Parker laboratory: Metabolic Proteomics & Signal Transduction

Research Overview

View Dr Parker's latest PubMed publications listing here

The Metabolic Proteomics and Signal Transduction Group is focused on understanding how signal transduction regulates metabolism with the goal of identifying new therapeutic targets to treat disease. We are particularly interested in studying dynamic changes in proteins and their post-translational modifications, and understanding how these are regulated by genetic variants and metabolic insults to ultimately shape cellular physiology. We primarily focus on metabolic tissues such as liver and adipose with a strong emphasis on muscle.

There are numerous diseases that involve defective muscle metabolism. These include sarcopenia or cachexia that are one of the most debilitating consequences of ageing and cancer, cardiomyopathies that form a significant fraction of cardiovascular disease, and also type 2 diabetes characterised by a major defect in the ability of muscle to take up glucose in response to insulin. It is crucial to develop better approaches to investigate the many functions of muscle, including how it develops, how it is regenerated, how it is effected by physical activity, how defects in muscle function contribute to disease, and the identification and development of novel therapeutics targeted to muscle.

We use a multi-disciplinary approach to answer these questions incorporating proteomics, cell biology, molecular biology, and physiology, and have a vast collaborative network of computational biologists, geneticists, tissue engineers, stem cell biologists and experts in molecular therapies.

Staff

Dr Benjamin Parker, Research Fellow and Head of Laboratory

Collaborators

A/Prof Paul Gregorevic, University of Melbourne

Prof Matt Watt, University of Melbourne

Prof Gordon Lynch, University of Melbourne

Prof Stephen Wilton, Murdoch University

Prof David James, University of Sydney

Prof Jake Lusis, UCLA

Prof Karen Reue, UCLA

Dr Marcus Seldin, UCLA

Dr Anna Calkin, Baker IDI

Dr Brian Drew, Baker IDI

Prof Erik Richter, University of Copenhagen

Prof Jurgen Wojtaszewski, University of Copenhagen

Dr Thomas Jensen, University of Copenhagen

Dr Lykke Sylow, University of Copenhagen

Dr James Hudson, QIMR

Dr Richard Mills, QIMR

Dr Morten Thaysen-Andersen, Macquarie University

Prof Richard Payne, University of Sydney

Prof Stephen Simpson, University of Sydney

Prof Joel Mackay, University of Sydney

A/Prof. Carsten Schmitz-Peiffer, Garvan Institute

Dr Hayley O’Neill, Bond University

A/Prof Jon Oakhill, SVI

Dr Joseph Brozinick, Eli Lilly

Dr Christian Pehmoller, Pfizer

Funding

2017-2019 NHMRC Project Grant. Skeletal muscle signal transduction related to exercise, metabolic disease and human health (APP1122376)

2019-2021 NHMRC Project Grant. Developing a novel class of therapeutics for muscle wasting and frailty (APP1156562)