Infection & Immunity

Research in the School is focussed on mechanisms of infection and immunity and the development of new ways to control and treat infectious diseases. Current research programs include the molecular analysis of bacterial and viral infections as well as understanding the development and function of the immune system.

Groups / Projects Research Lead Dept / Centre
A mass spectrometry assay for quantitative analysis of P. falciparum Histidine Rich Protein 2 Professor Gavin E. Reid Biochemistry and Molecular Biology
A new function of the cytokine BAFF in dendritic cell maturation: Implications for immunity and cancers Professor Fabienne Mackay | Dr Beatriz Garcillan Microbiology and Immunology
A universal vaccine against influenza A Professor David Jackson Microbiology and Immunology
Alternative splicing in human parasites Dr Stuart Ralph Biochemistry and Molecular Biology
Aminoacyl-tRNA synthetases enzymes as drug targets Dr Stuart Ralph Biochemistry and Molecular Biology
Analysing and Interpreting protein structures Dr David Ascher Biochemistry and Molecular Biology
Antibody dependent cellular cytotoxicity - a neglected anti-HIV iImmune response! Professor Stephen Kent Microbiology and Immunology
Antimicrobial resistant bacterial pathogens Professor Ben Howden Microbiology and Immunology
Application of genomics to public health and clinical microbiology Professor Ben Howden Microbiology and Immunology
Ascher laboratory: Structural biology and bioinformatics Dr David Ascher
Biochemistry and Molecular Biology
Australian bite and sting trends: Australian Venomous Injury Project (AVIP) Dr Ronelle Welton Pharmacology and Therapeutics
Australian Venom Research Unit Dr David Williams
Pharmacology and Therapeutics
Autophagy and Norovirus replication Associate Professor Jason Mackenzie Microbiology and Immunology
Autophagy: a Novel Pathway of Antigen Presentation in Dendritic Cells Professor Jose Villadangos Microbiology and Immunology
Bedoui laboratory: Innate and adaptive interactions in immunity to infection Associate Professor Sammy Bedoui
Microbiology and Immunology
Biolpolymer-based vaccine delivery systems Professor David Jackson Microbiology and Immunology
Bogoyevitch laboratory: Regulatory biology Associate Professor Marie Bogoyevitch
Biochemistry and Molecular Biology
Brooks laboratory: Innate immunity; anti-viral immunity Professor Andrew Brooks
Microbiology and Immunology
Brown laboratory: Immunology; virology; vaccinology Professor Lorena (Lori) Brown
Microbiology and Immunology
Carbone laboratory: Immune response to herpes simplex virus Professor Francis (Frank) Carbone
Microbiology and Immunology
Cell biology of membrane receptors regulating the serum half-life of therapeutic proteins Professor Paul Gleeson Biochemistry and Molecular Biology
Cell surface receptors for attachment and entry of influenza virus into cells of the innate immune system Associate Professor Patrick Reading Microbiology and Immunology
Checkmating HIV - trapping immune escape HIV strains Professor Stephen Kent Microbiology and Immunology
Chronic immune activation during treated HIV disease Professor Damian Purcell Microbiology and Immunology
Combined influenza-AIDS vaccines Professor Stephen Kent Microbiology and Immunology
Correlates of severe and fatal influenza disease in high-risk groups Associate Professor Katherine Kedzierska Microbiology and Immunology
Coulson laboratory: Rotavirus pathogenesis and immunity Associate Professor Barbara Coulson
Microbiology and Immunology
DC targetting vaccines Professor Stephen Kent Microbiology and Immunology
Deciphering the relative contributions of different dendritic cells to killer T cell responses Associate Professor Sammy Bedoui Microbiology and Immunology
Defining molecular machinery and cargo sorting along Golgi transport pathways Professor Paul Gleeson Biochemistry and Molecular Biology
Delineating how CD4 T cells ‘help’ establishing effective killer T cell responses Associate Professor Sammy Bedoui Microbiology and Immunology
Dendritic cell maturation following different microbial stimulation Professor William (Bill) Heath Microbiology and Immunology
Design, development and testing of HIV vaccines Professor Damian Purcell Microbiology and Immunology
Designing better drugs Dr David Ascher Biochemistry and Molecular Biology
