Jeff Liddell

Many neurodegenerative diseases share common pathology including the well-established features of oxidative stress and inflammation. Less recognised is aberrant biometal regulation, which involves the loss, gain or mislocalisation of essential metals such as iron, copper and zinc. My therapeutic strategy aims to restore metal homeostasis and augment endogenous protective pathways to prevent neuronal failure. I use human tissue, animal models of neurodegeneration and cultured brain cells to investigate how astrocytes and microglia interact to modulate neuronal function and survival in the central nervous system. Our research has led to translation of the drug copper-ATSM into current clinical trials in Australian motor neuron disease and Parkinson’s disease patients.
Dr Jeff Liddell is a postdoc in the research group of A/Prof Peter Crouch in the Department of Pharmacology and Therapeutics, University of Melbourne. He completed his PhD in 2011 at Monash University before undertaking postdoctoral studies with A/Prof Anthony White in the Department of Pathology, University of Melbourne. Recently completing an NHMRC Peter Doherty fellowship, he joined A/Prof Peter Crouch in 2017.

  • Contact Details
    Department:Pharmacology and Therapeutics
    Phone:03 9035 6041
  • Current Research Focus

    Biology of neurological diseases

    Field of ResearchDescription
    110902Cellular Nervous System
    110903Central Nervous System
  • Key Skills
    • Cell biology
    • Cell culture
    • Neuroscience