Stem Cells and Disease Modelling
By creating a replica of the affected tissue in the lab from stem cells, researchers in this theme are able to gain a greater understanding of how various diseases manifest and where there maybe opportunities to intervene to prevent progression of disease or instigate tissue repair.
![]() | Neuroregeneration - Professor Alice PébayResearch focus: using stem cells for modelling and correcting retinal degeneration. |
![]() | Visual neuroscience - Professor Erica FletcherResearch focus: understanding photoreceptor death during retinal degradation and ways to replace these photoreceptors. The lab is also interested in the role of glia in retinal disease. |
![]() | Regulation of the immune system in the brain and eye - Dr Matt RutarResearch focus: exploring the immunological vistas of the central nervous system, in particular using the eye as a system for driving insights into the innate immune system and macrophage biology in health and disease. |
![]() | Mechanopharmacology - Professor Alastair StewartResearch focus: investigating inflammation and fibrosis mechanisms using novel bio-assays for drug discovery and characterisation. |
![]() | Tumour Heterogeneity in Metastatic Cancer - Professor Fred HollandeResearch focus: understanding the mechanisms that underlie the genetic and non-genetic heterogeneity within individual tumours. |
![]() | Gastrointestinal Cancer - Professor Elizabeth VincanResearch focus: investigating novel ways to block cancer growth with a focus on the gastrointestinal tract, including the interaction of a cell-cell communication pathway called Wnt. The lab is also establishing an organoid platform for studying infectious disease. |
![]() | Multiple Sclerosis - Professor Trevor KilpatrickResearch focus: examining oligodendrocyte biology and neuroinflammation as well as regenerative medicine and its application to MS. |
![]() | Stem Cells and Neural Development - Professor Clare ParishResearch focus: repairing the injured brain and understanding neural development. |
![]() | Neurogenesis and Neural Transplantation - A/ Professor Lachlan ThompsonResearch focus: exploring how stem cells can repair the damaged brain. |
![]() | Ion Channels and Human Diseases - Professor Steve PetrouResearch focus: understanding the pathology of ion channel disorders, in particular epilepsy, using in vitro and in vivo models to reveal opportunities for developing novel therapies. |
![]() | Motor Neuron Disease - A/ Professor Bradley TurnerResearch focus: employing a combination of cell and molecular biology to unravel MND pathogenesis in patient-derived samples, cell culture and animal models. |
![]() | Motor Neurone Disease Drug Screening - Dr Christopher ByeResearch focus: rapidly exploring potential treatments for Motor Neurone Disease. |
![]() | Cardiac Regeneration - A/ Professor Enzo PorrelloResearch focus: understanding the molecular and cellular mechanisms that govern heart development and regeneration. |
![]() | Cardiac Regeneration - Dr David ElliottResearch focus: using pluripotent stem cells to study human heart development and disease. |
![]() | Kidney Development, Disease and Regeneration - Professor Melissa LittleResearch focus: exploring the genes required for normal kidney development and what happens as a result of genetic or environmental damage during development. |
![]() | Cellular Reprogramming - Dr Raymond WongResearch focus: better understanding and developing treatment for eye diseases using cell reprogramming and stem cell technologies. |
![]() | ACRF Cancer Biology and Stem Cells: Professor Jane VisvaderResearch focus: molecular regulators of normal breast development and cancer, with a particular interest in breast stem cells and the breast epithelial cell hierarchy. |
![]() | Vascular Biology - A/ Professor Geraldine MitchellResearch focus: improving methods of vascularization (blood vessel growth) for tissue engineering and wound healing. |
![]() | Clinical haematology - Dr Ashley NgResearch focus: exploring how blood cells are produced from stem cells, and how this process is corrupted in blood diseases. |
![]() | Translational Haematology - Professor Mark DawsonResearch focus: understanding the role of epigenetic regulators in normal and malignant haemopoiesis. |
![]() | Brain Cancer Molecular Biology - Dr Theo MantamadiotisResearch focus: investigations into transcriptional and signalling networks involved in neuronal development, neural stem cells and brain tumour cells. |