Developing new therapies for Systemic Lupus Erythematosus Professor Fabienne Mackay Microbiology and Immunology
Development of a self-adjuvanting vaccine for enterotoxigenic Escherichia coli (ETEC) Professor David Jackson Microbiology and Immunology
Development of antimalarial drugs Professor Leann Tilley Biochemistry and Molecular Biology
Development of new types of antimicrobial agents Professor Roy Robins-Browne Microbiology and Immunology
Discovering and characterizing new genes involved in innate immunity, tissue injury and fibrosis Professor Christine Wells Anatomy and Neuroscience
Drug target identification in the malaria parasite Professor Malcolm McConville Biochemistry and Molecular Biology
Elucidating the beneficial and harmful elements of the BAFF/APRIL system in multiple sclerosis Professor Fabienne Mackay | Dr Beatriz Garcillan Microbiology and Immunology
Enterococcus faecium Professor Ben Howden Microbiology and Immunology
Evolution and spread of drug resistance among bacterial pathogens Dr Kathryn Holt Biochemistry and Molecular Biology
Fast foods: Harmful effects of food products on the intestine and liver – AGEs and RAGEs Dr Leni Rivera Anatomy and Neuroscience
Function of MARCH ubiquitin ligases Professor Jose Villadangos Microbiology and Immunology
Furness laboratory: Digestive physiology and nutrition Professor John Furness
Anatomy and Neuroscience
Gametocytogenesis - the sexy side of malaria Professor Leann Tilley Biochemistry and Molecular Biology
Gebhardt laboratory: Adaptive immune responses to virus infections Associate Professor Thomas Gebhardt
Microbiology and Immunology
Gene regulation in Plasmodium falciparum Dr Stuart Ralph Biochemistry and Molecular Biology
Gleeson laboratory: Membrane trafficking and protein sorting in health and disease and development of new therapeutics Professor Paul Gleeson
Biochemistry and Molecular Biology
Global health: Typhoid, dysentery and tuberculosis Dr Kathryn Holt Biochemistry and Molecular Biology
Glycobiology of bacterial-host interactions Dr Nichollas Scott Microbiology and Immunology
Godfrey laboratory: The development and function of unconventional T cells Professor Dale Godfrey
Microbiology and Immunology
Going places: Intracellular trafficking for effective immunity Dr Justine Mintern Biochemistry and Molecular Biology
Gooley laboratory: Structural biology of disease Associate Professor Paul Gooley
Biochemistry and Molecular Biology
Hargreaves laboratory: Exercise physiology Professor Mark Hargreaves
Physiology
Harnessing dendritic cells for vaccine development Professor Jose Villadangos Microbiology and Immunology
Harrap laboratory: Genetic physiology Professor Stephen Harrap
Physiology
Hartland laboratory: Molecular basis of host-pathogen interactions Professor Elizabeth Hartland
Microbiology and Immunology
Heat Shock Protein therapy for muscle wasting Professor Gordon Lynch Physiology
Heath laboratory: CD8 T lymphocytes, dendritic cells, self tolerance and immunity Professor William (Bill) Heath
Microbiology and Immunology
Holt laboratory: Pathogen genomics and bioinformatics Dr Kathryn Holt
Biochemistry and Molecular Biology
Hospital bugs – Klebsiella and Acinetobacter Dr Kathryn Holt Biochemistry and Molecular Biology
How is the immunological T cell memory generated? Associate Professor Katherine Kedzierska Microbiology and Immunology
How MR1 molecules present a novel family of antigens to MAIT cells Dr Hamish McWilliam | Professor Jose Villadangos Microbiology and Immunology
Howden laboratory: Molecular epidemiology, genomics and pathogenesis of antimicrobial resistant bacteria Professor Ben Howden
Microbiology and Immunology
Identification of novel metabolic pathways in Leishmania parasites Professor Malcolm McConville Biochemistry and Molecular Biology
Identifying key metabolic pathways required for Toxoplasma gondii infection Professor Malcolm McConville Biochemistry and Molecular Biology
Identifying the mechanisms of immune cell development in peripheral tissues Dr Laura Mackay Microbiology and Immunology
Imaging effector and memory T cell responses in the skin following Herpes Simplex Virus-1 infection Professor William (Bill) Heath Microbiology and Immunology
Imaging the priming of CD8 Killer T cell responses to Herpes Simplex Virus-1 skin infection Professor William (Bill) Heath Microbiology and Immunology
