Lynch laboratory: Basic and clinical myology
We are interested in the cellular and molecular mechanisms underlying skeletal muscle development and regeneration, muscle adaptation and plasticity, as well as the muscle wasting and weakness associated with ageing (sarcopenia), cancer, disuse and muscle diseases and conditions, including the muscular dystrophies and critical illness myopathy.
We are currently investigating skeletal muscle development and regeneration following injury and repair from single muscle stem cells, through to functional muscle fibres and whole muscles. We have a specific focus on stem cell self-renewal and how cellular metabolism may regulate the commitment of muscle stem cells to the myogenic lineage. We hope that a better understanding of these mechanisms will translate to improvements in autologous stem cell transplant therapies applicable to many muscle diseases and conditions.
Our studies on muscle adaptation and plasticity, wasting and weakness encompass investigations of the molecular pathways regulating muscle size and function with a translational approach from cell culture experiments complemented by different animal models as unique platforms for studying muscle wasting, adaptation and plasticity.
Our ultimate goal is to translate our fundamental biological discoveries to human patients through our extensive international collaborative network of geriatricians, critical care physicians, surgeons, neurologists, rheumatologists, anaesthetists, oncologists, endocrinologists, orthodontists, as well as biomedical and tissue engineers.
Dr James Ryall, Post Doctoral Fellow
Dr Kristy Swiderski, Post Doctoral Fellow
Dr Kate Murphy, Post Doctoral Fellow
Fiona Colarossi,Lab Manager
Megan Hepworth, Research Assistant
Jennifer Trieu, Research Assistant
Timur Naim , Research Assistant
Victoria Chhen, Research Assistant
- Koopman R, Caldow MK, Ham DJ, Lynch GS. Glycine metabolism in skeletal muscle: implications for metabolic homeostasis. 2017 Curr Opin Clin Nutr Metab Care 2017; Apr 3.
- Swiderski K, Thakur SS, Naim T, Trieu J, Chee A, Stapleton DI, Koopman R, Lynch GS. Muscle-specific deletion of SOCS3 increases the early inflammatory response but does not affect regeneration after myotoxic injury. Skeletal Muscle 2016: 6: 36.
- Kennedy TL, Swiderski K, Murphy KT, Gehrig SM, Curl CL, Chandramouli C, Febbraio MA, Delbridge LM, Koopman R, Lynch GS. BGP-15 improves aspects of the dystrophic pathology in mdx and dko mice with differing efficacies in heart and skeletal muscle. American Journal of Pathology 2016 Dec; 186(12): 3246-3260.
- Winbanks CE, Murphy KT, Bernardo BC, Qian H, Liu Y, Sepulveda PV, Beyer C, Hagg A, Thomson RE, Chen JL, Walton KL, Loveland KL, McMullen-JR, Rodgers BD, Harrison CA, LYNCH GS, Gregorevic P. Science Translational Medicine 2016 Jul 20; 8(348): 348ra98.
- Ham DJ, Caldow MK, Chhen V Chee, A Wang X, Proud CG, Lynch GS, Koopman R. Glycine restores the anabolic response to leucine in a mouse model of acute inflammation. American Journal of Physiology - Endocrinology and Metabolism 2016 Jun 1; 310(11): E970-81.
- Hagg A, Colgan TD, Thomson RE, Qian H, Lynch GS,Gregorevic P. Using AAV vectors expressing the β2-adrenoceptor or associated Gα proteins to modulate skeletal muscle mass and muscle fibre size. Scientific Reports 2016 Mar 14; 6: 23042.
- Johnston AJ, Murphy KT, Jenkinson L, Laine D, Emmrich K, Faou P, Weston R, Jayatilleke KM, Schloegel J, Talbo G. Schneider P, Tanzer M, Foley M, Scott AM, Gregorevic P, Liu SY,Lynch GS, Silke J, Hoogenraad NJ. Targeting of Fn14 Prevents Cancer-Induced Cachexia and Prolongs Survival. Cell 2015 Sep 10; 162(6): 1365-78.
See PUB MED for a full list of Gordon's publications.
- Understanding the cellular cues that direct muscle stem cell specification
- Heat Shock Protein therapy for muscle wasting
- Therapeutic potential of skeletal muscle plasticity and slow muscle programming for muscular dystrophy
- A simple method to improve stem cell transplant therapy
- Novel interventions to treat cardiac cachexia in cancer and chemotherapy
Faculty Research Themes
School Research Themes
For further information about this research, please contact Professor Gordon Lynch