Gooley laboratory: Structural biology of disease
Research in the Gooley laboratory uses solution structural biology techniques to understand the mechanism of action of proteins. The major structural tool used is solution nuclear magnetic resonance spectroscopy, but we take advantage of other approaches including isothermal titration calorimetry, surface plasmon resonance, X-ray scattering, X-ray crystallography and fluorescence spectroscopy. Research focuses on protein-protein and protein-ligand interactions that are linked to disease with the goal of finding novel ligands or designing new therapies for treatment. Examples of current projects include investigating how G-protein coupled receptors transmit biological signals. This program includes unravelling how the relaxin family of GPCRs work. More recently we have started to study ligand recognition and pathways of ligand binding of the neurotensin and the adreno receptors. Another new area of research is investigating how the proteins produced by the rabies virus evade the interferon-mediated pathway. This program aims to elucidate the interaction of the viral P-protein with the host’s STAT proteins as well as with other viral proteins.
Go to this site to download NESSY.
For applications see Bieri, M. and Gooley, P.R. “Automated NMR relaxation dispersion data analysis using NESSY.” BMC Bioinformatics 2011; 12: 421.
Currently there is no support for NESSY.
Fei Yan, Research assistant
Ashish Sethi, PhD Student, cosupervised with Ross Bathgate (Florey)
Shoni Bruell, PhD Student, cosupervised with Ross Bathgate (Florey)
Samantha Lagaida, PhD Student
Fabian Bumbak, PhD Student, cosupervised with Ross Bathgate and Dan Scott (Florey)
Kelvin Yong, PhD Student, cosupervised with Ross Bathgate and Dan Scott (Florey)
Tasneem Vaid, PhD Student, cosupervised with Dan Scott (Florey)
Fengjie Wu, PhD Student, cosupervised with Dan Scott (Florey)
Alamgir Hossain, PhD Student, cosupervised with Greg Moseley
Jingyu Zhan, PhD Student, cosupervised with Greg Moseley
Estella Newcombe, PhD Student, cosupervised with Danny Hatters
Prof Ross Bathgate
Associate Prof Marie Bogoyevitch
Dr Mike Griffin
Associate Prof Danny Hatters
Dr Akhter Hossain
Dr Margaret Johnson
Dr Greg Moseley
Dr Dan Scott
Prof Spencer Williams
NHMRC Project grant: “Interrogating peptide receptor targets.”
NHMRC Project grant: “Novel approaches to understanding peptide G-protein-coupled receptor activation”
NHMRC Project grant: “Unravelling the binding and activation mechanism of a complex G protein-coupled receptor”.
Click here for the results of a PubMed search of Paul's publications.
Click here for the results of a Google Scholar analysis of Paul's publications.
- How does Relaxin activate its G-protein coupled receptor?
- Characterizing allosteric sites and conformational diversity of G-protein coupled receptors
- The role of the rabies P protein in evading the interferon-mediated pathway
Faculty Research Themes
School Research Themes
For further information about this research, please contact Associate Professor Paul Gooley