Immune responses in Legionnaire’s disease Professor Elizabeth Hartland Microbiology and Immunology
Immuno-paralysis following severe infections or trauma Professor Jose Villadangos Microbiology and Immunology
Immunopharmacology Professor Alastair Stewart
Pharmacology and Therapeutics
Improved vaccines by targeting to dendritic cells Professor William (Bill) Heath Microbiology and Immunology
Improving vaccines: Mechanisms of vaccine biology Dr Justine Mintern Biochemistry and Molecular Biology
Infection & Immunity
Influenza A virus PB1-F2 Protein: a putative virulence factor and initiator of inflammation Dr Julie McAuley Microbiology and Immunology
Influenza–specific ADCC: Role in a universal flu vaccine? Professor Stephen Kent Microbiology and Immunology
Innate T cell recognition and development Dr Daniel Pellicci Microbiology and Immunology
Innovative approaches to prepare synthetic, partially synthetic and natural product-based vaccines Professor David Jackson Microbiology and Immunology
Intraepithelial T cells in anti-viral immunity Professor Francis (Frank) Carbone Microbiology and Immunology
Intravital imaging of T cell responses in the brain during cerebral malaria infection Professor William (Bill) Heath Microbiology and Immunology
Investigation of HSV latency and reactivation Professor Francis (Frank) Carbone Microbiology and Immunology
Isolation and Characterization of Major Venom Proteins From Scyphozoan Jellyfish Associate Professor Christine Wright Pharmacology and Therapeutics
Jackson laboratory: Synthetic vaccine design Professor David Jackson
Microbiology and Immunology
Joining the immunotherapy revolution: Adoptive cell therapy against cancer Professor Jose Villadangos Microbiology and Immunology
Kedzierska laboratory: Immunity to pandemic and newly emerged influenza viruses Associate Professor Katherine Kedzierska
Microbiology and Immunology
Kent laboratory: HIV vaccines; immune responses to HIV-1; immunotherapy Professor Stephen Kent
Microbiology and Immunology
Klebsiella pneumoniae Professor Dick Strugnell Microbiology and Immunology
Koopman laboratory: Clinical nutrition and muscle metabolism Dr René Koopman
Physiology
Lawson laboratory: Neurodegenerative disease caused by prions Associate Professor Vicki Lawson
Pathology
Lew laboratory: Theoretical and empirical pharmacology Dr Michael Lew
Pharmacology and Therapeutics
Lipidome profiling of inflammatory biomarkers for beta cell autoimmunity in type 1 diabetes Professor Gavin E. Reid Biochemistry and Molecular Biology
Lipopeptide-based adjuvanting systems Professor David Jackson Microbiology and Immunology
Lung disease Professor Gary Anderson
Pharmacology and Therapeutics
Lung Health Research Centre Pharmacology and Therapeutics
Lymphoid stromal cell responses to infection Associate Professor Scott Mueller Microbiology and Immunology
Mackay (F) laboratory: B lymphocytes, BAFF, autoimmunity and cancer Professor Fabienne Mackay
Microbiology and Immunology
Mackay (L) laboratory: Tissue-resident memory T cells; lymphocyte differentiation; peripheral immunity Dr Laura Mackay
Microbiology and Immunology
Mackenzie laboratory: Intracellular virus replication and innate immunity Associate Professor Jason Mackenzie
Microbiology and Immunology
Malaria and Tissue Resident Memory T cells (TRM) in the liver Professor William (Bill) Heath Microbiology and Immunology
McCluskey laboratory: Role of MAIT cells in health and disease Professor James McCluskey
Microbiology and Immunology
McConville laboratory: Molecular microbiology Professor Malcolm McConville
Biochemistry and Molecular Biology
Mechanisms underlying early generation of human T cell memory Associate Professor Katherine Kedzierska Microbiology and Immunology
Memory T cell responses in the lung during virus infection Dr Linda Wakim Microbiology and Immunology
Mintern laboratory: Vaccine biology Dr Justine Mintern
Biochemistry and Molecular Biology
Molecular immunology and autoimmunity Professor Paul Gleeson Biochemistry and Molecular Biology
Mucosal immune responses during bacterial diarrhoea Dr Catherine Kennedy Microbiology and Immunology
Mueller laboratory: Adaptive immune responses to infection, lymphoid stromal cells, and imaging the immune system Associate Professor Scott Mueller
Microbiology and Immunology
Munsie laboratory: Ethical, legal and social implications of stem cell research Associate Professor Megan Munsie
Anatomy and Neuroscience
