How do dietary nutrients affect the ability of stem cells and stem cell-derived tumours to grow and divide?

• 
  Project Leader
  A/Professor Louise Cheng

  lcheng1@unimelb.edu.au

  View researcher's webpage

Project Details

^{Leucine but not Histidine drop out significantly affects the development of ovaries compared to animals fed a control (CDD) diet}

The effect of diet on stem cell proliferation and tumour growth is poorly characterised. Using a chemically defined diet together with metabolomic approaches, we are interested in identifying metabolic alterations associated with dedifferentiation, stem cell reactivation and cancer.

Researchers

Dr Francesca Froldi, Post Doctoral Researcher

Edel Alvarez

Qian Dong

Collaborators

Peter MacCallum Cancer Institute

Research Publications

Froldi, F., et al. (2019). Histidine is selectively required for the growth of Myc‐dependent dedifferentiation tumours in the Drosophila CNS. EMBO J. 38:e99895.  https://doi.org/10.15252/embj.201899895

Froldi, F., Szuperak, M., et al. (2015). The transcription factor Nerfin-1 prevents reversion of neurons into neural stem cells. Genes & Dev. 29: 129-143. doi: 10.1101/gad.250282.114