By creating a replica of the affected tissue in the lab from stem cells, researchers in this theme are able to gain a greater understanding of how various diseases manifest and where there maybe opportunities to intervene to prevent progression of disease or instigate tissue repair.
Research focus: using stem cells for modelling and correcting retinal degeneration.
Research focus: understanding photoreceptor death during retinal degradation and ways to replace these photoreceptors. The lab is also interested in the role of glia in retinal disease.
Research focus: exploring the immunological vistas of the central nervous system, in particular using the eye as a system for driving insights into the innate immune system and macrophage biology in health and disease.
Research focus: investigating inflammation and fibrosis mechanisms using novel bio-assays for drug discovery and characterisation.
Research focus: understanding the mechanisms that underlie the genetic and non-genetic heterogeneity within individual tumours.
Research focus: investigating novel ways to block cancer growth with a focus on the gastrointestinal tract, including the interaction of a cell-cell communication pathway called Wnt. The lab is also establishing an organoid platform for studying infectious disease.
Research focus: examining oligodendrocyte biology and neuroinflammation as well as regenerative medicine and its application to MS.
Research focus: repairing the injured brain and understanding neural development.
Research focus: exploring how stem cells can repair the damaged brain.
Research focus: understanding the pathology of ion channel disorders, in particular epilepsy, using in vitro and in vivo models to reveal opportunities for developing novel therapies.
Research focus: employing a combination of cell and molecular biology to unravel MND pathogenesis in patient-derived samples, cell culture and animal models.
Research focus: rapidly exploring potential treatments for Motor Neurone Disease.
Research focus: understanding the molecular and cellular mechanisms that govern heart development and regeneration.
Research focus: using pluripotent stem cells to study human heart development and disease.
Research focus: exploring the genes required for normal kidney development and what happens as a result of genetic or environmental damage during development.
Research focus: better understanding and developing treatment for eye diseases using cell reprogramming and stem cell technologies.
Research focus: molecular regulators of normal breast development and cancer, with a particular interest in breast stem cells and the breast epithelial cell hierarchy.
Research focus: improving methods of vascularization (blood vessel growth) for tissue engineering and wound healing.
Research focus: exploring how blood cells are produced from stem cells, and how this process is corrupted in blood diseases.
Research focus: understanding the role of epigenetic regulators in normal and malignant haemopoiesis.
Research focus: investigations into transcriptional and signalling networks involved in neuronal development, neural stem cells and brain tumour cells.