Mycobacterium ulcerans Professor TIm Stinear Microbiology and Immunology
Nanoparticle HIV vaccines Professor Stephen Kent Microbiology and Immunology
Nanoparticle Modulation of Mast Cell Function Dr Graham Mackay
Pharmacology and Therapeutics
Nervous regulation of T cell migration and anti-viral Immunity Associate Professor Scott Mueller Microbiology and Immunology
Newton laboratory: Virulence strategies of intracellular bacterial pathogens Dr Hayley Newton
Microbiology and Immunology
NK cell receptor biology Professor Andrew Brooks Microbiology and Immunology
NKT cells, MAIT cells and HIV Professor Stephen Kent Microbiology and Immunology
Non-classical MHC and Class 1-like molecules Professor Andrew Brooks Microbiology and Immunology
Norovirus replication and innate immunity Associate Professor Jason Mackenzie Microbiology and Immunology
Novel drugs and receptors for targeting digestive function Dr Leni Rivera Anatomy and Neuroscience
Novel Mast Cell-Derived Mediators Dr Graham Mackay Pharmacology and Therapeutics
Nutrition: How micronutrients modify digestive function Dr Brid Callaghan Anatomy and Neuroscience
Passive antibody immunity for use in combination microbicides Professor Damian Purcell Microbiology and Immunology
Pathogenesis of chronic lung disease Dr Michelle Hansen
Pharmacology and Therapeutics
Pathogenic bacteria that target mitochondria Dr Diana Stojanovski Biochemistry and Molecular Biology
Priming of T cell responses to viral infection Associate Professor Scott Mueller Microbiology and Immunology
Protein engineering Dr David Ascher Biochemistry and Molecular Biology
Protein trafficking and cellular architecture Professor Leann Tilley Biochemistry and Molecular Biology
Purcell laboratory: Viral RNA elements, regulation of HIV replication, HIV antibody vaccine Professor Damian Purcell
Microbiology and Immunology
Ralph laboratory: Drug targets and gene regulation in Plasmodium falciparum Dr Stuart Ralph
Biochemistry and Molecular Biology
Reading laboratory: Innate immune detection and response to respiratory virus infections Associate Professor Patrick Reading
Microbiology and Immunology
Regulation of Mast Cell Activation Dr Graham Mackay Pharmacology and Therapeutics
Regulation of telomerase activity in B cells Dr Asolina Braun Microbiology and Immunology
Respiratory microbiome in infants and children Dr Kathryn Holt Biochemistry and Molecular Biology
Restoring immunocompetency in Chronic Lymphocytic Leukemia Professor Fabienne Mackay Microbiology and Immunology
RNA mediated control of HIV-1 gene expression Professor Damian Purcell Microbiology and Immunology
Robins-Browne laboratory: Medical bacteriology, pathogenesis, bacterial genetics, therapeutics Professor Roy Robins-Browne
Microbiology and Immunology
Role of cellular lipids during Flavivirus replication Associate Professor Jason Mackenzie Microbiology and Immunology
Role of innate signals in inducing protective T cell immunity Associate Professor Sammy Bedoui Microbiology and Immunology
Rotavirus induction and evasion of innate immunity Associate Professor Barbara Coulson Microbiology and Immunology
Rotavirus modulation of type 1 diabetes development Associate Professor Barbara Coulson Microbiology and Immunology
Rotavirus-cell binding and entry Associate Professor Barbara Coulson Microbiology and Immunology
Salmonella Typhimurium Professor Dick Strugnell Microbiology and Immunology
Self-tolerance: Interactions between thymic stroma and dendritic cells Professor William (Bill) Heath Microbiology and Immunology
Simmons laboratory: Dengue; pathogenesis, epidemiology, therapeutics, entomology Professor Cam Simmons
Microbiology and Immunology
Soluble barriers to influenza virus infection Associate Professor Patrick Reading Microbiology and Immunology
Spinal cord injury: Failure of bowel control Dr Brid Callaghan Anatomy and Neuroscience
Staphylococcus aureus & Enterococcus faecium Professor Tim Stinear Microbiology and Immunology
Staphylococcus aureus and Staphylococcus epidermidis Professor Ben Howden Microbiology and Immunology
Stinear laboratory: Bacterial pathogenomics Professor Tim Stinear
Microbiology and Immunology
Strugnell laboratory: Bacterial pathogenesis and host responses Professor Dick Strugnell
Microbiology and Immunology
T cell responses in the brain during experimental cerebral malaria infection Associate Professor Scott Mueller Microbiology and Immunology
