversion of neurons into neural stem cells. Genes & Dev. 29: 129-143. doi: 10.1101/gad.250282.114

Research Group

Cheng laboratory: Stem cell and organ size control regulation



Faculty Research Themes

School Research Themes

Biomedical Neuroscience, Cancer in Biomedicine, Systems Biology, Molecular Mechanisms of Disease



Key Contact

For further information about this research, please contact the research group leader.

Department / Centre

Anatomy and Physiology

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