Prognostic biomarker and therapeutic target discovery in stroke
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Stroke causes substantial morbidity and mortality globally, and presents significant challenges to clinicians who treat these emergency cases. Aneurysmal subarachnoid haemorrhage (aSAH) causes 27% of years of life lost due to stroke in people under 65 years of age. A key clinical challenge in aSAH is understanding patient prognosis once they are stabilised and in intensive care. About half of patients with aSAH experience severe complications that cause disablement and death.
A major cause of post-aSAH complications is delayed cerebral ischaemia, where the brain is starved of oxygen. What causes these ischaemic events is not well understood, and it is currently impossible to predict which patients are at most risk of developing the condition.
In this project, a collaboration with Associate Professor James Ziogas and Dr Alex Adamides, we are using proteomic analyses on cerebrospinal fluid from patients with aneurysmal subarachnoid haemorrhage, asking what is different in those patients that experience vasospasm. Having discovered potential prognostic biomarkers and therapeutic targets, we are working to translate the findings. Outcomes may include a better understanding of the mechanisms of vasospasm associated with neurotrauma, and opportunities for therapeutic interception of these complications.
This research project is available to Masters and PhD students to join as part of their thesis.
Please contact the Research Group Leader to discuss.
Associate Professor J Ziogas, Lab Head
Dr Alex Adamides, Neurosurgeon
Associate Professor Peter Crack
Dr Tom Hennesey
- Mangum JE, Kon JC, Hubbard MJ. Proteomic analysis of dental tissue microsamples. Methods Mol Biol 2017; 1537: 461-479.
- Mangum JE, Veith PD, Reynolds EC, Hubbard MJ. Towards second-generation proteome analysis of murine enamel-forming cells. Eur J Oral Sci 2006; 114(Suppl 1): 259-265.
- Mangum JE, Farlie PG, Hubbard MJ. Proteomic profiling of facial development in chick embryos. Proteomics 2005; 5(10): 2542-2550.
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