T cells in peripheral immunity Professor Francis (Frank) Carbone Microbiology and Immunology
Tackling drug resistance Dr David Ascher Biochemistry and Molecular Biology
The Cardiovascular Pharmacology of Snake Venoms From Papua New Guinea and Australia Associate Professor Christine Wright Pharmacology and Therapeutics
The innate immune system in the respiratory tract Professor David Jackson Microbiology and Immunology
The mechanisms of viral escape in murine and human influenza infection Associate Professor Katherine Kedzierska Microbiology and Immunology
The molecular basis of the propagation of molecular strain types of prions Associate Professor Vicki Lawson Pathology
The role of CD4+ T cells in viral infections Professor Andrew Brooks Microbiology and Immunology
The Role of CXCR7 in Tissue Fibrosis Dr Asolina Braun Microbiology and Immunology
The role of glucose metabolism and O-GlcNAc glycosylation in the regulation of immunity Dr Nishma Gupta | Professor Jose Villadangos Microbiology and Immunology
The role of glycosaminoglycan in the propagation of prions Associate Professor Vicki Lawson Pathology
The role of innate immune cells in protection and pathology during influenza virus infection Associate Professor Patrick Reading Microbiology and Immunology
The role of resident memory T cells in barrier immunity and autoimmune disease Dr Laura Mackay Microbiology and Immunology
The role of the rabies P protein in host cell evasion and viral replication Associate Professor Paul Gooley Biochemistry and Molecular Biology
The Treatment of Papuan Taipan Envenoming in Papua New Guinea Dr David Williams Pharmacology and Therapeutics
Tilley laboratory: Measuring and modelling malaria parasites to develop new antimalarials Professor Leann Tilley
Biochemistry and Molecular Biology
Tissue-resident memory T cells in the skin Associate Professor Scott Mueller Microbiology and Immunology
Tracking phenotypically and functionally distinct T cell subsets via T cell repertoire diversity Associate Professor Katherine Kedzierska Microbiology and Immunology
Translocated Dot/Icm effectors of Legionella Dr Shivani Pasricha Microbiology and Immunology
Translocated Type III secretion system effectors of bacterial pathogens Dr Jaclyn Pearson Microbiology and Immunology
Uncovering the interplay between innate immunity and the blood brain barrier in disorders of the CNS Professor Christine Wells Anatomy and Neuroscience
Understanding the interaction between microbiota and T cell immunity Associate Professor Sammy Bedoui Microbiology and Immunology
Understanding the molecular consequences of mutations Dr David Ascher Biochemistry and Molecular Biology
Understanding the regulation of tissue-resident memory T cell development Dr Laura Mackay Microbiology and Immunology
Understanding the role of glycine in the control of skeletal muscle mass during sepsis Dr René Koopman Physiology
Understanding ‘universal’ influenza-specific CD8+ T cell responses Associate Professor Katherine Kedzierska Microbiology and Immunology
Using biochemical approaches to investigating the trafficking and mechanism of action of the antiviral molecule, IFITM3 Dr Linda Wakim Microbiology and Immunology
Vaccination against liver-stage Plasmodium for malaria prevention Professor William (Bill) Heath Microbiology and Immunology
van Driel laboratory: Immune responses to pathogens Professor Ian van Driel
Biochemistry and Molecular Biology
Villadangos laboratory: Antigen presenting cells & molecules that initiate T cell immunity against pathogens and cancer Professor Jose Villadangos
Microbiology and Immunology
Viral interactions with the innate immune system Associate Professor Patrick Reading Microbiology and Immunology
Visualization and formation West Nile Virus replication complexes Associate Professor Jason Mackenzie Microbiology and Immunology
Wakim laboratory: Antiviral molecules, mucosal immunology, influenza virus, tissue resident memory T cells Dr Linda Wakim
Microbiology and Immunology
Wells laboratory: Stem cell systems Professor Christine Wells
Anatomy and Neuroscience
West Nile Virus replication and cellular stress responses Associate Professor Jason Mackenzie Microbiology and Immunology
Wolbachia to stop dengue transmission in Vietnam and Indonesia Professor Cameron Simmons Microbiology and Immunology