How do dietary nutrients affect the ability of stem cells and stem cell-derived tumours to grow and divide?
Leucine but not Histidine drop out significantly affects the development of ovaries compared to animals fed a control (CDD) diet
The effect of diet on stem cell proliferation and tumour growth is poorly characterised. Using a chemically defined diet together with metabolomic approaches, we are interested in identifying metabolic alterations associated with dedifferentiation, stem cell reactivation and cancer.
Dr Francesca Froldi, Post Doctoral Researcher
Peter MacCallum Cancer Institute
Froldi, F., et al. (2019). Histidine is selectively required for the growth of Myc‐dependent dedifferentiation tumours in the Drosophila CNS. EMBO J. 38:e99895. https://doi.org/10.15252/embj.201899895
Froldi, F., Szuperak, M., et al. (2015). The transcription factor Nerfin-1 prevents reversion of neurons into neural stem cells. Genes & Dev. 29: 129-143. doi: 10.1101/gad.250282.114
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