Sex, adiposity and cardiac vulnerability

Project Details

Is a ‘fat heart’ an especially vulnerable heart – a role for locally synthesized steroids?

Important differences exist between women and men with regard to cardiovascular disease. This is likely related to sex steroid (estrogen and testosterone) actions on the heart. However, recent controversies about the use of sex steroid therapies in men and women highlight a lack of understanding of the underlying mechanisms by which sex and sex steroids influence the heart. We have recently shown in humans that both the myocardium and cardiac adipose express the enzyme aromatase – showing that estrogen synthesis can actually occur within the myocardium. As cardiac adipose accumulates in aging/obesity, the influence of this locally synthesised estrogen likely increases. Cardiac adiposity has emerged as an important causative risk factor in cardiac arrhythmia vulnerability by currently unknown mechanisms. Our data indicate a potential role for adipose derived estrogen. This project will use molecular and tissue recording studies of human and rodent tissues to determine how estrogens synthesised within cardiac adipose contribute to the development of cardiac arrhythmias.

Collaborators

Bell Research Group at La Trobe University

Research Opportunities

This research project is available to PhD, Masters by Research, Master of Biomedical Science students to join as part of their thesis.
Please contact the Research Group Leader to discuss your options.

Research Group

Delbridge laboratory: Cardiac phenomics


School Research Themes

Cardio-Respiratory, Molecular Mechanisms of Disease, Systems Biology, Cell Signalling



Key Contact

For further information about this research, please contact the research group leader.

Department / Centre

Physiology

MDHS Research library
Explore by researcher, school, project or topic.