Shane Liddelow co-authors Nature Medicine paper
Block of A1 astrocyte conversion by microglia is neuroprotective in models of Parkinson’s disease.
Congratulations to Shane Liddelow, of the Department of Pharmacology and Therapeutics, who co-authored a paper published in the June edition of Nature Medicine.
The paper explores how activation of microglia by classical inflammatory mediators can convert astrocytes into a neurotoxic A1 phenotype in a variety of neurological diseases.
Development of agents that could inhibit the formation of A1 reactive astrocytes could be used to treat these diseases – for which there are no disease-modifying therapies.