Skeletal muscle signal transduction related to exercise, metabolic disease and human health

Project Details

This project uses functional screening and proteomics to understand how signal transduction regulates metabolism. It aims to identify new therapeutic targets to treat diabetes and metabolic disease.

Research Opportunities

This research project is available to Honours students to join as part of their thesis.
Please contact the Research Group Leader to discuss your options.

Research Publications

*Hoffman, N.J., *Parker, B.L., Chaudhuri, R., Fisher-Wellman, K.H., Kleinert, M., Humphrey, S.J., Yang, P., Holliday, M., Trefely, S., Fazakerley, D.J., Stöckli, J., Burchfield, J.G., Jensen, T.E., Jothi, R., Kiens, B., Wojtaszewski, J.F., Richter, E.A., James, D.E. Global Phosphoproteomic Analysis of Human Skeletal Muscle Reveals a Network of Exercise-Regulated Kinases and AMPK Substrates. Cell Metab (2015) 22(5): 922 – 935. PMID: 26437602

Hingst, J.R., Bruhn, L., Hansen, M.B., Rosschou, M.F., Birk, J.B., Fentz, J., Foretz, M., Viollet, B., Sakamoto, K., Færgeman, N.J., Havelund, J.F., Parker, B.L., James, D.E., Kiens, B., Richter, E.A., Jensen, J., Wojtaszewski, J.F.P. Exercise-induced molecular mechanisms promoting glycogen supercompensation in human skeletal muscle. Mol Metab (2018) 16:24-34. PMID: 30093357

Kleinert, M., Parker, B.L., Jensen, T.E., Raun, S.H., Pham, P., Han, X., James, D.E., Richter, E.A., Sylow, L. Quantitative proteomic characterization of cellular pathways associated with altered insulin sensitivity in skeletal muscle following high-fat diet feeding and exercise training. Sci Rep. (2018) 8(1): 10723. PMID: 30013070

Whitham, M., Parker, B.L., Friedrichsen, M., Hingst, J.R., Hjorth, M., Hughes, W.E., Egan, C.L., Cron, L.N.N., Watt, K.I., Kuchel, R.P., Jayasooriah, N., Estevez, E., Petzold, T., Suter, C.M., Gregorevic, P., Kiens, B., Richter, E.A., James, D.E., Wojtaszewski, J.F.P., Febbraio, M.A., Quantitative proteomic analysis of the human extracellular vesicle proteome reveals a novel mechanism for tissue cross-talk during exercise. Cell Metabolism (2017) 27(1):237-251

Parker, B.L., Burchfield, J.G., Clayton, D., Geddes, T.A., Payne, R.J., Kiens, B., Wojtaszewski, J., Richter, E.A., James, D.E. Multiplexed temporal quantification of the exercise-regulated plasma peptidome. Mol Cell Proteomics (2017) 16(12):2055-2068. PMID: 28982716

Kleinert, M., Parker, B.L., Fritzen, A.M., Knudsen, J.R., Jensen, T.E., Kjøbsted, R., Sylow, L., Ruegg, M., James, D.E., Richter, E.A. Mammalian target of rapamycin complex 2 regulates muscle glucose uptake during exercise in mice. J Physiol (2017) 51(13): 7502-7510. PMID: 28464351

Needham, E.J., Parker, B.L., Burykin, T., James, D.E., Humphrey, S.J. Illuminating the dark phosphoproteome. Science Signaling (2019) 12(565). PMID: 30670635

Research Group

Parker laboratory: Metabolic Proteomics & Signal Transduction

Faculty Research Themes

Infection and Immunology

School Research Themes

Molecular Mechanisms of Disease, Cell Signalling, Systems Biology

Key Contact

For further information about this research, please contact the research group leader.

Department / Centre

Anatomy and Physiology

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