Developing a novel class of therapeutics for muscle wasting and frailty

Project Details

This project is investigating the role of ubiquitin-signalling and characterising a series of new drugs to combat against muscle wasting and enhance rehabilitation prospects.


A/Prof Paul Gregorevic, University of Melbourne

Prof Stephen Wilton

Research Opportunities

This research project is available to Honours students to join as part of their thesis.
Please contact the Research Group Leader to discuss your options.

Research Publications

Davey, J.R., Watt, K.I., Parker, B.L., Chaudhuri, R., Ryall, J.G., Cunningham, L., Qian, H., Sartorelli, V., Sandri, M., Chamberlain, J., James, D.E., Gregorevic, P. Integrated expression analysis of muscle hypertrophy identifies Asb2 as a negative regulator of muscle mass JCI Insight (2016) 1(5): pii: e85477. PMID: 27182554

Mills, R.J., Parker, B.L., Monnot, P., Needham, E.J., Vivien, C.J., Ferguson, C., Parton, R.G., James, D.E., Porrello, E.R., Hudson, J.E. Development of a human skeletal micro muscle platform with pacing capabilities. Biomaterials (2019) 198:217-227. PMID: 30527761

Mills, R.J., Titmarsh, D.M., Koenig, X., Parker, B.L., Ryall, J.G., Quaife-Ryan, G.A., Voges, H.K., Hodson, M.P., Ferguson, C., Drowley, L., Plowright, A.T., Needham, E.J., Wang, Q.D., Gregorevic, P., Xin, M., Thomas, W.G., Parton, R.G., Nielsen, L.K, Launikonis, B.S., James, D.E., Elliott, D.A., Porrello, E.R., Hudson, J.E. Functional screening in human cardiac organoids reveals a metabolic mechanism for cardiomyocyte cell cycle arrest. PNAS (2017) 114(40):E8372-E8381. PMID: 28916735

Research Group

Parker laboratory: Metabolic Proteomics & Signal Transduction

Faculty Research Themes

Infection and Immunology

School Research Themes

Molecular Mechanisms of Disease, Cell Signalling, Systems Biology

Key Contact

For further information about this research, please contact the research group leader.

Department / Centre

Anatomy and Physiology

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