Oxidative stress and neural injury
The major focus of our laboratory are the mechanisms that underpin the progression of neural injury. The causes of neural injury are multifactorial so our laboratory's research is focused on the role that oxidative stress and reactive oxygen species (ROS) play in the predisposition and/or progression of neural injury. Rather than serving solely as harmful by-products of aerobic metabolism, it has become apparent that ROS have a much broader role in the regulation and co-ordination of cellular homeostasis. ROS are used to fine-tune cellular signaling and play an important role in the transduction of message along specific signal transduction pathways. In the event of oxidative stress, which is associated with varied human diseases including neurological disorders, the persistent inactivation of signal transduction pathways by ROS may lead to reduced or ablated, sustained or elevated cellular signaling and predispose or otherwise contribute to disease pathology. In understanding how signal transduction systems are regulated by oxidative stress and ROS we can gain a better understanding how new generation therapeutics can target these pathways in the hope to reduce and or prevent neuronal pathology.
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